Biohybrid robotics: From the nanoscale to the macroscale

Biohybrid robotics is a field in which biological entities are combined with artificial materials in order to obtain improved performance or features that are difficult to mimic with hand-made materials. Three main level of integration can be envisioned depending on the complexity of the biological...

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Detalles Bibliográficos
Autores: Mestre, Rafael, Patiño, Tania, Sanchez, Samuel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/196622
Acceso en línea:https://hdl.handle.net/2445/196622
Access Level:acceso abierto
Palabra clave:Nanotecnologia
Robòtica
Materials biomèdics
Nanotechnology
Robotics
Biomedical materials
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spelling Biohybrid robotics: From the nanoscale to the macroscaleMestre, RafaelPatiño, TaniaSanchez, SamuelNanotecnologiaRobòticaMaterials biomèdicsNanotechnologyRoboticsBiomedical materialsBiohybrid robotics is a field in which biological entities are combined with artificial materials in order to obtain improved performance or features that are difficult to mimic with hand-made materials. Three main level of integration can be envisioned depending on the complexity of the biological entity, ranging from the nanoscale to the macroscale. At the nanoscale, enzymes that catalyze biocompatible reactions can be used as power sources for self-propelled nanoparticles of different geometries and compositions, obtaining rather interesting active matter systems that acquire importance in the biomedical field as drug delivery systems. At the microscale, single enzymes are substituted by complete cells, such as bacteria or spermatozoa, whose self-propelling capabilities can be used to transport cargo and can also be used as drug delivery systems, for in vitro fertilization practices or for biofilm removal. Finally, at the macroscale, the combinations of millions of cells forming tissues can be used to power biorobotic devices or bioactuators by using muscle cells. Both cardiac and skeletal muscle tissue have been part of remarkable examples of untethered biorobots that can crawl or swim due to the contractions of the tissue and current developments aim at the integration of several types of tissue to obtain more realistic biomimetic devices, which could lead to the next generation of hybrid robotics. Tethered bioactuators, however, result in excellent candidates for tissue models for drug screening purposes or the study of muscle myopathies due to their three-dimensional architecture.2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/196622Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1002/wnan.1703Wiley Interdisciplinary Reviews-Nanomedicine And Nanobiotechnology, 2021, vol. 13, num. 5, p. e1703https://doi.org/10.1002/wnan.1703(c) Wiley periodicals, 2021info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1966222026-05-27T06:46:51Z
dc.title.none.fl_str_mv Biohybrid robotics: From the nanoscale to the macroscale
title Biohybrid robotics: From the nanoscale to the macroscale
spellingShingle Biohybrid robotics: From the nanoscale to the macroscale
Mestre, Rafael
Nanotecnologia
Robòtica
Materials biomèdics
Nanotechnology
Robotics
Biomedical materials
title_short Biohybrid robotics: From the nanoscale to the macroscale
title_full Biohybrid robotics: From the nanoscale to the macroscale
title_fullStr Biohybrid robotics: From the nanoscale to the macroscale
title_full_unstemmed Biohybrid robotics: From the nanoscale to the macroscale
title_sort Biohybrid robotics: From the nanoscale to the macroscale
dc.creator.none.fl_str_mv Mestre, Rafael
Patiño, Tania
Sanchez, Samuel
author Mestre, Rafael
author_facet Mestre, Rafael
Patiño, Tania
Sanchez, Samuel
author_role author
author2 Patiño, Tania
Sanchez, Samuel
author2_role author
author
dc.subject.none.fl_str_mv Nanotecnologia
Robòtica
Materials biomèdics
Nanotechnology
Robotics
Biomedical materials
topic Nanotecnologia
Robòtica
Materials biomèdics
Nanotechnology
Robotics
Biomedical materials
description Biohybrid robotics is a field in which biological entities are combined with artificial materials in order to obtain improved performance or features that are difficult to mimic with hand-made materials. Three main level of integration can be envisioned depending on the complexity of the biological entity, ranging from the nanoscale to the macroscale. At the nanoscale, enzymes that catalyze biocompatible reactions can be used as power sources for self-propelled nanoparticles of different geometries and compositions, obtaining rather interesting active matter systems that acquire importance in the biomedical field as drug delivery systems. At the microscale, single enzymes are substituted by complete cells, such as bacteria or spermatozoa, whose self-propelling capabilities can be used to transport cargo and can also be used as drug delivery systems, for in vitro fertilization practices or for biofilm removal. Finally, at the macroscale, the combinations of millions of cells forming tissues can be used to power biorobotic devices or bioactuators by using muscle cells. Both cardiac and skeletal muscle tissue have been part of remarkable examples of untethered biorobots that can crawl or swim due to the contractions of the tissue and current developments aim at the integration of several types of tissue to obtain more realistic biomimetic devices, which could lead to the next generation of hybrid robotics. Tethered bioactuators, however, result in excellent candidates for tissue models for drug screening purposes or the study of muscle myopathies due to their three-dimensional architecture.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/196622
url https://hdl.handle.net/2445/196622
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/wnan.1703
Wiley Interdisciplinary Reviews-Nanomedicine And Nanobiotechnology, 2021, vol. 13, num. 5, p. e1703
https://doi.org/10.1002/wnan.1703
dc.rights.none.fl_str_mv (c) Wiley periodicals, 2021
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley periodicals, 2021
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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