Preference for guanosine at first codon position in highly expressed Escherichia coli genes. A relationship with translational efficiency
The variation in base composition at the three codon sites in relation to gene expressivity, the latter esti- mated by the Codon Adaptation Index, has been studied in a sample of 1371 Escherichia coli genes. Correlation and regression analyses show that in- creasing expression levels are accompanied...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 1996 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/36772 |
| Acceso en línea: | http://hdl.handle.net/11441/36772 https://doi.org/10.1093/nar/24.13.2525 |
| Access Level: | acceso abierto |
| Palabra clave: | Guanosine Bacterial gene Codon usage Dna base composition Escherichia coli Gene expression Nonhuman Priority journal Regression analysis Rna translation |
| Sumario: | The variation in base composition at the three codon sites in relation to gene expressivity, the latter esti- mated by the Codon Adaptation Index, has been studied in a sample of 1371 Escherichia coli genes. Correlation and regression analyses show that in- creasing expression levels are accompanied by higher frequencies of base G at first, of base A at second and of base C at third codon positions. However, correla- tion between expressivity and base compositional biases at each codon site was only significant and positive at first codon position. The preference for G-starting codons as gene expression level increases is discussed in terms of translational optimization |
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