3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals

The aim of this review is to present 3D bioprinting of skin substitutes as an efficient approach of managing skin injuries. From a clinical point of view, classic treatments only provide physical protection from the environment, and existing engineered scaffolds, albeit acting as a physical support...

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Autores: Manita, Paula Gabriela, García Orúe, Itxaso, Santos Vizcaíno, Edorta, Hernández Martín, Rosa María, Igartua Olaechea, Manuela
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/51219
Acceso en línea:http://hdl.handle.net/10810/51219
Access Level:acceso abierto
Palabra clave:skin bioprinting
3D bioprinting
wounds
bioinks
tissue engineering
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spelling 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future GoalsManita, Paula GabrielaGarcía Orúe, ItxasoSantos Vizcaíno, EdortaHernández Martín, Rosa MaríaIgartua Olaechea, Manuelaskin bioprinting3D bioprintingwoundsbioinkstissue engineeringThe aim of this review is to present 3D bioprinting of skin substitutes as an efficient approach of managing skin injuries. From a clinical point of view, classic treatments only provide physical protection from the environment, and existing engineered scaffolds, albeit acting as a physical support for cells, fail to overcome needs, such as neovascularisation. In the present work, the basic principles of bioprinting, together with the most popular approaches and choices of biomaterials for 3D-printed skin construct production, are explained, as well as the main advantages over other production methods. Moreover, the development of this technology is described in a chronological manner through examples of relevant experimental work in the last two decades: from the pioneers Lee et al. to the latest advances and different innovative strategies carried out lately to overcome the well-known challenges in tissue engineering of skin. In general, this technology has a huge potential to offer, although a multidisciplinary effort is required to optimise designs, biomaterials and production processes.This research was funded by the Spanish Ministry of Economy and Competitiveness through the “RETOS” Program (NANOGROW project, RTC-2017-6696-1) and by the Basque Government (Grupos Consolidados, IT 907-16) and through the PhD grant conceded to Paula Gabriela Maniţă (PRE_2020_2_0261).MDPI2021202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/51219reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/RTC-2017-6696-1/https://www.mdpi.com/1424-8247/14/4/362/htminfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/512192026-06-18T09:23:17Z
dc.title.none.fl_str_mv 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals
title 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals
spellingShingle 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals
Manita, Paula Gabriela
skin bioprinting
3D bioprinting
wounds
bioinks
tissue engineering
title_short 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals
title_full 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals
title_fullStr 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals
title_full_unstemmed 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals
title_sort 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals
dc.creator.none.fl_str_mv Manita, Paula Gabriela
García Orúe, Itxaso
Santos Vizcaíno, Edorta
Hernández Martín, Rosa María
Igartua Olaechea, Manuela
author Manita, Paula Gabriela
author_facet Manita, Paula Gabriela
García Orúe, Itxaso
Santos Vizcaíno, Edorta
Hernández Martín, Rosa María
Igartua Olaechea, Manuela
author_role author
author2 García Orúe, Itxaso
Santos Vizcaíno, Edorta
Hernández Martín, Rosa María
Igartua Olaechea, Manuela
author2_role author
author
author
author
dc.subject.none.fl_str_mv skin bioprinting
3D bioprinting
wounds
bioinks
tissue engineering
topic skin bioprinting
3D bioprinting
wounds
bioinks
tissue engineering
description The aim of this review is to present 3D bioprinting of skin substitutes as an efficient approach of managing skin injuries. From a clinical point of view, classic treatments only provide physical protection from the environment, and existing engineered scaffolds, albeit acting as a physical support for cells, fail to overcome needs, such as neovascularisation. In the present work, the basic principles of bioprinting, together with the most popular approaches and choices of biomaterials for 3D-printed skin construct production, are explained, as well as the main advantages over other production methods. Moreover, the development of this technology is described in a chronological manner through examples of relevant experimental work in the last two decades: from the pioneers Lee et al. to the latest advances and different innovative strategies carried out lately to overcome the well-known challenges in tissue engineering of skin. In general, this technology has a huge potential to offer, although a multidisciplinary effort is required to optimise designs, biomaterials and production processes.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/51219
url http://hdl.handle.net/10810/51219
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/RTC-2017-6696-1/
https://www.mdpi.com/1424-8247/14/4/362/htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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