Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells

© The Author(s).

Detalles Bibliográficos
Autores: Latorre, Ana, Latorre, Alfonso, Castellanos, Milagros, Rodríguez Diaz, Ciro, Lazaro-Carrillo, A., Aguado, Tania, Lecea, Mercedes, Romero-Pérez, Sonia, Calero, Macarena, Sánchez-Puelles, José María, Villanueva, Ángeles, Somoza, Álvaro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/186923
Acceso en línea:http://hdl.handle.net/10261/186923
Access Level:acceso abierto
Palabra clave:Nanomedicine
Drug delivery
Stimuli-responsive
DOX
SN38
CSCs
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spelling Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cellsLatorre, AnaLatorre, AlfonsoCastellanos, MilagrosRodríguez Diaz, CiroLazaro-Carrillo, A.Aguado, TaniaLecea, MercedesRomero-Pérez, SoniaCalero, MacarenaSánchez-Puelles, José MaríaVillanueva, ÁngelesSomoza, ÁlvaroNanomedicineDrug deliveryStimuli-responsiveDOXSN38CSCs© The Author(s).Controlled delivery of multiple chemotherapeutics can improve the effectiveness of treatments and reduce side effects and relapses. Here in, we used albumin-stabilized gold nanoclusters modified with doxorubicin and SN38 (AuNCs-DS) as combined therapy for cancer. The chemotherapeutics are conjugated to the nanostructures using linkers that release them when exposed to different internal stimuli (Glutathione and pH). This system has shown potent antitumor activity against breast and pancreatic cancer cells. Our studies indicate that the antineoplastic activity observed may be related to the reinforced DNA damage generated by the combination of the drugs. Moreover, this system presented antineoplastic activity against mammospheres, a culturing model for cancer stem cells, leading to an efficient reduction of the number of oncospheres and their size. In summary, the nanostructures reported here are promising carriers for combination therapy against cancer and particularly to cancer stem cells.his research was funded by the Spanish Ministry of Economy and Competitiveness (CTQ2016-78454-C2-2-R, SAF2014-56763-R, and SAF2017-87305-R), Comunidad de Madrid (S2013/MIT-2850), Asociación Española Contra el Cáncer, and IMDEA Nanociencia IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (MINECO, Grant SEV-2016-0686).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Comunidad de MadridConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/186923reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-78454-C2-2-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-56763-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-87305-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2016-0686S2013/MIT-2850/NANOFRONTMAG-CMhttps://doi.org/10.3390/cancers11070969Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1869232026-05-22T06:33:51Z
dc.title.none.fl_str_mv Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
title Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
spellingShingle Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
Latorre, Ana
Nanomedicine
Drug delivery
Stimuli-responsive
DOX
SN38
CSCs
title_short Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
title_full Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
title_fullStr Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
title_full_unstemmed Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
title_sort Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
dc.creator.none.fl_str_mv Latorre, Ana
Latorre, Alfonso
Castellanos, Milagros
Rodríguez Diaz, Ciro
Lazaro-Carrillo, A.
Aguado, Tania
Lecea, Mercedes
Romero-Pérez, Sonia
Calero, Macarena
Sánchez-Puelles, José María
Villanueva, Ángeles
Somoza, Álvaro
author Latorre, Ana
author_facet Latorre, Ana
Latorre, Alfonso
Castellanos, Milagros
Rodríguez Diaz, Ciro
Lazaro-Carrillo, A.
Aguado, Tania
Lecea, Mercedes
Romero-Pérez, Sonia
Calero, Macarena
Sánchez-Puelles, José María
Villanueva, Ángeles
Somoza, Álvaro
author_role author
author2 Latorre, Alfonso
Castellanos, Milagros
Rodríguez Diaz, Ciro
Lazaro-Carrillo, A.
Aguado, Tania
Lecea, Mercedes
Romero-Pérez, Sonia
Calero, Macarena
Sánchez-Puelles, José María
Villanueva, Ángeles
Somoza, Álvaro
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Comunidad de Madrid
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Nanomedicine
Drug delivery
Stimuli-responsive
DOX
SN38
CSCs
topic Nanomedicine
Drug delivery
Stimuli-responsive
DOX
SN38
CSCs
description © The Author(s).
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/186923
url http://hdl.handle.net/10261/186923
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-78454-C2-2-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-56763-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-87305-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2016-0686
S2013/MIT-2850/NANOFRONTMAG-CM
https://doi.org/10.3390/cancers11070969
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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