Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers

Producción Científica

Detalhes bibliográficos
Autores: Acosta Rodríguez, Sergio, Quintanilla Sierra, Luis, Mbundi, Lubinda, Reboto Rodríguez, Virginia, Rodríguez Cabello, José Carlos
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2020
País:España
Recursos:Universidad de Valladolid
Repositório:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/51661
Acesso em linha:https://doi.org/10.1002/adfm.201909050
https://uvadoc.uva.es/handle/10324/51661
Access Level:Acceso aberto
Palavra-chave:Elastin-like recombinamers
Recombinantes tipo elastina
Extracellular matrix proteins
Proteínas de matriz extracelular
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spelling Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymersAcosta Rodríguez, SergioQuintanilla Sierra, LuisMbundi, LubindaReboto Rodríguez, VirginiaRodríguez Cabello, José CarlosElastin-like recombinamersRecombinantes tipo elastinaExtracellular matrix proteinsProteínas de matriz extracelularProducción CientíficaIn the development of tissue engineering strategies to replace, remodel, regenerate, or support damaged tissue, the development of bioinspired biomaterials that recapitulate the physicochemical characteristics of the extracellular matrix has received increased attention. Given the compositional heterogeneity and tissue-to-tissue variation of the extracellular matrix, the design, choice of polymer, crosslinking, and nature of the resulting biomaterials are normally depended on intended application. Generally, these biomaterials are usually made of degradable or nondegradable biomaterials that can be used as cell or drug carriers. In recent years, efforts to endow reciprocal biomaterial–cell interaction properties in scaffolds have inspired controlled synthesis, derivatization, and functionalization of the polymers used. In this regard, elastin-like recombinant proteins have generated interest and continue to be developed further owing to their modular design at a molecular level. In this review, the authors provide a summary of key extracellular matrix features relevant to biomaterials design and discuss current approaches in the development of extracellular matrix-inspired elastin-like recombinant protein based biomaterials.Comisión Europea (grants MSCA-ITN-2014-ETN-642687 and NMP-2014-646075)Gobierno de España (grants MAT2016-78903-R, MAT2015-68901-R, and RTI2018-096320-B-C22)Junta de Castilla y León (project VA317P18)"Interreg V A España Portugal" Programa operativo de cooperación transfronteriza España Portugal (POCTEP) (grant 0624_2IQBIONEURO_6_E)Wiley2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1002/adfm.201909050https://uvadoc.uva.es/handle/10324/51661reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://onlinelibrary.wiley.com/doi/10.1002/adfm.201909050info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/516612026-06-13T12:44:47Z
dc.title.none.fl_str_mv Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers
title Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers
spellingShingle Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers
Acosta Rodríguez, Sergio
Elastin-like recombinamers
Recombinantes tipo elastina
Extracellular matrix proteins
Proteínas de matriz extracelular
title_short Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers
title_full Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers
title_fullStr Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers
title_full_unstemmed Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers
title_sort Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers
dc.creator.none.fl_str_mv Acosta Rodríguez, Sergio
Quintanilla Sierra, Luis
Mbundi, Lubinda
Reboto Rodríguez, Virginia
Rodríguez Cabello, José Carlos
author Acosta Rodríguez, Sergio
author_facet Acosta Rodríguez, Sergio
Quintanilla Sierra, Luis
Mbundi, Lubinda
Reboto Rodríguez, Virginia
Rodríguez Cabello, José Carlos
author_role author
author2 Quintanilla Sierra, Luis
Mbundi, Lubinda
Reboto Rodríguez, Virginia
Rodríguez Cabello, José Carlos
author2_role author
author
author
author
dc.subject.none.fl_str_mv Elastin-like recombinamers
Recombinantes tipo elastina
Extracellular matrix proteins
Proteínas de matriz extracelular
topic Elastin-like recombinamers
Recombinantes tipo elastina
Extracellular matrix proteins
Proteínas de matriz extracelular
description Producción Científica
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1002/adfm.201909050
https://uvadoc.uva.es/handle/10324/51661
url https://doi.org/10.1002/adfm.201909050
https://uvadoc.uva.es/handle/10324/51661
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://onlinelibrary.wiley.com/doi/10.1002/adfm.201909050
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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