The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease
In Parkinson's disease, there is a progressive reduction in striatal dopaminergic function, and loss of neuromelanin-containing dopaminergic neurons and increased iron deposition in the substantia nigra. We tested the hypothesis of a relationship between impairment of the dopaminergic system an...
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:255563 |
| Acceso en línea: | https://ddd.uab.cat/record/255563 https://dx.doi.org/urn:doi:10.1093/brain/awab191 |
| Access Level: | acceso abierto |
| Palabra clave: | Parkinson's disease Neuromelanin Iron Dopamine transporter Imaging |
| id |
ES_afaa438b0439f9ae9a3c4e002eec63cf |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:255563 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's diseaseBiondetti, Emma|||0000-0001-6727-0935Santin, Mathieu D.Valabrègue, RomainMangone, GraziellaGaurav, Rahul|||0000-0001-9983-5873Pyatigorskaya, Nadya|||0000-0002-2070-1299Hutchison, MatthewYahia-Cherif, LydiaVillain, NicolasHabert, Marie-OdileArnulf, Isabelle|||0000-0002-2240-2516Leu-Semenescu, Smaranda|||0000-0001-9556-4527Dodet, PaulineVila Bover, Miquel|||0000-0002-1352-989XCorvol, Jean-Christophe|||0000-0001-7325-0199Vidailhet, MarieLehéricy, StéphaneParkinson's diseaseNeuromelaninIronDopamine transporterImagingIn Parkinson's disease, there is a progressive reduction in striatal dopaminergic function, and loss of neuromelanin-containing dopaminergic neurons and increased iron deposition in the substantia nigra. We tested the hypothesis of a relationship between impairment of the dopaminergic system and changes in the iron metabolism. Based on imaging data of patients with prodromal and early clinical Parkinson's disease, we assessed the spatiotemporal ordering of such changes and relationships in the sensorimotor, associative and limbic territories of the nigrostriatal system. Patients with Parkinson's disease (disease duration < 4 years) or idiopathic REM sleep behaviour disorder (a prodromal form of Parkinson's disease) and healthy controls underwent longitudinal examination (baseline and 2-year follow-up). Neuromelanin and iron sensitive MRI and dopamine transporter single-photon emission tomography were performed to assess nigrostriatal levels of neuromelanin, iron, and dopamine. For all three functional territories of the nigrostriatal system, in the clinically most and least affected hemispheres separately, the following was performed: cross-sectional and longitudinal intergroup difference analysis of striatal dopamine and iron, and nigral neuromelanin and iron; in Parkinson's disease patients, exponential fitting analysis to assess the duration of the prodromal phase and the temporal ordering of changes in dopamine, neuromelanin or iron relative to controls; and voxel-wise correlation analysis to investigate concomitant spatial changes in dopamine-iron, dopamine-neuromelanin and neuromelanin-iron in the substantia nigra pars compacta. The temporal ordering of dopaminergic changes followed the known spatial pattern of progression involving first the sensorimotor, then the associative and limbic striatal and nigral regions. Striatal dopaminergic denervation occurred first followed by abnormal iron metabolism and finally neuromelanin changes in the substantia nigra pars compacta, which followed the same spatial and temporal gradient observed in the striatum but shifted in time. In conclusion, dopaminergic striatal dysfunction and cell loss in the substantia nigra pars compacta are interrelated with increased nigral iron content. Using multi-modal imaging (MRI and SPECT) in patients with prodromal and early clinical Parkinson's disease, Biondetti et al. reveal dopaminergic changes, abnormal iron metabolism and neuromelanin changes first in the sensorimotor, then the associative and finally the limbic regions of the nigrostriatal systemUniversitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255563https://dx.doi.org/urn:doi:10.1093/brain/awab191reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2555632026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease |
| title |
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease |
| spellingShingle |
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease Biondetti, Emma|||0000-0001-6727-0935 Parkinson's disease Neuromelanin Iron Dopamine transporter Imaging |
| title_short |
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease |
| title_full |
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease |
| title_fullStr |
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease |
| title_full_unstemmed |
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease |
| title_sort |
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease |
| dc.creator.none.fl_str_mv |
Biondetti, Emma|||0000-0001-6727-0935 Santin, Mathieu D. Valabrègue, Romain Mangone, Graziella Gaurav, Rahul|||0000-0001-9983-5873 Pyatigorskaya, Nadya|||0000-0002-2070-1299 Hutchison, Matthew Yahia-Cherif, Lydia Villain, Nicolas Habert, Marie-Odile Arnulf, Isabelle|||0000-0002-2240-2516 Leu-Semenescu, Smaranda|||0000-0001-9556-4527 Dodet, Pauline Vila Bover, Miquel|||0000-0002-1352-989X Corvol, Jean-Christophe|||0000-0001-7325-0199 Vidailhet, Marie Lehéricy, Stéphane |
| author |
Biondetti, Emma|||0000-0001-6727-0935 |
| author_facet |
Biondetti, Emma|||0000-0001-6727-0935 Santin, Mathieu D. Valabrègue, Romain Mangone, Graziella Gaurav, Rahul|||0000-0001-9983-5873 Pyatigorskaya, Nadya|||0000-0002-2070-1299 Hutchison, Matthew Yahia-Cherif, Lydia Villain, Nicolas Habert, Marie-Odile Arnulf, Isabelle|||0000-0002-2240-2516 Leu-Semenescu, Smaranda|||0000-0001-9556-4527 Dodet, Pauline Vila Bover, Miquel|||0000-0002-1352-989X Corvol, Jean-Christophe|||0000-0001-7325-0199 Vidailhet, Marie Lehéricy, Stéphane |
| author_role |
author |
| author2 |
Santin, Mathieu D. Valabrègue, Romain Mangone, Graziella Gaurav, Rahul|||0000-0001-9983-5873 Pyatigorskaya, Nadya|||0000-0002-2070-1299 Hutchison, Matthew Yahia-Cherif, Lydia Villain, Nicolas Habert, Marie-Odile Arnulf, Isabelle|||0000-0002-2240-2516 Leu-Semenescu, Smaranda|||0000-0001-9556-4527 Dodet, Pauline Vila Bover, Miquel|||0000-0002-1352-989X Corvol, Jean-Christophe|||0000-0001-7325-0199 Vidailhet, Marie Lehéricy, Stéphane |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Parkinson's disease Neuromelanin Iron Dopamine transporter Imaging |
| topic |
Parkinson's disease Neuromelanin Iron Dopamine transporter Imaging |
| description |
In Parkinson's disease, there is a progressive reduction in striatal dopaminergic function, and loss of neuromelanin-containing dopaminergic neurons and increased iron deposition in the substantia nigra. We tested the hypothesis of a relationship between impairment of the dopaminergic system and changes in the iron metabolism. Based on imaging data of patients with prodromal and early clinical Parkinson's disease, we assessed the spatiotemporal ordering of such changes and relationships in the sensorimotor, associative and limbic territories of the nigrostriatal system. Patients with Parkinson's disease (disease duration < 4 years) or idiopathic REM sleep behaviour disorder (a prodromal form of Parkinson's disease) and healthy controls underwent longitudinal examination (baseline and 2-year follow-up). Neuromelanin and iron sensitive MRI and dopamine transporter single-photon emission tomography were performed to assess nigrostriatal levels of neuromelanin, iron, and dopamine. For all three functional territories of the nigrostriatal system, in the clinically most and least affected hemispheres separately, the following was performed: cross-sectional and longitudinal intergroup difference analysis of striatal dopamine and iron, and nigral neuromelanin and iron; in Parkinson's disease patients, exponential fitting analysis to assess the duration of the prodromal phase and the temporal ordering of changes in dopamine, neuromelanin or iron relative to controls; and voxel-wise correlation analysis to investigate concomitant spatial changes in dopamine-iron, dopamine-neuromelanin and neuromelanin-iron in the substantia nigra pars compacta. The temporal ordering of dopaminergic changes followed the known spatial pattern of progression involving first the sensorimotor, then the associative and limbic striatal and nigral regions. Striatal dopaminergic denervation occurred first followed by abnormal iron metabolism and finally neuromelanin changes in the substantia nigra pars compacta, which followed the same spatial and temporal gradient observed in the striatum but shifted in time. In conclusion, dopaminergic striatal dysfunction and cell loss in the substantia nigra pars compacta are interrelated with increased nigral iron content. Using multi-modal imaging (MRI and SPECT) in patients with prodromal and early clinical Parkinson's disease, Biondetti et al. reveal dopaminergic changes, abnormal iron metabolism and neuromelanin changes first in the sensorimotor, then the associative and finally the limbic regions of the nigrostriatal system |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/255563 https://dx.doi.org/urn:doi:10.1093/brain/awab191 |
| url |
https://ddd.uab.cat/record/255563 https://dx.doi.org/urn:doi:10.1093/brain/awab191 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869416703815843840 |
| score |
15,300724 |