(Ph3P)AuCl-catalyzed homocoupling of arylboronic acids under benchtop conditions: Synthesis of biphenyls
(Ph3P)AuCl was discovered to be a powerful catalyst in the homocoupling of arylboronic acids and potassium aryltrifluoroborates for the synthesis of symmetrical biaryls. The reactions take place under benchtop reaction conditions in 96% EtOH at temperatures between rt and 50 °C with no exclusion of...
| Authors: | , , |
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| Format: | article |
| Publication Date: | 2023 |
| Country: | España |
| Institution: | Universidad Complutense de Madrid (UCM) |
| Repository: | Docta Complutense |
| Language: | English |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/105128 |
| Online Access: | https://hdl.handle.net/20.500.14352/105128 |
| Access Level: | Open access |
| Keyword: | 544.2 Gold Boronic acids Homocoupling Biphenyls Química física (Química) 2307 Química Física |
| Summary: | (Ph3P)AuCl was discovered to be a powerful catalyst in the homocoupling of arylboronic acids and potassium aryltrifluoroborates for the synthesis of symmetrical biaryls. The reactions take place under benchtop reaction conditions in 96% EtOH at temperatures between rt and 50 °C with no exclusion of air or humidity, in the presence of F-TEDA (Selectfluor™) as an oxidant. The procedure is very functional group tolerant, and affords the corresponding biaryls in high yields with large substrate scope (26 examples). |
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