Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics

Three-dimensional printing (3DP) technology enables an important improvement in the design of new drug delivery systems, such as gastroretentive floating tablets. These systems show a better temporal and spatial control of the drug release and can be customized based on individual therapeutic needs....

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Detalles Bibliográficos
Autores: Mora Castaño, Gloria, Millán Jiménez, Mónica, Caraballo, Isidoro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/144427
Acceso en línea:https://hdl.handle.net/11441/144427
https://doi.org/10.3390/pharmaceutics15030842
Access Level:acceso abierto
Palabra clave:3D printing
Gastroretentive floating tablets
High drug-loaded filaments
FDM
Affinisol™ 15LV
HPMC
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spelling Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release KineticsMora Castaño, GloriaMillán Jiménez, MónicaCaraballo, Isidoro3D printingGastroretentive floating tabletsHigh drug-loaded filamentsFDMAffinisol™ 15LVHPMCThree-dimensional printing (3DP) technology enables an important improvement in the design of new drug delivery systems, such as gastroretentive floating tablets. These systems show a better temporal and spatial control of the drug release and can be customized based on individual therapeutic needs. The aim of this work was to prepare 3DP gastroretentive floating tablets designed to provide a controlled release of the API. Metformin was used as a non-molten model drug and hydroxypropylmethyl cellulose with null or negligible toxicity was the main carrier. High drug loads were assayed. Another objective was to maintain the release kinetics as robust as possible when varying drug doses from one patient to another. Floating tablets using 10–50% w/w drug-loaded filaments were obtained by Fused Deposition Modelling (FDM) 3DP. The sealing layers of our design allowed successful buoyancy of the systems and sustained drug release for more than 8 h. Moreover, the effect of different variables on the drug release behaviour was studied. It should be highlighted that the robustness of the release kinetics was affected by varying the internal mesh size, and therefore the drug load. This could represent a step forward in the personalization of the treatments, a key advantage of 3DP technology in the pharmaceutical field.Junta de Andalucía US-1380923Ministerio de Ciencia e Innovación RTI2018-095041-B-C31, FPU18/05665Multidisciplinary Digital Publishing Institute (MDPI)Farmacia y Tecnología FarmacéuticaAgencia Estatal de Investigación. EspañaJunta de AndalucíaMinisterio de Ciencia e Innovación (MICIN). España2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/144427https://doi.org/10.3390/pharmaceutics15030842reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésPharmaceutics, 15 (3).US-1380923FPU18/05665RTI2018-095041-B-C31https://doi.org/10.3390/pharmaceutics15030842info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1444272026-06-17T12:51:07Z
dc.title.none.fl_str_mv Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
title Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
spellingShingle Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
Mora Castaño, Gloria
3D printing
Gastroretentive floating tablets
High drug-loaded filaments
FDM
Affinisol™ 15LV
HPMC
title_short Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
title_full Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
title_fullStr Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
title_full_unstemmed Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
title_sort Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
dc.creator.none.fl_str_mv Mora Castaño, Gloria
Millán Jiménez, Mónica
Caraballo, Isidoro
author Mora Castaño, Gloria
author_facet Mora Castaño, Gloria
Millán Jiménez, Mónica
Caraballo, Isidoro
author_role author
author2 Millán Jiménez, Mónica
Caraballo, Isidoro
author2_role author
author
dc.contributor.none.fl_str_mv Farmacia y Tecnología Farmacéutica
Agencia Estatal de Investigación. España
Junta de Andalucía
Ministerio de Ciencia e Innovación (MICIN). España
dc.subject.none.fl_str_mv 3D printing
Gastroretentive floating tablets
High drug-loaded filaments
FDM
Affinisol™ 15LV
HPMC
topic 3D printing
Gastroretentive floating tablets
High drug-loaded filaments
FDM
Affinisol™ 15LV
HPMC
description Three-dimensional printing (3DP) technology enables an important improvement in the design of new drug delivery systems, such as gastroretentive floating tablets. These systems show a better temporal and spatial control of the drug release and can be customized based on individual therapeutic needs. The aim of this work was to prepare 3DP gastroretentive floating tablets designed to provide a controlled release of the API. Metformin was used as a non-molten model drug and hydroxypropylmethyl cellulose with null or negligible toxicity was the main carrier. High drug loads were assayed. Another objective was to maintain the release kinetics as robust as possible when varying drug doses from one patient to another. Floating tablets using 10–50% w/w drug-loaded filaments were obtained by Fused Deposition Modelling (FDM) 3DP. The sealing layers of our design allowed successful buoyancy of the systems and sustained drug release for more than 8 h. Moreover, the effect of different variables on the drug release behaviour was studied. It should be highlighted that the robustness of the release kinetics was affected by varying the internal mesh size, and therefore the drug load. This could represent a step forward in the personalization of the treatments, a key advantage of 3DP technology in the pharmaceutical field.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/144427
https://doi.org/10.3390/pharmaceutics15030842
url https://hdl.handle.net/11441/144427
https://doi.org/10.3390/pharmaceutics15030842
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Pharmaceutics, 15 (3).
US-1380923
FPU18/05665
RTI2018-095041-B-C31
https://doi.org/10.3390/pharmaceutics15030842
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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