International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases

Fecal calprotectin (FC) is a non-invasive marker of gut inflammation which is frequently used to guide therapeutic decisions in patients with inflammatory bowel diseases (IBD). Each step of FC measurement can influence the results, leading to misinterpretations and potentially impacting the manageme...

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Autores: D'Amico, Ferdinando|||0000-0002-8591-6995, Rubin, David T., Kotze, Paulo Gustavo, Magro, Fernando|||0000-0003-2634-9668, Siegmund, Britta, Kobayashi, Taku, Olivera, Pablo A., Bossuyt, Peter|||0000-0003-4027-7365, Pouillon, Lieven|||0000-0002-3279-1033, Louis, Edouard, Domènech, Eugeni|||0000-0002-2315-7196, Ghosh, Subrata, Danese, Silvio|||0000-0001-7341-1351, Peyrin-Biroulet, Laurent
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:248150
Acceso en línea:https://ddd.uab.cat/record/248150
https://dx.doi.org/urn:doi:10.1002/ueg2.12069
Access Level:acceso abierto
Palabra clave:Fecal calprotectin
Inflammatory bowel disease
Measurement
Standardization
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spelling International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseasesD'Amico, Ferdinando|||0000-0002-8591-6995Rubin, David T.Kotze, Paulo GustavoMagro, Fernando|||0000-0003-2634-9668Siegmund, BrittaKobayashi, TakuOlivera, Pablo A.Bossuyt, Peter|||0000-0003-4027-7365Pouillon, Lieven|||0000-0002-3279-1033Louis, EdouardDomènech, Eugeni|||0000-0002-2315-7196Ghosh, SubrataDanese, Silvio|||0000-0001-7341-1351Peyrin-Biroulet, LaurentFecal calprotectinInflammatory bowel diseaseMeasurementStandardizationFecal calprotectin (FC) is a non-invasive marker of gut inflammation which is frequently used to guide therapeutic decisions in patients with inflammatory bowel diseases (IBD). Each step of FC measurement can influence the results, leading to misinterpretations and potentially impacting the management of IBD patients. To date, there is high heterogeneity between FC measurements and no current method is universally accepted as a standard. Our aim was to provide clear position statementsabout the pre-analytical and the analytical phases of FC measurement to homogenize FC levels and to minimize variability and risk of misinterpretation through aninternational consensus. Fourteen physicians with expertise in the field of IBD and FC from 11 countries attended a virtual international consensus meeting on July 17th, 2020. A systematic literature was conducted and the literature evidence was shared and discussedamong the participants. Statements were formulated, discussed, and voted. Statements were considered approved if all participants agreed. Nine statements were formulated and approved. Based on the available evidence, quantitative tests should be preferred for measuring FC. Furthermore, FC measurement, if possible, should always be performed with the same method and factors influencing FC levels should be taken into account when interpreting the results. FC has an increasingly important role in the management of patients with IBD. However, large multicenter studies should be conducted to define the reproducibility and to confirm the diagnostic accuracy of the available FC tests. FC concentrations guide clinicians' treatment decisions. Our statements have a relevant impact in daily practice and could be applied in clinical trials to standardize FC measurement. Summarise the established knowledge on this subject. What are the significant findings of this study?.Universitat Autònoma de Barcelona. Departament de Medicina 22021-01-0120212021-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/248150https://dx.doi.org/urn:doi:10.1002/ueg2.12069reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2481502026-06-06T12:50:31Z
dc.title.none.fl_str_mv International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases
title International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases
spellingShingle International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases
D'Amico, Ferdinando|||0000-0002-8591-6995
Fecal calprotectin
Inflammatory bowel disease
Measurement
Standardization
title_short International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases
title_full International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases
title_fullStr International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases
title_full_unstemmed International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases
title_sort International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases
dc.creator.none.fl_str_mv D'Amico, Ferdinando|||0000-0002-8591-6995
Rubin, David T.
Kotze, Paulo Gustavo
Magro, Fernando|||0000-0003-2634-9668
Siegmund, Britta
Kobayashi, Taku
Olivera, Pablo A.
Bossuyt, Peter|||0000-0003-4027-7365
Pouillon, Lieven|||0000-0002-3279-1033
Louis, Edouard
Domènech, Eugeni|||0000-0002-2315-7196
Ghosh, Subrata
Danese, Silvio|||0000-0001-7341-1351
Peyrin-Biroulet, Laurent
author D'Amico, Ferdinando|||0000-0002-8591-6995
author_facet D'Amico, Ferdinando|||0000-0002-8591-6995
Rubin, David T.
Kotze, Paulo Gustavo
Magro, Fernando|||0000-0003-2634-9668
Siegmund, Britta
Kobayashi, Taku
Olivera, Pablo A.
Bossuyt, Peter|||0000-0003-4027-7365
Pouillon, Lieven|||0000-0002-3279-1033
Louis, Edouard
Domènech, Eugeni|||0000-0002-2315-7196
Ghosh, Subrata
Danese, Silvio|||0000-0001-7341-1351
Peyrin-Biroulet, Laurent
author_role author
author2 Rubin, David T.
Kotze, Paulo Gustavo
Magro, Fernando|||0000-0003-2634-9668
Siegmund, Britta
Kobayashi, Taku
Olivera, Pablo A.
Bossuyt, Peter|||0000-0003-4027-7365
Pouillon, Lieven|||0000-0002-3279-1033
Louis, Edouard
Domènech, Eugeni|||0000-0002-2315-7196
Ghosh, Subrata
Danese, Silvio|||0000-0001-7341-1351
Peyrin-Biroulet, Laurent
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Medicina
dc.subject.none.fl_str_mv Fecal calprotectin
Inflammatory bowel disease
Measurement
Standardization
topic Fecal calprotectin
Inflammatory bowel disease
Measurement
Standardization
description Fecal calprotectin (FC) is a non-invasive marker of gut inflammation which is frequently used to guide therapeutic decisions in patients with inflammatory bowel diseases (IBD). Each step of FC measurement can influence the results, leading to misinterpretations and potentially impacting the management of IBD patients. To date, there is high heterogeneity between FC measurements and no current method is universally accepted as a standard. Our aim was to provide clear position statementsabout the pre-analytical and the analytical phases of FC measurement to homogenize FC levels and to minimize variability and risk of misinterpretation through aninternational consensus. Fourteen physicians with expertise in the field of IBD and FC from 11 countries attended a virtual international consensus meeting on July 17th, 2020. A systematic literature was conducted and the literature evidence was shared and discussedamong the participants. Statements were formulated, discussed, and voted. Statements were considered approved if all participants agreed. Nine statements were formulated and approved. Based on the available evidence, quantitative tests should be preferred for measuring FC. Furthermore, FC measurement, if possible, should always be performed with the same method and factors influencing FC levels should be taken into account when interpreting the results. FC has an increasingly important role in the management of patients with IBD. However, large multicenter studies should be conducted to define the reproducibility and to confirm the diagnostic accuracy of the available FC tests. FC concentrations guide clinicians' treatment decisions. Our statements have a relevant impact in daily practice and could be applied in clinical trials to standardize FC measurement. Summarise the established knowledge on this subject. What are the significant findings of this study?.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/248150
https://dx.doi.org/urn:doi:10.1002/ueg2.12069
url https://ddd.uab.cat/record/248150
https://dx.doi.org/urn:doi:10.1002/ueg2.12069
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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