Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD

Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid oxidation/secretion in the liver is a major feature of NAFLD. Given the lack...

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Detalhes bibliográficos
Autores: Martín Fernández, Marta, Arroyo, Víctor, Carnicero, Carmen, Sigüenza, Rebeca, Busta, Reyes, Mora, Natalia, Antolín, Beatriz, Tamayo, Eduardo, Aspichueta Celaá, Patricia, Carnicero Frutos, Irene, Gonzalo Benito, Hugo, Aller de la Fuente, Rocio
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/58468
Acesso em linha:http://hdl.handle.net/10810/58468
Access Level:acceso abierto
Palavra-chave:steatosis
oxidative stress
biomarkers
lipid peroxidation
NAFLD
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spelling Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLDMartín Fernández, MartaArroyo, VíctorCarnicero, CarmenSigüenza, RebecaBusta, ReyesMora, NataliaAntolín, BeatrizTamayo, EduardoAspichueta Celaá, PatriciaCarnicero Frutos, IreneGonzalo Benito, HugoAller de la Fuente, Rociosteatosisoxidative stressbiomarkerslipid peroxidationNAFLDNon-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid oxidation/secretion in the liver is a major feature of NAFLD. Given the lack of a non-invasive and reliable methods for the diagnosis of non-alcoholic steatohepatitis (NASH), it is important to find serum markers that are capable of discriminating or defining patients with this stage of NASH. Blood samples were obtained from 152 Caucasian subjects with biopsy-proven NAFLD due to persistently elevated liver enzyme levels. Metabolites representative of oxidative stress were assessed. The findings derived from this work revealed that NAFLD patients with a NASH score of ≥ 4 showed significantly higher levels of lipid peroxidation (LPO). Indeed, LPO levels above the optimal operating point (OOP) of 315.39 μM are an independent risk factor for presenting a NASH score of ≥ 4 (OR: 4.71; 95% CI: 1.68–13.19; p = 0.003). The area under the curve (AUC = 0.81, 95% CI = 0.73–0.89, p < 0.001) shows a good discrimination ability of the model. Therefore, understanding the molecular mechanisms underlying the basal inflammation present in these patients is postulated as a possible source of biomarkers and therapeutic targets in NASH.This research was funded by Consejería de Educación de Castilla y León (VA256P20), Instituto de Salud Carlos III (Grant CB21/13/0005, PI21/00917 and COV20/00491), Junta de Castilla y León (18IGOF), Gerencia Regional de Salud de Castilla y León (GRS2398/A/21), Fundación Ramón Areces (CIVP19A5953) and 7th Call for Gilead Biomedical Research Grants in HIV, Liver Diseases and Haemato-oncology.MDPI2022202220222022info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/58468reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.mdpi.com/2076-3921/11/11/2217info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/© 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).oai:addi.ehu.eus:10810/584682026-06-18T09:23:17Z
dc.title.none.fl_str_mv Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
spellingShingle Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
Martín Fernández, Marta
steatosis
oxidative stress
biomarkers
lipid peroxidation
NAFLD
title_short Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title_full Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title_fullStr Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title_full_unstemmed Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title_sort Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
dc.creator.none.fl_str_mv Martín Fernández, Marta
Arroyo, Víctor
Carnicero, Carmen
Sigüenza, Rebeca
Busta, Reyes
Mora, Natalia
Antolín, Beatriz
Tamayo, Eduardo
Aspichueta Celaá, Patricia
Carnicero Frutos, Irene
Gonzalo Benito, Hugo
Aller de la Fuente, Rocio
author Martín Fernández, Marta
author_facet Martín Fernández, Marta
Arroyo, Víctor
Carnicero, Carmen
Sigüenza, Rebeca
Busta, Reyes
Mora, Natalia
Antolín, Beatriz
Tamayo, Eduardo
Aspichueta Celaá, Patricia
Carnicero Frutos, Irene
Gonzalo Benito, Hugo
Aller de la Fuente, Rocio
author_role author
author2 Arroyo, Víctor
Carnicero, Carmen
Sigüenza, Rebeca
Busta, Reyes
Mora, Natalia
Antolín, Beatriz
Tamayo, Eduardo
Aspichueta Celaá, Patricia
Carnicero Frutos, Irene
Gonzalo Benito, Hugo
Aller de la Fuente, Rocio
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv steatosis
oxidative stress
biomarkers
lipid peroxidation
NAFLD
topic steatosis
oxidative stress
biomarkers
lipid peroxidation
NAFLD
description Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid oxidation/secretion in the liver is a major feature of NAFLD. Given the lack of a non-invasive and reliable methods for the diagnosis of non-alcoholic steatohepatitis (NASH), it is important to find serum markers that are capable of discriminating or defining patients with this stage of NASH. Blood samples were obtained from 152 Caucasian subjects with biopsy-proven NAFLD due to persistently elevated liver enzyme levels. Metabolites representative of oxidative stress were assessed. The findings derived from this work revealed that NAFLD patients with a NASH score of ≥ 4 showed significantly higher levels of lipid peroxidation (LPO). Indeed, LPO levels above the optimal operating point (OOP) of 315.39 μM are an independent risk factor for presenting a NASH score of ≥ 4 (OR: 4.71; 95% CI: 1.68–13.19; p = 0.003). The area under the curve (AUC = 0.81, 95% CI = 0.73–0.89, p < 0.001) shows a good discrimination ability of the model. Therefore, understanding the molecular mechanisms underlying the basal inflammation present in these patients is postulated as a possible source of biomarkers and therapeutic targets in NASH.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/58468
url http://hdl.handle.net/10810/58468
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2076-3921/11/11/2217
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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