Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjects
Several studies suggest that coffee has some benefits for health; however, little is known about the specific role of the main polyphenol compounds of coffee, chlorogenic acids (CGAs), without caffeine interaction. A 1H-Nuclear Magnetic Resonance (1H-NMR)-based metabolomics approach was used to asse...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Estado: | Versión aceptada para publicación |
| Data de publicação: | 2016 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositório: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/108944 |
| Acesso em linha: | https://hdl.handle.net/2445/108944 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Cafè (Beguda) Ressonància magnètica nuclear Marcadors bioquímics Orina Polifenols Coffee drink Nuclear magnetic resonance Biochemical markers Urine Polyphenols |
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Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjectsMadrid Gambín, Francisco JavierGarcia Aloy, MarVázquez Fresno, RosaVegas Lozano, EstebanRuiz de Villa, CarmenMisawa, KohichiHase, TadashiShimotoyodome, AkiraAndrés Lacueva, Ma. CristinaCafè (Beguda)Ressonància magnètica nuclearMarcadors bioquímicsOrinaPolifenolsCoffee drinkNuclear magnetic resonanceBiochemical markersUrinePolyphenolsSeveral studies suggest that coffee has some benefits for health; however, little is known about the specific role of the main polyphenol compounds of coffee, chlorogenic acids (CGAs), without caffeine interaction. A 1H-Nuclear Magnetic Resonance (1H-NMR)-based metabolomics approach was used to assess the effect of CGAs from coffee on the human urine metabolome. Ten male volunteers participated in a dietary crossover randomized intervention study with a rich CGAs coffee extract beverage (CEB: 223 mg/100 ml of CGAs). The study consisted of a daily intake of CEB or a control beverage with equal caffeine dose during 28 days. Fasting urines collected at the first and last days of each period of the study were analyzed using an CGAs untargeted 1H-NMR approach. Additionally, 4-hour postpandrial urines after the first intake of each beverage were also analyzed. Uni- and multi-variate statistic approaches were used to strengthen the results. Multilevel partial least squares discriminant analysis (ML-PLS-DA) was used to paired comparisons across the crossover design. A further univariate analysis model for crossover studies was performed to assess the significant changes. Acute consumption of CEB resulted in high excretion of 2-furoylglycine, likewise endogenous compounds such as succinic, citric, 3-methyl-2-oxovaleric and isobutyric acids. Sustained consumption of CEB showed an increase of microbiota-derived compounds such as hippuric, 3-(3-Hydroxyphenyl)-3-hydroxypropionic and 3-hydroxyhippuric acids in urine. Moreover, trigonelline was found in urine after both acute and sustained intakes, as well as in the composition of the beverage exhibiting a direct excretion of this biomarker without any biotransformation, suggesting a non-interindividual variation.Elsevier B.V.2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/108944Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.foodres.2016.03.038Food Research International, 2016, vol. 89, num. 3, p. 1064-1070https://doi.org/10.1016/j.foodres.2016.03.038cc-by-nc-nd (c) Elsevier B.V., 2016http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1089442026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjects |
| title |
Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjects |
| spellingShingle |
Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjects Madrid Gambín, Francisco Javier Cafè (Beguda) Ressonància magnètica nuclear Marcadors bioquímics Orina Polifenols Coffee drink Nuclear magnetic resonance Biochemical markers Urine Polyphenols |
| title_short |
Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjects |
| title_full |
Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjects |
| title_fullStr |
Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjects |
| title_full_unstemmed |
Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjects |
| title_sort |
Impact of chlorogenic acids from coffee on urine metabolome in healthy human subjects |
| dc.creator.none.fl_str_mv |
Madrid Gambín, Francisco Javier Garcia Aloy, Mar Vázquez Fresno, Rosa Vegas Lozano, Esteban Ruiz de Villa, Carmen Misawa, Kohichi Hase, Tadashi Shimotoyodome, Akira Andrés Lacueva, Ma. Cristina |
| author |
Madrid Gambín, Francisco Javier |
| author_facet |
Madrid Gambín, Francisco Javier Garcia Aloy, Mar Vázquez Fresno, Rosa Vegas Lozano, Esteban Ruiz de Villa, Carmen Misawa, Kohichi Hase, Tadashi Shimotoyodome, Akira Andrés Lacueva, Ma. Cristina |
| author_role |
author |
| author2 |
Garcia Aloy, Mar Vázquez Fresno, Rosa Vegas Lozano, Esteban Ruiz de Villa, Carmen Misawa, Kohichi Hase, Tadashi Shimotoyodome, Akira Andrés Lacueva, Ma. Cristina |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cafè (Beguda) Ressonància magnètica nuclear Marcadors bioquímics Orina Polifenols Coffee drink Nuclear magnetic resonance Biochemical markers Urine Polyphenols |
| topic |
Cafè (Beguda) Ressonància magnètica nuclear Marcadors bioquímics Orina Polifenols Coffee drink Nuclear magnetic resonance Biochemical markers Urine Polyphenols |
| description |
Several studies suggest that coffee has some benefits for health; however, little is known about the specific role of the main polyphenol compounds of coffee, chlorogenic acids (CGAs), without caffeine interaction. A 1H-Nuclear Magnetic Resonance (1H-NMR)-based metabolomics approach was used to assess the effect of CGAs from coffee on the human urine metabolome. Ten male volunteers participated in a dietary crossover randomized intervention study with a rich CGAs coffee extract beverage (CEB: 223 mg/100 ml of CGAs). The study consisted of a daily intake of CEB or a control beverage with equal caffeine dose during 28 days. Fasting urines collected at the first and last days of each period of the study were analyzed using an CGAs untargeted 1H-NMR approach. Additionally, 4-hour postpandrial urines after the first intake of each beverage were also analyzed. Uni- and multi-variate statistic approaches were used to strengthen the results. Multilevel partial least squares discriminant analysis (ML-PLS-DA) was used to paired comparisons across the crossover design. A further univariate analysis model for crossover studies was performed to assess the significant changes. Acute consumption of CEB resulted in high excretion of 2-furoylglycine, likewise endogenous compounds such as succinic, citric, 3-methyl-2-oxovaleric and isobutyric acids. Sustained consumption of CEB showed an increase of microbiota-derived compounds such as hippuric, 3-(3-Hydroxyphenyl)-3-hydroxypropionic and 3-hydroxyhippuric acids in urine. Moreover, trigonelline was found in urine after both acute and sustained intakes, as well as in the composition of the beverage exhibiting a direct excretion of this biomarker without any biotransformation, suggesting a non-interindividual variation. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/108944 |
| url |
https://hdl.handle.net/2445/108944 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1016/j.foodres.2016.03.038 Food Research International, 2016, vol. 89, num. 3, p. 1064-1070 https://doi.org/10.1016/j.foodres.2016.03.038 |
| dc.rights.none.fl_str_mv |
cc-by-nc-nd (c) Elsevier B.V., 2016 http://creativecommons.org/licenses/by-nc-nd/3.0/es info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by-nc-nd (c) Elsevier B.V., 2016 http://creativecommons.org/licenses/by-nc-nd/3.0/es |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
| publisher.none.fl_str_mv |
Elsevier B.V. |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
| instname_str |
Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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