Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)

BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS:...

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Detalles Bibliográficos
Autores: Castro Giner, Francesc, Künzli, Nino, Jacquemin Leonard, Bénédicte, Forsberg, Bertil, Cid Ibeas, Rafael de, Sunyer Deu, Jordi, Jarvis, Deborah, Briggs, David, Vienneau, Danielle, Norbäck, Dan, González, Juan Ramón, Guerra, Stefano, Janson, Christer, Antó i Boqué, Josep Maria, Wjst, Matthias, Heinrich, Joachim, Estivill, Xavier, 1955-, Kogevinas, Manolis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/41970
Acceso en línea:http://hdl.handle.net/10230/41970
http://dx.doi.org/10.1289/ehp.0900589
Access Level:acceso abierto
Palabra clave:Asma
Estrès oxidatiu
Genètica
Aire -- Contaminació
Automòbils -- Aspectes ambientals
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spelling Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)Castro Giner, FrancescKünzli, NinoJacquemin Leonard, BénédicteForsberg, BertilCid Ibeas, Rafael deSunyer Deu, JordiJarvis, DeborahBriggs, DavidVienneau, DanielleNorbäck, DanGonzález, Juan RamónGuerra, StefanoJanson, ChristerAntó i Boqué, Josep MariaWjst, MatthiasHeinrich, JoachimEstivill, Xavier, 1955-Kogevinas, ManolisAsmaEstrès oxidatiuGenèticaAire -- ContaminacióAutomòbils -- Aspectes ambientalsBACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO(2) estimates were available. Home addresses were geocoded and linked to modeled outdoor NO(2) estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor alpha (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor beta2 (ADRB2)]. RESULTS: The association between modeled NO(2) and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO(2) was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO(2) for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.This work was supported by grants from MaratoTV3, Catalonia, Spain, and from Genome Spain. Additional funding was available in each research center for data collectionNational Institute of Environmental Health Sciences (NIEHS)201920192009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/41970http://dx.doi.org/10.1289/ehp.0900589reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEnvironmental Health Perspectives. 2009 Dec;117(12):1919-24Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, "Reproduced with permission from Environmental Health Perspectives"); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyrightinfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/419702026-05-29T05:05:01Z
dc.title.none.fl_str_mv Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
title Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
spellingShingle Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
Castro Giner, Francesc
Asma
Estrès oxidatiu
Genètica
Aire -- Contaminació
Automòbils -- Aspectes ambientals
title_short Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
title_full Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
title_fullStr Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
title_full_unstemmed Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
title_sort Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
dc.creator.none.fl_str_mv Castro Giner, Francesc
Künzli, Nino
Jacquemin Leonard, Bénédicte
Forsberg, Bertil
Cid Ibeas, Rafael de
Sunyer Deu, Jordi
Jarvis, Deborah
Briggs, David
Vienneau, Danielle
Norbäck, Dan
González, Juan Ramón
Guerra, Stefano
Janson, Christer
Antó i Boqué, Josep Maria
Wjst, Matthias
Heinrich, Joachim
Estivill, Xavier, 1955-
Kogevinas, Manolis
author Castro Giner, Francesc
author_facet Castro Giner, Francesc
Künzli, Nino
Jacquemin Leonard, Bénédicte
Forsberg, Bertil
Cid Ibeas, Rafael de
Sunyer Deu, Jordi
Jarvis, Deborah
Briggs, David
Vienneau, Danielle
Norbäck, Dan
González, Juan Ramón
Guerra, Stefano
Janson, Christer
Antó i Boqué, Josep Maria
Wjst, Matthias
Heinrich, Joachim
Estivill, Xavier, 1955-
Kogevinas, Manolis
author_role author
author2 Künzli, Nino
Jacquemin Leonard, Bénédicte
Forsberg, Bertil
Cid Ibeas, Rafael de
Sunyer Deu, Jordi
Jarvis, Deborah
Briggs, David
Vienneau, Danielle
Norbäck, Dan
González, Juan Ramón
Guerra, Stefano
Janson, Christer
Antó i Boqué, Josep Maria
Wjst, Matthias
Heinrich, Joachim
Estivill, Xavier, 1955-
Kogevinas, Manolis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Asma
Estrès oxidatiu
Genètica
Aire -- Contaminació
Automòbils -- Aspectes ambientals
topic Asma
Estrès oxidatiu
Genètica
Aire -- Contaminació
Automòbils -- Aspectes ambientals
description BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO(2) estimates were available. Home addresses were geocoded and linked to modeled outdoor NO(2) estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor alpha (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor beta2 (ADRB2)]. RESULTS: The association between modeled NO(2) and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO(2) was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO(2) for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.
publishDate 2009
dc.date.none.fl_str_mv 2009
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/41970
http://dx.doi.org/10.1289/ehp.0900589
url http://hdl.handle.net/10230/41970
http://dx.doi.org/10.1289/ehp.0900589
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environmental Health Perspectives. 2009 Dec;117(12):1919-24
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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