Numerical modelling of the growth and remodelling phenomena in biological tissues
Living biological tissues are complex structures that have the capacity of evolving in response to external loads and environmental stimuli. The adequate modelling of soft biological tissue behaviour is a key issue in successfully reproducing biomechanical problems through computational analysis. Th...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/436906 |
| Acceso en línea: | http://hdl.handle.net/10803/436906 https://dx.doi.org/10.5821/dissertation-2117-108955 http://mediaserver.csuc.cat/tdx/documents/98/90/06/98900611291200778847357687614063007514/ |
| Access Level: | acceso abierto |
| Palabra clave: | Àrees temàtiques de la UPC::Enginyeria dels materials 004 620 |
| Sumario: | Living biological tissues are complex structures that have the capacity of evolving in response to external loads and environmental stimuli. The adequate modelling of soft biological tissue behaviour is a key issue in successfully reproducing biomechanical problems through computational analysis. This study presents a general constitutive formulation capable of representing the behaviour of these tissues through finite element simulation. It is based on phenomenological models that, used in combination with the generalized mixing theory, can numerically reproduce a wide range of material behaviours. First, the passive behaviour of tissues is characterized by means of hyperelastic and finite-strain damage models. A new generalized damage model is proposed, providing a flexible and versatile formulation that can reproduce a wide range of tissue behaviour. It can be particularized to any hyperelastic model and requires identifying only two material parameters. Then, the use of these constitutive models with generalized mixing theory in a finite-strain framework is described and tools to account for the anisotropic behaviour of tissues are put forth. The active behaviour of tissues is characterized through constitutive models capable of reproducing the growth and remodelling phenomena. These are built on the hyperelastic and damage formulations described above and, thus, represent the active extension of the passive tissue behaviour. A growth model considering biological availability is used and extended to include directional growth. In addition, a novel constitutive model for homeostatic-driven turnover remodelling is presented and discussed. This model captures the stiffness recovery that occurs in healing tissues, understood as a recovery or reversal of damage in the tissue, which is driven by both mechanical and biochemical stimuli. Finally, the issue of correctly identifying the material parameters for computational modelling is addressed. An inverse method using optimization techniques is developed to facilitate the identification of these parameters. |
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