Electrical Stimulation of Cells: Drivers, Technology, and Effects

Published as part of Chemical Reviews special issue “Electric Fields in Chemistry and Biology”

Detalles Bibliográficos
Autores: Kadan-Jamal, Kian, Wronowski, Filip, Jin, Amy, Naegele, Tobias E., Rincón Montes, Viviana, Tao, Xudong, DomÍnguez Alfaro, Antonio, Lee, Chaeyeon, Malliaras, George G.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/404593
Acceso en línea:http://hdl.handle.net/10261/404593
https://api.elsevier.com/content/abstract/scopus_id/105013524927
Access Level:acceso abierto
Palabra clave:Cells
Electric fields
Electrical properties
Electrochemical cells
Electrodes
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spelling Electrical Stimulation of Cells: Drivers, Technology, and EffectsKadan-Jamal, KianWronowski, FilipJin, AmyNaegele, Tobias E.Rincón Montes, VivianaTao, XudongDomÍnguez Alfaro, AntonioLee, ChaeyeonMalliaras, George G.CellsElectric fieldsElectrical propertiesElectrochemical cellsElectrodesPublished as part of Chemical Reviews special issue “Electric Fields in Chemistry and Biology”Exposure of cells to electric fields is used in applications as diverse as deep brain stimulation to treat the symptoms of Parkinson's disease, tumor-treating fields to delay the progression of hard-to-treat cancers, and electroporation to deliver genetic materials to cells. It is also used to study the fundamental properties of electrically active cells and to induce changes in cell behavior, such as the directed outgrowth of neurites, that may one day find applications in the clinic. This review discusses some of the effects elicited on cells upon exposure to electric fields, both acutely and at longer time scales, and considers the underlying mechanisms proposed. It also provides an overview of the technology used to study the effects of exposure of cell to electric fields, including the different types of metal/electrolyte interfaces and the electrode materials used in in vitro and in vivo applications. The aim is to bring together concepts from different communities to highlight similarities, identify potential synergies, and create common ground that may lead to cross-fertilization and advances in the field.The authors acknowledge funding from EPSRC (IRC in Targeted Delivery for Hard-to-Treat Cancers EP/S009000/1 and program grant EP/W017091/1), a Horizon Europe UKRI underwrite Innovate grant (COPE-Nano, 10078978), and the NIHR Cambridge Biomedical Research Centre (NIHR203312). KKJ gratefully acknowledges support from the Presidential Scholarship for Postdoctoral studies for women (Tel Aviv University) and the Blavatnik Cambridge Postdoctoral Fellowship. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising.Peer reviewedAmerican Chemical SocietyEngineering and Physical Sciences Research Council (UK)European CommissionUK Research and InnovationTel Aviv UniversityCambridge Biomedical Research CentreNaegele, Tobias E. [0000-0002-1842-6750]Malliaras, George G. [0000-0002-4582-8501]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/404593https://api.elsevier.com/content/abstract/scopus_id/105013524927reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/HE/10078978https://doi.org/10.1021/acs.chemrev.4c00468Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4045932026-05-22T06:33:51Z
dc.title.none.fl_str_mv Electrical Stimulation of Cells: Drivers, Technology, and Effects
title Electrical Stimulation of Cells: Drivers, Technology, and Effects
spellingShingle Electrical Stimulation of Cells: Drivers, Technology, and Effects
Kadan-Jamal, Kian
Cells
Electric fields
Electrical properties
Electrochemical cells
Electrodes
title_short Electrical Stimulation of Cells: Drivers, Technology, and Effects
title_full Electrical Stimulation of Cells: Drivers, Technology, and Effects
title_fullStr Electrical Stimulation of Cells: Drivers, Technology, and Effects
title_full_unstemmed Electrical Stimulation of Cells: Drivers, Technology, and Effects
title_sort Electrical Stimulation of Cells: Drivers, Technology, and Effects
dc.creator.none.fl_str_mv Kadan-Jamal, Kian
Wronowski, Filip
Jin, Amy
Naegele, Tobias E.
Rincón Montes, Viviana
Tao, Xudong
DomÍnguez Alfaro, Antonio
Lee, Chaeyeon
Malliaras, George G.
author Kadan-Jamal, Kian
author_facet Kadan-Jamal, Kian
Wronowski, Filip
Jin, Amy
Naegele, Tobias E.
Rincón Montes, Viviana
Tao, Xudong
DomÍnguez Alfaro, Antonio
Lee, Chaeyeon
Malliaras, George G.
author_role author
author2 Wronowski, Filip
Jin, Amy
Naegele, Tobias E.
Rincón Montes, Viviana
Tao, Xudong
DomÍnguez Alfaro, Antonio
Lee, Chaeyeon
Malliaras, George G.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Engineering and Physical Sciences Research Council (UK)
European Commission
UK Research and Innovation
Tel Aviv University
Cambridge Biomedical Research Centre
Naegele, Tobias E. [0000-0002-1842-6750]
Malliaras, George G. [0000-0002-4582-8501]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cells
Electric fields
Electrical properties
Electrochemical cells
Electrodes
topic Cells
Electric fields
Electrical properties
Electrochemical cells
Electrodes
description Published as part of Chemical Reviews special issue “Electric Fields in Chemistry and Biology”
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/404593
https://api.elsevier.com/content/abstract/scopus_id/105013524927
url http://hdl.handle.net/10261/404593
https://api.elsevier.com/content/abstract/scopus_id/105013524927
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/HE/10078978
https://doi.org/10.1021/acs.chemrev.4c00468
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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