Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity

: The aim of this work was the simultaneous loading of quercetin and mint essential oil (mint oil) in phospholipid vesicles specifically tailored to obtain an antibacterial and antioxidant mouthwash. The vesicles were prepared using soy lecithin and Tween 80 as bilayer components, and a mixture of p...

Descripción completa

Detalles Bibliográficos
Autores: Castangia, Ines, Manconi, Maria, Allaw, Mohamad, Perra, Matteo, Orrù, Germano, Fais, Sara, Scano, Alessandra, Escribano Ferrer, Elvira, Ghavam, Mansureh, Rezvani, Maryam, Manca, Maria Letizia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/185875
Acceso en línea:https://hdl.handle.net/2445/185875
Access Level:acceso abierto
Palabra clave:Olis essencials
Malalties de la boca
Estreptococs
Essences and essential oils
Mouth diseases
Streptococcus
id ES_aed362a83e466f04f2fedfd2aa7b2c8b
oai_identifier_str oai:diposit.ub.edu:2445/185875
network_acronym_str ES
network_name_str España
repository_id_str
spelling Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral CavityCastangia, InesManconi, MariaAllaw, MohamadPerra, MatteoOrrù, GermanoFais, SaraScano, AlessandraEscribano Ferrer, ElviraGhavam, MansurehRezvani, MaryamManca, Maria LetiziaOlis essencialsMalalties de la bocaEstreptococsEssences and essential oilsMouth diseasesStreptococcus: The aim of this work was the simultaneous loading of quercetin and mint essential oil (mint oil) in phospholipid vesicles specifically tailored to obtain an antibacterial and antioxidant mouthwash. The vesicles were prepared using soy lecithin and Tween 80 as bilayer components, and a mixture of phosphate buffer solution (33%), propylene glycol (33%) and ethanol (33%) as dispersing phase. The formation of regularly shaped, spherical and unilamellar vesicles was confirmed by cryogenic transmission electron microscopy analyses. Similarly, light scattering results disclosed that the size of the vesicles increased by increasing the concentration of mint oil, but at the same time the high amount of mint oil ensured high stability, as the size of these vesicles remained unchanged during 12 months of storage. All tested formulations were highly biocompatible towards epithelial cells and capable of counteracting oxidative cell damages caused by hydrogen peroxide. Moreover, the vesicles prepared with the highest concentration of mint oil inhibited the proliferation of the cariogenic Streptococcus mutans (S. mutans) and Lactobacillus acidophilus (L. acidophilus).MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/185875Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/antiox11020367Antioxidants, 2022, vol. 11, num. 367, p. 1-12https://doi.org/10.3390/antiox11020367cc-by (c) Castangia, Ines et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1858752026-05-27T06:46:51Z
dc.title.none.fl_str_mv Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity
title Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity
spellingShingle Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity
Castangia, Ines
Olis essencials
Malalties de la boca
Estreptococs
Essences and essential oils
Mouth diseases
Streptococcus
title_short Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity
title_full Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity
title_fullStr Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity
title_full_unstemmed Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity
title_sort Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity
dc.creator.none.fl_str_mv Castangia, Ines
Manconi, Maria
Allaw, Mohamad
Perra, Matteo
Orrù, Germano
Fais, Sara
Scano, Alessandra
Escribano Ferrer, Elvira
Ghavam, Mansureh
Rezvani, Maryam
Manca, Maria Letizia
author Castangia, Ines
author_facet Castangia, Ines
Manconi, Maria
Allaw, Mohamad
Perra, Matteo
Orrù, Germano
Fais, Sara
Scano, Alessandra
Escribano Ferrer, Elvira
Ghavam, Mansureh
Rezvani, Maryam
Manca, Maria Letizia
author_role author
author2 Manconi, Maria
Allaw, Mohamad
Perra, Matteo
Orrù, Germano
Fais, Sara
Scano, Alessandra
Escribano Ferrer, Elvira
Ghavam, Mansureh
Rezvani, Maryam
Manca, Maria Letizia
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Olis essencials
Malalties de la boca
Estreptococs
Essences and essential oils
Mouth diseases
Streptococcus
topic Olis essencials
Malalties de la boca
Estreptococs
Essences and essential oils
Mouth diseases
Streptococcus
description : The aim of this work was the simultaneous loading of quercetin and mint essential oil (mint oil) in phospholipid vesicles specifically tailored to obtain an antibacterial and antioxidant mouthwash. The vesicles were prepared using soy lecithin and Tween 80 as bilayer components, and a mixture of phosphate buffer solution (33%), propylene glycol (33%) and ethanol (33%) as dispersing phase. The formation of regularly shaped, spherical and unilamellar vesicles was confirmed by cryogenic transmission electron microscopy analyses. Similarly, light scattering results disclosed that the size of the vesicles increased by increasing the concentration of mint oil, but at the same time the high amount of mint oil ensured high stability, as the size of these vesicles remained unchanged during 12 months of storage. All tested formulations were highly biocompatible towards epithelial cells and capable of counteracting oxidative cell damages caused by hydrogen peroxide. Moreover, the vesicles prepared with the highest concentration of mint oil inhibited the proliferation of the cariogenic Streptococcus mutans (S. mutans) and Lactobacillus acidophilus (L. acidophilus).
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/185875
url https://hdl.handle.net/2445/185875
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antiox11020367
Antioxidants, 2022, vol. 11, num. 367, p. 1-12
https://doi.org/10.3390/antiox11020367
dc.rights.none.fl_str_mv cc-by (c) Castangia, Ines et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Castangia, Ines et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869416613903597568
score 15,300719

Similares en LA Referencia