Genetic Susceptibility to Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignan...

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Autores: Slager, Susan L., Caporaso, Neil E., Sanjosé Llongueras, Silvia de, Goldin, Lynn R.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126406
Acceso en línea:https://hdl.handle.net/2445/126406
Access Level:acceso abierto
Palabra clave:Leucèmia limfocítica crònica
Etiologia
Chronic lymphocytic leukemia
Etiology
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spelling Genetic Susceptibility to Chronic Lymphocytic LeukemiaSlager, Susan L.Caporaso, Neil E.Sanjosé Llongueras, Silvia deGoldin, Lynn R.Leucèmia limfocítica crònicaEtiologiaChronic lymphocytic leukemiaEtiologyChronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. In the past 5 years, genome-wide association studies (GWAS) have provided the foundation for new avenues in the investigation of pathogenesis of this disease with 22 susceptibility loci currently identified. We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL. (C) 2013 Elsevier Inc. All rights reserved.Elsevier2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/126406Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1053/j.seminhematol.2013.09.007Seminars in Hematology, 2013, vol. 50, num. 4, p. 296-302https://doi.org/10.1053/j.seminhematol.2013.09.007(c) Elsevier, 2013info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1264062026-05-27T06:46:51Z
dc.title.none.fl_str_mv Genetic Susceptibility to Chronic Lymphocytic Leukemia
title Genetic Susceptibility to Chronic Lymphocytic Leukemia
spellingShingle Genetic Susceptibility to Chronic Lymphocytic Leukemia
Slager, Susan L.
Leucèmia limfocítica crònica
Etiologia
Chronic lymphocytic leukemia
Etiology
title_short Genetic Susceptibility to Chronic Lymphocytic Leukemia
title_full Genetic Susceptibility to Chronic Lymphocytic Leukemia
title_fullStr Genetic Susceptibility to Chronic Lymphocytic Leukemia
title_full_unstemmed Genetic Susceptibility to Chronic Lymphocytic Leukemia
title_sort Genetic Susceptibility to Chronic Lymphocytic Leukemia
dc.creator.none.fl_str_mv Slager, Susan L.
Caporaso, Neil E.
Sanjosé Llongueras, Silvia de
Goldin, Lynn R.
author Slager, Susan L.
author_facet Slager, Susan L.
Caporaso, Neil E.
Sanjosé Llongueras, Silvia de
Goldin, Lynn R.
author_role author
author2 Caporaso, Neil E.
Sanjosé Llongueras, Silvia de
Goldin, Lynn R.
author2_role author
author
author
dc.subject.none.fl_str_mv Leucèmia limfocítica crònica
Etiologia
Chronic lymphocytic leukemia
Etiology
topic Leucèmia limfocítica crònica
Etiologia
Chronic lymphocytic leukemia
Etiology
description Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. In the past 5 years, genome-wide association studies (GWAS) have provided the foundation for new avenues in the investigation of pathogenesis of this disease with 22 susceptibility loci currently identified. We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL. (C) 2013 Elsevier Inc. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126406
url https://hdl.handle.net/2445/126406
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1053/j.seminhematol.2013.09.007
Seminars in Hematology, 2013, vol. 50, num. 4, p. 296-302
https://doi.org/10.1053/j.seminhematol.2013.09.007
dc.rights.none.fl_str_mv (c) Elsevier, 2013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Elsevier, 2013
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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