The impact of nanomaterials on autophagy across health and disease conditions

Autophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) an...

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Detalhes bibliográficos
Autores: Florance, Ida, Cordani, Marco, Pashootan, Parya, Moosavi, Mohammad Amin, Zarrabi, Ali, Chandrasekaran, Natarajan
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/104033
Acesso em linha:https://hdl.handle.net/20.500.14352/104033
Access Level:acceso abierto
Palavra-chave:577.2
Autophagic flux
Autophagy blockade
Environmental toxicity
Nanoparticles
Nanoplastics
Regulated cell death
Biología celular (Biología)
Bioquímica (Biología)
2407 Biología Celular
2403 Bioquímica
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oai_identifier_str oai:docta.ucm.es:20.500.14352/104033
network_acronym_str ES
network_name_str España
repository_id_str
spelling The impact of nanomaterials on autophagy across health and disease conditionsFlorance, IdaCordani, MarcoPashootan, ParyaMoosavi, Mohammad AminZarrabi, AliChandrasekaran, Natarajan577.2Autophagic fluxAutophagy blockadeEnvironmental toxicityNanoparticlesNanoplasticsRegulated cell deathBiología celular (Biología)Bioquímica (Biología)2407 Biología Celular2403 BioquímicaAutophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) and nanoplastics (nPs). This has positioned autophagy modulation at the forefront of nanotechnology-based therapeutic interventions. While NMs can exploit autophagy to enhance therapeutic outcomes, they can also trigger it as a pro-survival response against NP-induced toxicity. Conversely, a heightened autophagy response may also lead to regulated cell death (RCD), in particular autophagic cell death, upon NP exposure. Thus, the relationship between NMs and autophagy exhibits a dual nature with therapeutic and environmental interventions. Recognizing and decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. This review delves into the present-day therapeutic potential of autophagy-modulating NMs, shedding light on their status in clinical trials, intervention of autophagy in the therapeutic applications of NMs, discusses the potency of autophagy for application as early indicator of NM toxicity.SpringerSpringerUniversidad Complutense de Madrid20242024-04-1720242024-04-17journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/104033reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1040332026-06-02T12:44:21Z
dc.title.none.fl_str_mv The impact of nanomaterials on autophagy across health and disease conditions
title The impact of nanomaterials on autophagy across health and disease conditions
spellingShingle The impact of nanomaterials on autophagy across health and disease conditions
Florance, Ida
577.2
Autophagic flux
Autophagy blockade
Environmental toxicity
Nanoparticles
Nanoplastics
Regulated cell death
Biología celular (Biología)
Bioquímica (Biología)
2407 Biología Celular
2403 Bioquímica
title_short The impact of nanomaterials on autophagy across health and disease conditions
title_full The impact of nanomaterials on autophagy across health and disease conditions
title_fullStr The impact of nanomaterials on autophagy across health and disease conditions
title_full_unstemmed The impact of nanomaterials on autophagy across health and disease conditions
title_sort The impact of nanomaterials on autophagy across health and disease conditions
dc.creator.none.fl_str_mv Florance, Ida
Cordani, Marco
Pashootan, Parya
Moosavi, Mohammad Amin
Zarrabi, Ali
Chandrasekaran, Natarajan
author Florance, Ida
author_facet Florance, Ida
Cordani, Marco
Pashootan, Parya
Moosavi, Mohammad Amin
Zarrabi, Ali
Chandrasekaran, Natarajan
author_role author
author2 Cordani, Marco
Pashootan, Parya
Moosavi, Mohammad Amin
Zarrabi, Ali
Chandrasekaran, Natarajan
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Springer
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.2
Autophagic flux
Autophagy blockade
Environmental toxicity
Nanoparticles
Nanoplastics
Regulated cell death
Biología celular (Biología)
Bioquímica (Biología)
2407 Biología Celular
2403 Bioquímica
topic 577.2
Autophagic flux
Autophagy blockade
Environmental toxicity
Nanoparticles
Nanoplastics
Regulated cell death
Biología celular (Biología)
Bioquímica (Biología)
2407 Biología Celular
2403 Bioquímica
description Autophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) and nanoplastics (nPs). This has positioned autophagy modulation at the forefront of nanotechnology-based therapeutic interventions. While NMs can exploit autophagy to enhance therapeutic outcomes, they can also trigger it as a pro-survival response against NP-induced toxicity. Conversely, a heightened autophagy response may also lead to regulated cell death (RCD), in particular autophagic cell death, upon NP exposure. Thus, the relationship between NMs and autophagy exhibits a dual nature with therapeutic and environmental interventions. Recognizing and decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. This review delves into the present-day therapeutic potential of autophagy-modulating NMs, shedding light on their status in clinical trials, intervention of autophagy in the therapeutic applications of NMs, discusses the potency of autophagy for application as early indicator of NM toxicity.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-04-17
2024
2024-04-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/104033
url https://hdl.handle.net/20.500.14352/104033
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869416716359958528
score 15,300724

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