Comparison of cerebral metabolic rate of oxygen, blood flow, and bispectral index under general anesthesia

The optical measurement of cerebral oxygen metabolism was evaluated. Compare optically derived cerebral signals to the electroencephalographic bispectral index (BIS) sensors to monitor propofol-induced anesthesia during surgery. Relative cerebral metabolic rate of oxygen () and blood flow (rCBF) wer...

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Detalles Bibliográficos
Autores: Tagliabue, Susanna, da Prat, Ivette Chochron, Sánchez Guerrero, Ángela, Serra Mochales, Isabel|||0000-0002-2465-8574, Kacprzak, Michał|||0000-0002-3149-837X, Maruccia, Federica|||0000-0002-3774-7875, Silva Martinez, Olga, Weigel, Udo M., Nadal Clanchet, Miriam de|||0000-0002-4559-2463, Poca Pastor, María Antonia|||0000-0002-3831-0536, Durduran, Turgut|||0000-0001-5838-1027, Lindner, Claus|||0000-0002-9878-037X
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:273225
Acceso en línea:https://ddd.uab.cat/record/273225
https://dx.doi.org/urn:doi:10.1117/1.NPh.10.1.015006
Access Level:acceso abierto
Palabra clave:Diffuse correlation spectroscopy
Time-resolved spectroscopy
Propofol-induced anesthesia
Bispectral index
Diffuse optics
Cerebral blood flow
Cerebral metabolic rate of oxygen
Cerebral physiological changes
Near-infrared spectroscopy
Descripción
Sumario:The optical measurement of cerebral oxygen metabolism was evaluated. Compare optically derived cerebral signals to the electroencephalographic bispectral index (BIS) sensors to monitor propofol-induced anesthesia during surgery. Relative cerebral metabolic rate of oxygen () and blood flow (rCBF) were measured by time-resolved and diffuse correlation spectroscopies. Changes were tested against the relative BIS (rBIS) ones. The synchronism in the changes was also assessed by the R-Pearson correlation. In 23 measurements, optically derived signals showed significant changes in agreement with rBIS: during propofol induction, rBIS decreased by 67% [interquartile ranges (IQR) 62% to 71%], by 33% (IQR 18% to 46%), and rCBF by 28% (IQR 10% to 37%). During recovery, a significant increase was observed for rBIS (48%, IQR 38% to 55%), (29%, IQR 17% to 39%), and rCBF (30%, IQR 10% to 44%). The significance and direction of the changes subject-by-subject were tested: the coupling between the rBIS, , and rCBF was witnessed in the majority of the cases (14/18 and 12/18 for rCBF and 19/21 and 13/18 for in the initial and final part, respectively). These changes were also correlated in time (to , ). Optics can reliably monitor in such conditions.

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