The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits

It is assumed that the claustrum (CL) is involved in sensorimotor integration and cognitive processes.We recorded the firing activity of identified CL neurons during classical eyeblink conditioning in rabbits, using a delay paradigm in which a tone was presented as conditioned stimulus (CS), followe...

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Detalles Bibliográficos
Autores: Reus-García, M. Mar, Sánchez-Campusano, Raudel, Ledderose, J., Dogbevia, G.K., Treviño, M., Hasan, M.T., Gruart, Agnès, Delgado-García, J.M.
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Pablo de Olavide (UPO)
Repositorio:RIO. Repositorio Institucional Olavide
Idioma:inglés
OAI Identifier:oai:rio.upo.es:10433/19870
Acceso en línea:https://hdl.handle.net/10433/19870
Access Level:acceso abierto
Palabra clave:Claustrum
Classical eyeblink conditioning
Local Field Potentials
Rabbits
Unitary recording
Virus-delivered inducible silencing of synaptic transmission
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spelling The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbitsReus-García, M. MarSánchez-Campusano, RaudelLedderose, J.Dogbevia, G.K.Treviño, M.Hasan, M.T.Gruart, AgnèsDelgado-García, J.M.ClaustrumClassical eyeblink conditioningLocal Field PotentialsRabbitsUnitary recordingVirus-delivered inducible silencing of synaptic transmissionIt is assumed that the claustrum (CL) is involved in sensorimotor integration and cognitive processes.We recorded the firing activity of identified CL neurons during classical eyeblink conditioning in rabbits, using a delay paradigm in which a tone was presented as conditioned stimulus (CS), followed by a corneal air puff as unconditioned stimulus (US). Neurons were identified by their activation from motor (MC), cingulate (CC), and medial prefrontal (mPFC) cortices. CL neurons were rarely activated by single stimuli of any modality. In contrast, their firing was significantly modulated during the first sessions of paired CS/US presentations, but not in well-trained animals. Neuron firing rates did not correlate with the kinematics of conditioned responses (CRs). CL local field potentials (LFPs) changed their spectral power across learning and presented well-differentiated CL–mPFC/CL–MC network dynamics, as shown by crossfrequency spectral measurements. CL electrical stimulation did not evoke eyelid responses, even in trained animals. Silencing of synaptic transmission of CL neurons by the vINSIST method delayed the acquisition of CRs but did not affect their presentation rate. The CL plays an important role in the acquisition of associative learning,mostly in relation to the novelty of CS/US association, but not in the expression of CRs.Oxford University Press20242024-02-0720212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10433/19870reponame:RIO. Repositorio Institucional Olavideinstname:Universidad Pablo de Olavide (UPO)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:rio.upo.es:10433/198702026-06-13T12:46:27Z
dc.title.none.fl_str_mv The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits
title The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits
spellingShingle The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits
Reus-García, M. Mar
Claustrum
Classical eyeblink conditioning
Local Field Potentials
Rabbits
Unitary recording
Virus-delivered inducible silencing of synaptic transmission
title_short The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits
title_full The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits
title_fullStr The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits
title_full_unstemmed The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits
title_sort The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits
dc.creator.none.fl_str_mv Reus-García, M. Mar
Sánchez-Campusano, Raudel
Ledderose, J.
Dogbevia, G.K.
Treviño, M.
Hasan, M.T.
Gruart, Agnès
Delgado-García, J.M.
author Reus-García, M. Mar
author_facet Reus-García, M. Mar
Sánchez-Campusano, Raudel
Ledderose, J.
Dogbevia, G.K.
Treviño, M.
Hasan, M.T.
Gruart, Agnès
Delgado-García, J.M.
author_role author
author2 Sánchez-Campusano, Raudel
Ledderose, J.
Dogbevia, G.K.
Treviño, M.
Hasan, M.T.
Gruart, Agnès
Delgado-García, J.M.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Claustrum
Classical eyeblink conditioning
Local Field Potentials
Rabbits
Unitary recording
Virus-delivered inducible silencing of synaptic transmission
topic Claustrum
Classical eyeblink conditioning
Local Field Potentials
Rabbits
Unitary recording
Virus-delivered inducible silencing of synaptic transmission
description It is assumed that the claustrum (CL) is involved in sensorimotor integration and cognitive processes.We recorded the firing activity of identified CL neurons during classical eyeblink conditioning in rabbits, using a delay paradigm in which a tone was presented as conditioned stimulus (CS), followed by a corneal air puff as unconditioned stimulus (US). Neurons were identified by their activation from motor (MC), cingulate (CC), and medial prefrontal (mPFC) cortices. CL neurons were rarely activated by single stimuli of any modality. In contrast, their firing was significantly modulated during the first sessions of paired CS/US presentations, but not in well-trained animals. Neuron firing rates did not correlate with the kinematics of conditioned responses (CRs). CL local field potentials (LFPs) changed their spectral power across learning and presented well-differentiated CL–mPFC/CL–MC network dynamics, as shown by crossfrequency spectral measurements. CL electrical stimulation did not evoke eyelid responses, even in trained animals. Silencing of synaptic transmission of CL neurons by the vINSIST method delayed the acquisition of CRs but did not affect their presentation rate. The CL plays an important role in the acquisition of associative learning,mostly in relation to the novelty of CS/US association, but not in the expression of CRs.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
2024
2024-02-07
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10433/19870
url https://hdl.handle.net/10433/19870
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:RIO. Repositorio Institucional Olavide
instname:Universidad Pablo de Olavide (UPO)
instname_str Universidad Pablo de Olavide (UPO)
reponame_str RIO. Repositorio Institucional Olavide
collection RIO. Repositorio Institucional Olavide
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869416612775329792
score 15,300719

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