Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder

Background: The presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson's disease (PD), but the impact of sex is unclear. We aimed to investigate sex differences in cognition and brain atrophy in PD patients with a...

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Autores: Oltra González, Javier, Segura i Fàbregas, Bàrbara, Uribe, Carme, Monté Rubio, Gemma C., Campabadal Delgado, Anna, Inguanzo, Anna, Pardo, Jèssica, Martí Domènech, Ma. Josep, Compta, Yaroslau, Valldeoriola Serra, Francesc, Iranzo, Alex, Junqué i Plaja, Carme, 1955-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183920
Acceso en línea:https://hdl.handle.net/2445/183920
Access Level:acceso abierto
Palabra clave:Cervell
Malaltia de Parkinson
Brain
Parkinson's disease
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spelling Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorderOltra González, JavierSegura i Fàbregas, BàrbaraUribe, CarmeMonté Rubio, Gemma C.Campabadal Delgado, AnnaInguanzo, AnnaPardo, JèssicaMartí Domènech, Ma. JosepCompta, YaroslauValldeoriola Serra, FrancescIranzo, AlexJunqué i Plaja, Carme, 1955-CervellMalaltia de ParkinsonBrainParkinson's diseaseBackground: The presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson's disease (PD), but the impact of sex is unclear. We aimed to investigate sex differences in cognition and brain atrophy in PD patients with and without probable RBD (pRBD). Methods: Magnetic resonance imaging and cognition data were obtained for 274 participants from the Parkinson's Progression Marker Initiative database: 79 PD with pRBD (PD-pRBD; male/female, 54/25), 126 PD without pRBD (PD-non pRBD; male/female, 73/53), and 69 healthy controls (male/female, 40/29). FreeSurfer was used to obtain volumetric and cortical thickness data. Results: Males showed greater global cortical and subcortical gray matter atrophy than females in the PD-pRBD group. Significant group-by-sex interactions were found in the pallidum. Structures showing a within-group sex effect in the deep gray matter differed, with significant volume reductions for males in one structure in in PD-non pRBD (brainstem), and three in PD-pRBD (caudate, pallidum and brainstem). Significant group-by-sex interactions were found in Montreal Cognitive Assessment (MoCA) and Symbol Digits Modalities Test (SDMT). Males performed worse than females in MoCA, phonemic fluency and SDMT in the PD-pRBD group. Conclusion: Male sex is related to increased cognitive impairment and subcortical atrophy in de novo PD-pRBD. Accordingly, we suggest that sex differences are relevant and should be considered in future clinical and translational research.Springer Verlag2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183920Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1007/s00415-021-10728-xJournal of Neurology, 2021, vol. 269, num. 3, p. 1591-1599https://doi.org/10.1007/s00415-021-10728-xinfo:eu-repo/grantAgreement/EC/H2020/888692cc-by (c) Oltra González Javier, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1839202026-05-27T06:46:51Z
dc.title.none.fl_str_mv Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder
title Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder
spellingShingle Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder
Oltra González, Javier
Cervell
Malaltia de Parkinson
Brain
Parkinson's disease
title_short Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder
title_full Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder
title_fullStr Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder
title_full_unstemmed Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder
title_sort Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder
dc.creator.none.fl_str_mv Oltra González, Javier
Segura i Fàbregas, Bàrbara
Uribe, Carme
Monté Rubio, Gemma C.
Campabadal Delgado, Anna
Inguanzo, Anna
Pardo, Jèssica
Martí Domènech, Ma. Josep
Compta, Yaroslau
Valldeoriola Serra, Francesc
Iranzo, Alex
Junqué i Plaja, Carme, 1955-
author Oltra González, Javier
author_facet Oltra González, Javier
Segura i Fàbregas, Bàrbara
Uribe, Carme
Monté Rubio, Gemma C.
Campabadal Delgado, Anna
Inguanzo, Anna
Pardo, Jèssica
Martí Domènech, Ma. Josep
Compta, Yaroslau
Valldeoriola Serra, Francesc
Iranzo, Alex
Junqué i Plaja, Carme, 1955-
author_role author
author2 Segura i Fàbregas, Bàrbara
Uribe, Carme
Monté Rubio, Gemma C.
Campabadal Delgado, Anna
Inguanzo, Anna
Pardo, Jèssica
Martí Domènech, Ma. Josep
Compta, Yaroslau
Valldeoriola Serra, Francesc
Iranzo, Alex
Junqué i Plaja, Carme, 1955-
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cervell
Malaltia de Parkinson
Brain
Parkinson's disease
topic Cervell
Malaltia de Parkinson
Brain
Parkinson's disease
description Background: The presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson's disease (PD), but the impact of sex is unclear. We aimed to investigate sex differences in cognition and brain atrophy in PD patients with and without probable RBD (pRBD). Methods: Magnetic resonance imaging and cognition data were obtained for 274 participants from the Parkinson's Progression Marker Initiative database: 79 PD with pRBD (PD-pRBD; male/female, 54/25), 126 PD without pRBD (PD-non pRBD; male/female, 73/53), and 69 healthy controls (male/female, 40/29). FreeSurfer was used to obtain volumetric and cortical thickness data. Results: Males showed greater global cortical and subcortical gray matter atrophy than females in the PD-pRBD group. Significant group-by-sex interactions were found in the pallidum. Structures showing a within-group sex effect in the deep gray matter differed, with significant volume reductions for males in one structure in in PD-non pRBD (brainstem), and three in PD-pRBD (caudate, pallidum and brainstem). Significant group-by-sex interactions were found in Montreal Cognitive Assessment (MoCA) and Symbol Digits Modalities Test (SDMT). Males performed worse than females in MoCA, phonemic fluency and SDMT in the PD-pRBD group. Conclusion: Male sex is related to increased cognitive impairment and subcortical atrophy in de novo PD-pRBD. Accordingly, we suggest that sex differences are relevant and should be considered in future clinical and translational research.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183920
url https://hdl.handle.net/2445/183920
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s00415-021-10728-x
Journal of Neurology, 2021, vol. 269, num. 3, p. 1591-1599
https://doi.org/10.1007/s00415-021-10728-x
info:eu-repo/grantAgreement/EC/H2020/888692
dc.rights.none.fl_str_mv cc-by (c) Oltra González Javier, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Oltra González Javier, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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