Newborn electrocardiography as a screening method for long-QT syndrome

Prolongation of the QT interval is the cause of about 10% cases of sudden infant death syndrome (SIDS) innewborns but it is also responsible for about 5% of sudden deaths in adults. LQTS is associated with life threateningarrhythmias such us torsade de pointes ventricular tachycardia or ventricular...

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Autores: Torres Andrés, Francesc, Hernández Castellano, María del Cristo, García Álvarez, Juana, Martí-Almor, Julio, García Algar, Oscar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/26953
Acceso en línea:http://hdl.handle.net/10230/26953
http://dx.doi.org/10.4172/2155-9880.1000370
Access Level:acceso abierto
Palabra clave:Mort sobtada
Neonatologia
Infants nadons
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spelling Newborn electrocardiography as a screening method for long-QT syndromeTorres Andrés, FrancescHernández Castellano, María del CristoGarcía Álvarez, JuanaMartí-Almor, JulioGarcía Algar, OscarMort sobtadaNeonatologiaInfants nadonsProlongation of the QT interval is the cause of about 10% cases of sudden infant death syndrome (SIDS) innewborns but it is also responsible for about 5% of sudden deaths in adults. LQTS is associated with life threateningarrhythmias such us torsade de pointes ventricular tachycardia or ventricular fibrillation (VF) leading to suddendeath.Congenital causes (channelopathies) of LQTS are associated to mutations with different hereditary patternaccording affected gene but it has been proven that several drugs and electrolytic alterations can significantlyincrease the QT interval. However, the cost-effectiveness of neonatal electrocardiographic (EKG) screening hasbeen questioned and despite studies made in newborns there is still no consensus about the best moment to makeand electrocardiographic screening.Previous studies demonstrate that newborns with QTc values over 470 msec often normalize by themselves inthe first month of life. However in some cases these values remain high after first months of life. These cases aremore frequently in determinate ethnics (Maghreb, Morocco and India-Pakistan). These races could be linked tocardiac electrical alterations with a hereditary pattern of variable penetrance. An EKG performed in the first month oflife will allow the early identification of still asymptomatic infants with LQTS and also infants with some correctablecongenital heart defects (CHD) not recognized by routine neonatal examinations. Appropriate therapy will preventunnecessary deaths in infants, children, and young adults. At the light of this literature review we could assess thatneonatal electrocardiographic screening is highly cost-effective and it may permit the early identification of infants atrisk for SIDS.OMICS International 201620162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26953http://dx.doi.org/10.4172/2155-9880.1000370reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Clinical and Experimental Cardiology. 2015;6:370©2015 Torres F. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/269532026-05-29T05:05:01Z
dc.title.none.fl_str_mv Newborn electrocardiography as a screening method for long-QT syndrome
title Newborn electrocardiography as a screening method for long-QT syndrome
spellingShingle Newborn electrocardiography as a screening method for long-QT syndrome
Torres Andrés, Francesc
Mort sobtada
Neonatologia
Infants nadons
title_short Newborn electrocardiography as a screening method for long-QT syndrome
title_full Newborn electrocardiography as a screening method for long-QT syndrome
title_fullStr Newborn electrocardiography as a screening method for long-QT syndrome
title_full_unstemmed Newborn electrocardiography as a screening method for long-QT syndrome
title_sort Newborn electrocardiography as a screening method for long-QT syndrome
dc.creator.none.fl_str_mv Torres Andrés, Francesc
Hernández Castellano, María del Cristo
García Álvarez, Juana
Martí-Almor, Julio
García Algar, Oscar
author Torres Andrés, Francesc
author_facet Torres Andrés, Francesc
Hernández Castellano, María del Cristo
García Álvarez, Juana
Martí-Almor, Julio
García Algar, Oscar
author_role author
author2 Hernández Castellano, María del Cristo
García Álvarez, Juana
Martí-Almor, Julio
García Algar, Oscar
author2_role author
author
author
author
dc.subject.none.fl_str_mv Mort sobtada
Neonatologia
Infants nadons
topic Mort sobtada
Neonatologia
Infants nadons
description Prolongation of the QT interval is the cause of about 10% cases of sudden infant death syndrome (SIDS) innewborns but it is also responsible for about 5% of sudden deaths in adults. LQTS is associated with life threateningarrhythmias such us torsade de pointes ventricular tachycardia or ventricular fibrillation (VF) leading to suddendeath.Congenital causes (channelopathies) of LQTS are associated to mutations with different hereditary patternaccording affected gene but it has been proven that several drugs and electrolytic alterations can significantlyincrease the QT interval. However, the cost-effectiveness of neonatal electrocardiographic (EKG) screening hasbeen questioned and despite studies made in newborns there is still no consensus about the best moment to makeand electrocardiographic screening.Previous studies demonstrate that newborns with QTc values over 470 msec often normalize by themselves inthe first month of life. However in some cases these values remain high after first months of life. These cases aremore frequently in determinate ethnics (Maghreb, Morocco and India-Pakistan). These races could be linked tocardiac electrical alterations with a hereditary pattern of variable penetrance. An EKG performed in the first month oflife will allow the early identification of still asymptomatic infants with LQTS and also infants with some correctablecongenital heart defects (CHD) not recognized by routine neonatal examinations. Appropriate therapy will preventunnecessary deaths in infants, children, and young adults. At the light of this literature review we could assess thatneonatal electrocardiographic screening is highly cost-effective and it may permit the early identification of infants atrisk for SIDS.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26953
http://dx.doi.org/10.4172/2155-9880.1000370
url http://hdl.handle.net/10230/26953
http://dx.doi.org/10.4172/2155-9880.1000370
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical and Experimental Cardiology. 2015;6:370
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv OMICS International 
publisher.none.fl_str_mv OMICS International 
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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