Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats

No curative or fully effective treatments are currently available for Alzheimer’s disease (AD), the most common form of dementia. Electrical stimulation of deep brain areas has been proposed as a novel neuromodulatory therapeutic approach. Previous research from our lab demonstrates that intracrania...

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Authors: Puig Parnau, Irene, García-Brito, Soleil, Vila-Solés, Laia, Riberas Sánchez, Andrea, Aldavert Vera, Laura, Segura Torres, Pilar, Kádár García, Elisabeth, Huguet i Blanco, Gemma
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/22715
Online Access:http://hdl.handle.net/10256/22715
Access Level:Open access
Keyword:Neurociències
Neurosciences
Alzheimer, Malaltia d'
Alzheimer's disease
Cervell -- Estimulació
Brain stimulation
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spelling Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in RatsPuig Parnau, IreneGarcía-Brito, SoleilVila-Solés, LaiaRiberas Sánchez, AndreaAldavert Vera, LauraSegura Torres, PilarKádár García, ElisabethHuguet i Blanco, GemmaNeurociènciesNeurosciencesAlzheimer, Malaltia d'Alzheimer's diseaseCervell -- EstimulacióBrain stimulationNo curative or fully effective treatments are currently available for Alzheimer’s disease (AD), the most common form of dementia. Electrical stimulation of deep brain areas has been proposed as a novel neuromodulatory therapeutic approach. Previous research from our lab demonstrates that intracranial self-stimulation (ICSS) targeting medial forebrain bundle (MFB) facilitates explicit and implicit learning and memory in rats with age or lesion-related memory impairment. At a molecular level, MFB-ICSS modulates the expression of plasticity and neuroprotection-related genes in memory-related brain areas. On this basis, we suggest that MFB could be a promising stimulation target for AD treatment. In this study, we aimed to assess the effects of MFB-ICSS on both explicit memory as well as the levels of neuropathological markers ptau and drebrin (DBN) in memory-related areas, in an AD rat model obtained by Aβ icv-injection. A total of 36 male rats were trained in the Morris water maze on days 26–30 after Aβ injection and tested on day 33. Results demonstrate that this Aβ model displayed spatial memory impairment in the retention test, accompanied by changes in the levels of DBN and ptau in lateral entorhinal cortex and hippocampus, resembling pathological alterations in early AD. Administration of MFB-ICSS treatment consisting of 5 post-training sessions to AD rats managed to reverse the memory deficits as well as the alteration in ptau and DBN levels. Thus, this paper reports both cognitive and molecular effects of a post-training reinforcing deep brain stimulation procedure in a sporadic AD model for the first timeThis work was supported by PSI2017-83202-C2-1-P and PSI2017-83202-C2-2-P grants from Ministerio de Economía, Indústria y Competitividad (MINECO). I. Puig-Parnau was a recipient of a predoctoral fellowship from the University of Girona (IFUdG2017/61)Open Access funding provided thanks to the CRUE-CSIC agreement with Elsevier3ElsevierAgencia Estatal de Investigación2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/22715Neuroscience, 2023, vol. 512, Volume 512, p. 16-31Articles publicats (D-B)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2023.01.005info:eu-repo/semantics/altIdentifier/issn/0306-4522PSI2017-83202-C2-2-Pinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2017-83202-C2-2-PAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/227152026-05-29T05:05:01Z
dc.title.none.fl_str_mv Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats
title Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats
spellingShingle Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats
Puig Parnau, Irene
Neurociències
Neurosciences
Alzheimer, Malaltia d'
Alzheimer's disease
Cervell -- Estimulació
Brain stimulation
title_short Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats
title_full Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats
title_fullStr Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats
title_full_unstemmed Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats
title_sort Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats
dc.creator.none.fl_str_mv Puig Parnau, Irene
García-Brito, Soleil
Vila-Solés, Laia
Riberas Sánchez, Andrea
Aldavert Vera, Laura
Segura Torres, Pilar
Kádár García, Elisabeth
Huguet i Blanco, Gemma
author Puig Parnau, Irene
author_facet Puig Parnau, Irene
García-Brito, Soleil
Vila-Solés, Laia
Riberas Sánchez, Andrea
Aldavert Vera, Laura
Segura Torres, Pilar
Kádár García, Elisabeth
Huguet i Blanco, Gemma
author_role author
author2 García-Brito, Soleil
Vila-Solés, Laia
Riberas Sánchez, Andrea
Aldavert Vera, Laura
Segura Torres, Pilar
Kádár García, Elisabeth
Huguet i Blanco, Gemma
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación
dc.subject.none.fl_str_mv Neurociències
Neurosciences
Alzheimer, Malaltia d'
Alzheimer's disease
Cervell -- Estimulació
Brain stimulation
topic Neurociències
Neurosciences
Alzheimer, Malaltia d'
Alzheimer's disease
Cervell -- Estimulació
Brain stimulation
description No curative or fully effective treatments are currently available for Alzheimer’s disease (AD), the most common form of dementia. Electrical stimulation of deep brain areas has been proposed as a novel neuromodulatory therapeutic approach. Previous research from our lab demonstrates that intracranial self-stimulation (ICSS) targeting medial forebrain bundle (MFB) facilitates explicit and implicit learning and memory in rats with age or lesion-related memory impairment. At a molecular level, MFB-ICSS modulates the expression of plasticity and neuroprotection-related genes in memory-related brain areas. On this basis, we suggest that MFB could be a promising stimulation target for AD treatment. In this study, we aimed to assess the effects of MFB-ICSS on both explicit memory as well as the levels of neuropathological markers ptau and drebrin (DBN) in memory-related areas, in an AD rat model obtained by Aβ icv-injection. A total of 36 male rats were trained in the Morris water maze on days 26–30 after Aβ injection and tested on day 33. Results demonstrate that this Aβ model displayed spatial memory impairment in the retention test, accompanied by changes in the levels of DBN and ptau in lateral entorhinal cortex and hippocampus, resembling pathological alterations in early AD. Administration of MFB-ICSS treatment consisting of 5 post-training sessions to AD rats managed to reverse the memory deficits as well as the alteration in ptau and DBN levels. Thus, this paper reports both cognitive and molecular effects of a post-training reinforcing deep brain stimulation procedure in a sporadic AD model for the first time
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/22715
url http://hdl.handle.net/10256/22715
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2023.01.005
info:eu-repo/semantics/altIdentifier/issn/0306-4522
PSI2017-83202-C2-2-P
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2017-83202-C2-2-P
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Neuroscience, 2023, vol. 512, Volume 512, p. 16-31
Articles publicats (D-B)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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