Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.

Green space exposure during pregnancy has been associated with lower risk of adverse birth outcomes, but the biological mechanisms remain unclear. Epigenetic changes, such as DNA methylation (DNAm), may contribute to this association. The placenta, crucial for foetal development, has been understudi...

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Autores: Aguilar-Lacasaña S, Cosin-Tomas M, Raimbault B, Gómez-Herrera L, Sánchez O, Zanini MJ, Capdevila RP, Foraster M, Gascon M, Rivas I, Llurba E, Gómez-Roig MD, Sunyer J, Bustamante M, Vrijheid M, Dadvand P
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p28309
Acesso em linha:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28309
Access Level:acceso abierto
Palavra-chave:DMR
DNA methylation
EWAS
Green space
Placenta
Pregnancy
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spelling Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.Aguilar-Lacasaña SCosin-Tomas MRaimbault BGómez-Herrera LSánchez OZanini MJCapdevila RPForaster MGascon MRivas ILlurba EGómez-Roig MDSunyer JBustamante MVrijheid MDadvand PDMRDNA methylationEWASGreen spacePlacentaPregnancyGreen space exposure during pregnancy has been associated with lower risk of adverse birth outcomes, but the biological mechanisms remain unclear. Epigenetic changes, such as DNA methylation (DNAm), may contribute to this association. The placenta, crucial for foetal development, has been understudied in relation to prenatal green space exposure and DNAm on a genome-wide scale. Here, we aimed to investigate the association between green space exposure during pregnancy and epigenome-wide placental DNAm in 550 mother-child pairs from the Barcelona Life Study Cohort (BiSC) in Spain. Green space exposure was assessed as (i) residential surrounding greenness (satellite-based Normalized Difference Vegetation Index (NDVI) in buffers of 100 m, 300 m and 500 m), (ii) residential distance to the nearest major green space (meters), (iii) use of green space (hours/week), and (iv) visual access to greenery through the home window (=half of the view). Placental DNAm was measured with the EPIC array. Differentially methylated positions (DMPs) were identified using robust linear regression models adjusted for covariates, while differentially methylated regions (DMRs) were identified using the dmrff method. After Bonferroni correction, cg14852540, annotated to SLC25A10 gene, showed an inverse association with residential greenness within 500 m buffer. Additionally, 101 DMPs were suggestively significant (p-values <1 × 10(-5)) and annotated to genes involved in glucocorticoid-related pathways, inflammatory response, oxidative stress response, and oocyte maturation. No DMRs were identified. Overall, we identified an association between residential greenness and DNAm levels at one CpG in the SLC25A10 gene. Larger studies are needed to validate these findings and understand the biological pathways.ACADEMIC PRESS INC ELSEVIER SCIENCE2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28309ENVIRONMENTAL RESEARCHISSN: 00139351ISSNe: 10960953reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p283092026-05-27T12:37:41Z
dc.title.none.fl_str_mv Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.
title Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.
spellingShingle Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.
Aguilar-Lacasaña S
DMR
DNA methylation
EWAS
Green space
Placenta
Pregnancy
title_short Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.
title_full Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.
title_fullStr Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.
title_full_unstemmed Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.
title_sort Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.
dc.creator.none.fl_str_mv Aguilar-Lacasaña S
Cosin-Tomas M
Raimbault B
Gómez-Herrera L
Sánchez O
Zanini MJ
Capdevila RP
Foraster M
Gascon M
Rivas I
Llurba E
Gómez-Roig MD
Sunyer J
Bustamante M
Vrijheid M
Dadvand P
author Aguilar-Lacasaña S
author_facet Aguilar-Lacasaña S
Cosin-Tomas M
Raimbault B
Gómez-Herrera L
Sánchez O
Zanini MJ
Capdevila RP
Foraster M
Gascon M
Rivas I
Llurba E
Gómez-Roig MD
Sunyer J
Bustamante M
Vrijheid M
Dadvand P
author_role author
author2 Cosin-Tomas M
Raimbault B
Gómez-Herrera L
Sánchez O
Zanini MJ
Capdevila RP
Foraster M
Gascon M
Rivas I
Llurba E
Gómez-Roig MD
Sunyer J
Bustamante M
Vrijheid M
Dadvand P
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DMR
DNA methylation
EWAS
Green space
Placenta
Pregnancy
topic DMR
DNA methylation
EWAS
Green space
Placenta
Pregnancy
description Green space exposure during pregnancy has been associated with lower risk of adverse birth outcomes, but the biological mechanisms remain unclear. Epigenetic changes, such as DNA methylation (DNAm), may contribute to this association. The placenta, crucial for foetal development, has been understudied in relation to prenatal green space exposure and DNAm on a genome-wide scale. Here, we aimed to investigate the association between green space exposure during pregnancy and epigenome-wide placental DNAm in 550 mother-child pairs from the Barcelona Life Study Cohort (BiSC) in Spain. Green space exposure was assessed as (i) residential surrounding greenness (satellite-based Normalized Difference Vegetation Index (NDVI) in buffers of 100 m, 300 m and 500 m), (ii) residential distance to the nearest major green space (meters), (iii) use of green space (hours/week), and (iv) visual access to greenery through the home window (=half of the view). Placental DNAm was measured with the EPIC array. Differentially methylated positions (DMPs) were identified using robust linear regression models adjusted for covariates, while differentially methylated regions (DMRs) were identified using the dmrff method. After Bonferroni correction, cg14852540, annotated to SLC25A10 gene, showed an inverse association with residential greenness within 500 m buffer. Additionally, 101 DMPs were suggestively significant (p-values <1 × 10(-5)) and annotated to genes involved in glucocorticoid-related pathways, inflammatory response, oxidative stress response, and oocyte maturation. No DMRs were identified. Overall, we identified an association between residential greenness and DNAm levels at one CpG in the SLC25A10 gene. Larger studies are needed to validate these findings and understand the biological pathways.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28309
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28309
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ACADEMIC PRESS INC ELSEVIER SCIENCE
publisher.none.fl_str_mv ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.source.none.fl_str_mv ENVIRONMENTAL RESEARCH
ISSN: 00139351
ISSNe: 10960953
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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