Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats

Intensive exercise can lead to oxidative stress, which can be particularly deleterious for lymphoid tissues. Hesperidin has demonstrated its antioxidant activity, but few studies focus on its influence on intensive training. The aim of this study was to assess the impact of hesperidin on the oxidant...

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Authors: Estruel Amades, Seila, Massot Cladera, Malen, Garcia-Cerdà, Pau, Pérez-Cano, Francisco J., Franch i Masferrer, Àngels, Castell, Margarida, Camps i Bossacoma, Mariona
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/168817
Online Access:https://hdl.handle.net/2445/168817
Access Level:Open access
Keyword:Condició física
Fatiga
Efecte de l'estrès sobre els animals
Rates (Animals de laboratori)
Physical fitness
Fatigue
Effect of stress on animals
Rats as laboratory animals
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spelling Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained RatsEstruel Amades, SeilaMassot Cladera, MalenGarcia-Cerdà, PauPérez-Cano, Francisco J.Franch i Masferrer, ÀngelsCastell, MargaridaCamps i Bossacoma, MarionaCondició físicaFatigaEfecte de l'estrès sobre els animalsRates (Animals de laboratori)Physical fitnessFatigueEffect of stress on animalsRats as laboratory animalsIntensive exercise can lead to oxidative stress, which can be particularly deleterious for lymphoid tissues. Hesperidin has demonstrated its antioxidant activity, but few studies focus on its influence on intensive training. The aim of this study was to assess the impact of hesperidin on the oxidant/antioxidant status of lymphoid tissues after an intensive training program. Wistar rats were trained for five weeks (five days per week), including two exhaustion tests plus three trainings per week. During this period, animals were orally administrated with 200 mg/kg of hesperidin or vehicle (three days per week). The oxidative status was determined before, immediately after and 24 h after an additional exhaustion test. The production of reactive oxygen species (ROS) by peritoneal macrophages, superoxide dismutase (SOD) and catalase activities in spleen, thymus and liver, and hepatic glutathione peroxidase activity (GPx) were assessed. Hesperidin prevented an increase in ROS production induced by the additional exhaustion test. Likewise, hesperidin avoided a decrease in SOD and catalase activities in the thymus and spleen that was found after the additional exhaustion test. The antioxidant effects of hesperidin were associated with a higher performance in the assessed training model. These results suggest that hesperidin, acting as an antioxidant, can prevent oxidative stress induced by exercise and improve exercise performance.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/168817Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/nu11040783Nutrients, 2019, vol. 11, num. 4https://doi.org/10.3390/nu11040783cc-by (c) Estruel Amades, Seila et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1688172026-05-27T06:46:51Z
dc.title.none.fl_str_mv Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats
title Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats
spellingShingle Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats
Estruel Amades, Seila
Condició física
Fatiga
Efecte de l'estrès sobre els animals
Rates (Animals de laboratori)
Physical fitness
Fatigue
Effect of stress on animals
Rats as laboratory animals
title_short Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats
title_full Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats
title_fullStr Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats
title_full_unstemmed Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats
title_sort Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats
dc.creator.none.fl_str_mv Estruel Amades, Seila
Massot Cladera, Malen
Garcia-Cerdà, Pau
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
Castell, Margarida
Camps i Bossacoma, Mariona
author Estruel Amades, Seila
author_facet Estruel Amades, Seila
Massot Cladera, Malen
Garcia-Cerdà, Pau
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
Castell, Margarida
Camps i Bossacoma, Mariona
author_role author
author2 Massot Cladera, Malen
Garcia-Cerdà, Pau
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
Castell, Margarida
Camps i Bossacoma, Mariona
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Condició física
Fatiga
Efecte de l'estrès sobre els animals
Rates (Animals de laboratori)
Physical fitness
Fatigue
Effect of stress on animals
Rats as laboratory animals
topic Condició física
Fatiga
Efecte de l'estrès sobre els animals
Rates (Animals de laboratori)
Physical fitness
Fatigue
Effect of stress on animals
Rats as laboratory animals
description Intensive exercise can lead to oxidative stress, which can be particularly deleterious for lymphoid tissues. Hesperidin has demonstrated its antioxidant activity, but few studies focus on its influence on intensive training. The aim of this study was to assess the impact of hesperidin on the oxidant/antioxidant status of lymphoid tissues after an intensive training program. Wistar rats were trained for five weeks (five days per week), including two exhaustion tests plus three trainings per week. During this period, animals were orally administrated with 200 mg/kg of hesperidin or vehicle (three days per week). The oxidative status was determined before, immediately after and 24 h after an additional exhaustion test. The production of reactive oxygen species (ROS) by peritoneal macrophages, superoxide dismutase (SOD) and catalase activities in spleen, thymus and liver, and hepatic glutathione peroxidase activity (GPx) were assessed. Hesperidin prevented an increase in ROS production induced by the additional exhaustion test. Likewise, hesperidin avoided a decrease in SOD and catalase activities in the thymus and spleen that was found after the additional exhaustion test. The antioxidant effects of hesperidin were associated with a higher performance in the assessed training model. These results suggest that hesperidin, acting as an antioxidant, can prevent oxidative stress induced by exercise and improve exercise performance.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/168817
url https://hdl.handle.net/2445/168817
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu11040783
Nutrients, 2019, vol. 11, num. 4
https://doi.org/10.3390/nu11040783
dc.rights.none.fl_str_mv cc-by (c) Estruel Amades, Seila et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Estruel Amades, Seila et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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