Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(ii) complexes

Platinum complexes, bearing aliphatic amines and phosphine ligands in trans configuration with iodide as leaving groups, are synthesized and characterized. The crystal structure of trans-PtI2(isopropylamine)(PPh3) is reported. The complex bearing isopropylamine is demonstrated to be the best candida...

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Bibliographic Details
Authors: Medrano, Angeles, Dennis, Stephen M., Álvarez-Valdés Olaguibel, María Desamparados, Perles, Josefina, McGregor Mason, Tracey, Gómez Quiroga, Adoración
Format: article
Publication Date:2015
Country:España
Institution:Universidad Autónoma de Madrid
Repository:Biblos-e Archivo. Repositorio Institucional de la UAM
Language:English
OAI Identifier:oai:repositorio.uam.es:10486/672905
Online Access:http://hdl.handle.net/10486/672905
https://dx.doi.org/10.1039/c4dt02392g
Access Level:Open access
Keyword:Cell culture
Complexation
Crystal structure
Cytotoxicity
Ligands
Phosphorus compounds
Platinum
Platinum compounds
Química
Description
Summary:Platinum complexes, bearing aliphatic amines and phosphine ligands in trans configuration with iodide as leaving groups, are synthesized and characterized. The crystal structure of trans-PtI2(isopropylamine)(PPh3) is reported. The complex bearing isopropylamine is demonstrated to be the best candidate as its cytotoxic activity is comparable to or better than cisplatin. A remarkably higher interaction of the complexes with DNA is reported as compared to the parent chlorido series. Cell cycle studies of the complexes in six human cell lines are performed and also compared with the previous series

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