Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studies

This article belongs to the Special Issue Application of Immunonutrient in Human Health and Disease.

Detalhes bibliográficos
Autores: Nova, Esther, Redondo, Noemí, Martínez, Rosa M., Gómez-Martínez, Sonia, Díaz-Prieto, Ligia E., Marcos, Ascensión
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/228242
Acesso em linha:http://hdl.handle.net/10261/228242
Access Level:acceso abierto
Palavra-chave:Moringa oleifera
Diabetes mellitus
Fasting glucose
Glucose tolerance
Antioxidant enzymes
Lipid metabolism
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spelling Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studiesNova, EstherRedondo, NoemíMartínez, Rosa M.Gómez-Martínez, SoniaDíaz-Prieto, Ligia E.Marcos, AscensiónMoringa oleiferaDiabetes mellitusFasting glucoseGlucose toleranceAntioxidant enzymesLipid metabolismThis article belongs to the Special Issue Application of Immunonutrient in Human Health and Disease.Moringa oleifera (MO) is a multipurpose plant consumed as food and known for its medicinal uses, among others. Leaves, seeds and pods are the main parts used as food or food supplements. Nutritionally rich and with a high polyphenol content in the form of phenolic acids, flavonoids and glucosinolates, MO has been shown to exert numerous in vitro activities and in vivo effects, including hypoglycemic activity. A systematic search was carried out in the PubMed database and reference lists on the effects of MO on glucose metabolism. Thirty-three animal studies and eight human studies were included. Water and organic solvent extracts of leaves and, secondly, seeds, have been extensively assayed in animal models, showing the hypoglycemic effect, both under acute conditions and in long-term administrations and also prevention of other metabolic changes and complications associated to the hyperglycemic status. In humans, clinical trials are scarce, with variable designs and testing mainly dry leaf powder alone or mixed with other foods or MO aqueous preparations. Although the reported results are encouraging, especially those from postprandial studies, more human studies are certainly needed with more stringent inclusion criteria and a sufficient number of diabetic or prediabetic subjects. Moreover, trying to quantify the bioactive substances administered with the experimental material tested would facilitate comparison between studies.This work was performed under the frame of the NUTRIMOL-DB Project that received funding from the Ministerio de Economía, Industria y Competitividad (MINECO), Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, UE) (ref. AGL2017-86044-C2-1-R.).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/228242reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/AGL2017-86044-C2-1-RAGL2017-86044-C2-1-R/AEI/10.13039/501100011033https://doi.org/10.3390/nu12072050Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2282422026-05-22T06:33:51Z
dc.title.none.fl_str_mv Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studies
title Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studies
spellingShingle Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studies
Nova, Esther
Moringa oleifera
Diabetes mellitus
Fasting glucose
Glucose tolerance
Antioxidant enzymes
Lipid metabolism
title_short Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studies
title_full Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studies
title_fullStr Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studies
title_full_unstemmed Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studies
title_sort Potential of Moringa oleifera to improve glucose control for the prevention of diabetes and related metabolic alterations: A systematic review of animal and human studies
dc.creator.none.fl_str_mv Nova, Esther
Redondo, Noemí
Martínez, Rosa M.
Gómez-Martínez, Sonia
Díaz-Prieto, Ligia E.
Marcos, Ascensión
author Nova, Esther
author_facet Nova, Esther
Redondo, Noemí
Martínez, Rosa M.
Gómez-Martínez, Sonia
Díaz-Prieto, Ligia E.
Marcos, Ascensión
author_role author
author2 Redondo, Noemí
Martínez, Rosa M.
Gómez-Martínez, Sonia
Díaz-Prieto, Ligia E.
Marcos, Ascensión
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Moringa oleifera
Diabetes mellitus
Fasting glucose
Glucose tolerance
Antioxidant enzymes
Lipid metabolism
topic Moringa oleifera
Diabetes mellitus
Fasting glucose
Glucose tolerance
Antioxidant enzymes
Lipid metabolism
description This article belongs to the Special Issue Application of Immunonutrient in Human Health and Disease.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/228242
url http://hdl.handle.net/10261/228242
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/AGL2017-86044-C2-1-R
AGL2017-86044-C2-1-R/AEI/10.13039/501100011033
https://doi.org/10.3390/nu12072050
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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