Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patients

Background: Global longitudinal strain (GLS) allows an accurate assessment of left ventricular function with prognostic value. We aimed to evaluate whether the assessment of GLS in the acute phase of Takotsubo syndrome (TTS) provides incremental prognostic value to the degree of impaired microvascul...

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Authors: Sans-Rosello, J, Fernandez-Peregrina, E, Duran-Cambra, A, Carreras-Mora, J, Sionis, A, Alvarez-Garcia, J, Garcia-Garcia, HM
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repository:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p1609
Online Access:https://i3pt.portalinvestigacion.com/publicaciones/1609
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145693710&doi=10.1007%2fs10554-022-02767-w&partnerID=40&md5=0df1b39acf603c5d0f10e507bd6c1a0f
Access Level:Open access
Keyword:Global longitudinal strain
Coronary microvascular dysfunction
Microvascular resistance
Takotsubo cardiomyopathy
Index of microcirculatory resistance
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spelling Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patientsSans-Rosello, JFernandez-Peregrina, EDuran-Cambra, ACarreras-Mora, JSionis, AAlvarez-Garcia, JGarcia-Garcia, HMGlobal longitudinal strainCoronary microvascular dysfunctionMicrovascular resistanceTakotsubo cardiomyopathyIndex of microcirculatory resistanceBackground: Global longitudinal strain (GLS) allows an accurate assessment of left ventricular function with prognostic value. We aimed to evaluate whether the assessment of GLS in the acute phase of Takotsubo syndrome (TTS) provides incremental prognostic value to the degree of impaired microvascular resistance (MR) in TTS patients at 1-year follow-up. Methods: We recruited patients admitted for TTS who underwent cardiac angiography and echocardiography from January 2017 to June 2020. Left anterior descending coronary artery non-hyperaemic angiography-derived index of microcirculatory resistance (LAD NH-IMRangio) was calculated. NT-proBNP, high-sensitive cardiac troponin T (hs-cTnT), left ventricular ejection fraction (LVEF) and GLS were measured at admission. Major adverse cardiac events (MACE) were defined as the composite of cardiovascular death, repeat hospitalizations for heart failure (HF) and acute myocardial infarctions. Results: 67 patients had both GLS and NH-IMRangio available and were included in the study. Median age was 75.2 years and 88% were women. Rate of MACE at 1-year was 13.4%. Kaplan-Meier curves showed higher rates of MACE at 1-year in patients with both higher LAD NH-IMRangio and GLS values compared with those with higher LAD NH-IMRangio and lower GLS values (33.3% vs. 11.1%; p = 0.049). NT-proBNP levels at admission and the recovery of LVEF were correlated with GLS values while MR and hs-cTnT were not. Conclusion: GLS provides incremental prognostic value to the degree of impaired MR in TTS patients. The combination of a poorer GLS with a higher degree of impaired MR was associated with a higher rate of MACE in these patients.SPRINGER2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/1609https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145693710&doi=10.1007%2fs10554-022-02767-w&partnerID=40&md5=0df1b39acf603c5d0f10e507bd6c1a0fINTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGINGISSN: 15695794ISSNe: 18758312reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p16092026-06-21T15:30:37Z
dc.title.none.fl_str_mv Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patients
title Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patients
spellingShingle Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patients
Sans-Rosello, J
Global longitudinal strain
Coronary microvascular dysfunction
Microvascular resistance
Takotsubo cardiomyopathy
Index of microcirculatory resistance
title_short Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patients
title_full Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patients
title_fullStr Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patients
title_full_unstemmed Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patients
title_sort Incremental prognostic value of global longitudinal strain to the coronary microvascular resistances in Takotsubo patients
dc.creator.none.fl_str_mv Sans-Rosello, J
Fernandez-Peregrina, E
Duran-Cambra, A
Carreras-Mora, J
Sionis, A
Alvarez-Garcia, J
Garcia-Garcia, HM
author Sans-Rosello, J
author_facet Sans-Rosello, J
Fernandez-Peregrina, E
Duran-Cambra, A
Carreras-Mora, J
Sionis, A
Alvarez-Garcia, J
Garcia-Garcia, HM
author_role author
author2 Fernandez-Peregrina, E
Duran-Cambra, A
Carreras-Mora, J
Sionis, A
Alvarez-Garcia, J
Garcia-Garcia, HM
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Global longitudinal strain
Coronary microvascular dysfunction
Microvascular resistance
Takotsubo cardiomyopathy
Index of microcirculatory resistance
topic Global longitudinal strain
Coronary microvascular dysfunction
Microvascular resistance
Takotsubo cardiomyopathy
Index of microcirculatory resistance
description Background: Global longitudinal strain (GLS) allows an accurate assessment of left ventricular function with prognostic value. We aimed to evaluate whether the assessment of GLS in the acute phase of Takotsubo syndrome (TTS) provides incremental prognostic value to the degree of impaired microvascular resistance (MR) in TTS patients at 1-year follow-up. Methods: We recruited patients admitted for TTS who underwent cardiac angiography and echocardiography from January 2017 to June 2020. Left anterior descending coronary artery non-hyperaemic angiography-derived index of microcirculatory resistance (LAD NH-IMRangio) was calculated. NT-proBNP, high-sensitive cardiac troponin T (hs-cTnT), left ventricular ejection fraction (LVEF) and GLS were measured at admission. Major adverse cardiac events (MACE) were defined as the composite of cardiovascular death, repeat hospitalizations for heart failure (HF) and acute myocardial infarctions. Results: 67 patients had both GLS and NH-IMRangio available and were included in the study. Median age was 75.2 years and 88% were women. Rate of MACE at 1-year was 13.4%. Kaplan-Meier curves showed higher rates of MACE at 1-year in patients with both higher LAD NH-IMRangio and GLS values compared with those with higher LAD NH-IMRangio and lower GLS values (33.3% vs. 11.1%; p = 0.049). NT-proBNP levels at admission and the recovery of LVEF were correlated with GLS values while MR and hs-cTnT were not. Conclusion: GLS provides incremental prognostic value to the degree of impaired MR in TTS patients. The combination of a poorer GLS with a higher degree of impaired MR was associated with a higher rate of MACE in these patients.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/1609
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145693710&doi=10.1007%2fs10554-022-02767-w&partnerID=40&md5=0df1b39acf603c5d0f10e507bd6c1a0f
url https://i3pt.portalinvestigacion.com/publicaciones/1609
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145693710&doi=10.1007%2fs10554-022-02767-w&partnerID=40&md5=0df1b39acf603c5d0f10e507bd6c1a0f
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER
publisher.none.fl_str_mv SPRINGER
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
ISSN: 15695794
ISSNe: 18758312
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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