The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries

Phthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive selenium species including H2Se. It is a potential compound for Se supplementation which exerts several biological effects, but its effect on the cardiovascular system is still unknown. Therefore, herein we aime...

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Autores: Balis, Peter, Berenyiova, Andrea, Misak, Anton, Grman, Marian, Rostakova, Zuzana, Waczulikova, Iveta, Cacanyiova, Sona, Domínguez-Álvarez, Enrique, Ondrias, Karol
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::88913547d254cc718227a3aa6d5113f1
Acceso en línea:http://hdl.handle.net/10261/332505
Access Level:acceso abierto
Palabra clave:Phthalic selenoanhydride
Hemodynamic parameters
Vasorelaxation
Rats
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spelling The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal ArteriesBalis, PeterBerenyiova, AndreaMisak, AntonGrman, MarianRostakova, ZuzanaWaczulikova, IvetaCacanyiova, SonaDomínguez-Álvarez, EnriqueOndrias, KarolPhthalic selenoanhydrideHemodynamic parametersVasorelaxationRatsPhthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive selenium species including H2Se. It is a potential compound for Se supplementation which exerts several biological effects, but its effect on the cardiovascular system is still unknown. Therefore, herein we aimed to study how R-Se affects rat hemodynamic parameters and vasoactive properties in isolated arteries. The right jugular vein of anesthetized Wistar male rats was cannulated for IV administration of R-Se. The arterial pulse waveform (APW) was detected by cannulation of the left carotid artery, enabling the evaluation of 35 parameters. R-Se (1–2 µmol kg−1), but not phthalic anhydride or phthalic thioanhydride, transiently modulated most of the APW parameters including a decrease in systolic and diastolic blood pressure, heart rate, dP/dtmax relative level, or anacrotic/dicrotic notches, whereas systolic area, dP/dtmin delay, dP/dtd delay, anacrotic notch relative level or its delay increased. R-Se (~10–100 µmol L−1) significantly decreased the tension of precontracted mesenteric, femoral, and renal arteries, whereas it showed a moderate vasorelaxation effect on thoracic aorta isolated from normotensive Wistar rats. The results imply that R-Se acts on vascular smooth muscle cells, which might underlie the effects of R-Se on the rat hemodynamic parameters.This research was funded by the Slovak Research & Development Agency (grant number APVV-19-0154 to K.O. and SK-BY-RD-19-0019 to I.W.); the VEGA Grant Agency of the Slovak Republic (grant numbers 2/0091/21 to A.M. and 2/0153/21 to P.B.).Peer reviewedMultidisciplinary Digital Publishing InstituteSlovak Research and Development AgencyVEGA Agency (Slovakia)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/332505reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/molecules28124826Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::88913547d254cc718227a3aa6d5113f12026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
title The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
spellingShingle The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
Balis, Peter
Phthalic selenoanhydride
Hemodynamic parameters
Vasorelaxation
Rats
title_short The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
title_full The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
title_fullStr The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
title_full_unstemmed The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
title_sort The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
dc.creator.none.fl_str_mv Balis, Peter
Berenyiova, Andrea
Misak, Anton
Grman, Marian
Rostakova, Zuzana
Waczulikova, Iveta
Cacanyiova, Sona
Domínguez-Álvarez, Enrique
Ondrias, Karol
author Balis, Peter
author_facet Balis, Peter
Berenyiova, Andrea
Misak, Anton
Grman, Marian
Rostakova, Zuzana
Waczulikova, Iveta
Cacanyiova, Sona
Domínguez-Álvarez, Enrique
Ondrias, Karol
author_role author
author2 Berenyiova, Andrea
Misak, Anton
Grman, Marian
Rostakova, Zuzana
Waczulikova, Iveta
Cacanyiova, Sona
Domínguez-Álvarez, Enrique
Ondrias, Karol
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Slovak Research and Development Agency
VEGA Agency (Slovakia)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Phthalic selenoanhydride
Hemodynamic parameters
Vasorelaxation
Rats
topic Phthalic selenoanhydride
Hemodynamic parameters
Vasorelaxation
Rats
description Phthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive selenium species including H2Se. It is a potential compound for Se supplementation which exerts several biological effects, but its effect on the cardiovascular system is still unknown. Therefore, herein we aimed to study how R-Se affects rat hemodynamic parameters and vasoactive properties in isolated arteries. The right jugular vein of anesthetized Wistar male rats was cannulated for IV administration of R-Se. The arterial pulse waveform (APW) was detected by cannulation of the left carotid artery, enabling the evaluation of 35 parameters. R-Se (1–2 µmol kg−1), but not phthalic anhydride or phthalic thioanhydride, transiently modulated most of the APW parameters including a decrease in systolic and diastolic blood pressure, heart rate, dP/dtmax relative level, or anacrotic/dicrotic notches, whereas systolic area, dP/dtmin delay, dP/dtd delay, anacrotic notch relative level or its delay increased. R-Se (~10–100 µmol L−1) significantly decreased the tension of precontracted mesenteric, femoral, and renal arteries, whereas it showed a moderate vasorelaxation effect on thoracic aorta isolated from normotensive Wistar rats. The results imply that R-Se acts on vascular smooth muscle cells, which might underlie the effects of R-Se on the rat hemodynamic parameters.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/332505
url http://hdl.handle.net/10261/332505
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/molecules28124826
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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