Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies

© 2020 by the authors.

Detalhes bibliográficos
Autores: Arboleya, Silvia, Saturio López, Silvia, Suárez, Marta, Fernández, Nuria, Mancabelli, Leonardo, González de los Reyes-Gavilán, Clara, Ventura, Marco, Solís, Gonzalo, Gueimonde Fernández, Miguel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/212543
Acesso em linha:http://hdl.handle.net/10261/212543
Access Level:acceso abierto
Palavra-chave:Bifidobacteria
ITS
Intestinal microbiota
Preterm
Mother’s own milk
Donated human milk
Early life
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spelling Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature BabiesArboleya, SilviaSaturio López, SilviaSuárez, MartaFernández, NuriaMancabelli, LeonardoGonzález de los Reyes-Gavilán, ClaraVentura, MarcoSolís, GonzaloGueimonde Fernández, MiguelBifidobacteriaITSIntestinal microbiotaPretermMother’s own milkDonated human milkEarly life© 2020 by the authors.Correct establishment of the gut microbiome is compromised in premature babies, with Bifidobacterium being one of the most affected genera. Prematurity often entails the inability to successfully breastfeed, therefore requiring the implementation of other feeding modes; breast milk expression from a donor mother is the recommended option when their own mother’s milk is not available. Some studies showed different gut microbial profiles in premature infants fed with breast milk and donor human milk, however, it is not known how this affects the species composition of the genus Bifidobacterium. The objective of this study was to assess the effect of donated human milk on shaping the gut bifidobacterial populations of premature babies during the first three months of life. We analyzed the gut bifidobacterial communities of 42 premature babies fed with human donor milk or own-mother milk by the 16S rRNA–23S rRNA internal transcriber spaces (ITS) region sequencing and q-PCR. Moreover, metabolic activity was assessed by gas chromatography. We observed a specific bifidobacterial profile based on feeding type, with higher bifidobacterial diversity in the human donor milk group. Differences in specific Bifidobacterium species composition may contribute to the development of specific new strategies or treatments aimed at mimicking the impact of own-mother milk feeding in neonatal units.This project received funding from EU Joint Programming Initiative—A Healthy Diet for a Healthy Life (JPI HDHL, http://www.healthydietforhealthylife.eu/, Spanish Ministry of Economy and Competitiveness (MINECO) Project EarlyMicroHealth), by project AGL2017-83653R from Plan Estatal de I+D+I (MINECO) and by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 749255. S.A was the recipient of a postdoctoral Juan de la Cierva Contract (Ministry of Science, Innovation and Universities, Ref. IJCI-2017-32156).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/212543reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/AGL2017-83653-RAGL2017-83653-R/AEI/10.13039/501100011033info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/IJCI-2017-32156IJCI-2017-32156/AEI/10.13039/501100011033info:eu-repo/grantAgreement/EC/H2020/749255https://doi.org/10.3390/microorganisms8050760Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2125432026-05-22T06:33:51Z
dc.title.none.fl_str_mv Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies
title Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies
spellingShingle Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies
Arboleya, Silvia
Bifidobacteria
ITS
Intestinal microbiota
Preterm
Mother’s own milk
Donated human milk
Early life
title_short Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies
title_full Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies
title_fullStr Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies
title_full_unstemmed Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies
title_sort Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies
dc.creator.none.fl_str_mv Arboleya, Silvia
Saturio López, Silvia
Suárez, Marta
Fernández, Nuria
Mancabelli, Leonardo
González de los Reyes-Gavilán, Clara
Ventura, Marco
Solís, Gonzalo
Gueimonde Fernández, Miguel
author Arboleya, Silvia
author_facet Arboleya, Silvia
Saturio López, Silvia
Suárez, Marta
Fernández, Nuria
Mancabelli, Leonardo
González de los Reyes-Gavilán, Clara
Ventura, Marco
Solís, Gonzalo
Gueimonde Fernández, Miguel
author_role author
author2 Saturio López, Silvia
Suárez, Marta
Fernández, Nuria
Mancabelli, Leonardo
González de los Reyes-Gavilán, Clara
Ventura, Marco
Solís, Gonzalo
Gueimonde Fernández, Miguel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bifidobacteria
ITS
Intestinal microbiota
Preterm
Mother’s own milk
Donated human milk
Early life
topic Bifidobacteria
ITS
Intestinal microbiota
Preterm
Mother’s own milk
Donated human milk
Early life
description © 2020 by the authors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/212543
url http://hdl.handle.net/10261/212543
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/AGL2017-83653-R
AGL2017-83653-R/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/IJCI-2017-32156
IJCI-2017-32156/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/EC/H2020/749255
https://doi.org/10.3390/microorganisms8050760
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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