Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome

[Background] Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS.

Detalles Bibliográficos
Autores: Aranha, Mateus Rozalem, Iulita, Maria Florencia, Montal, Victor, Pegueroles, Jordi, Bejanin, Alexandre, Vaqué-Alcázar, Lídia, Grothe, Michel J., Carmona-Iragui, Maria, Videla, Laura, Benejam, Bessy, Arranz, Javier, Padilla, Concepción, Valldeneu, Sílvia, Barroeta, Isabel, Altuna, Miren, Fernández, Susana, Ribas, Laia, Valle-Tamayo, Natalia, Alcolea, Daniel, González-Ortiz, Sofía, Bargalló, Núria, Zetterberg, Henrik, Blennow, Kaj, Blesa, Rafael, Wisniewski, Thomas, Busciglio, Jorge, Cuello, A. Claudio, Lleó, Alberto, Fortea, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/353534
Acceso en línea:http://hdl.handle.net/10261/353534
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Basal forebrain
Biomarkers
Cholinergic
Down syndrome
Magnetic resonance imaging
Neuroimaging
Volumetry
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dc.title.none.fl_str_mv Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
spellingShingle Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
Aranha, Mateus Rozalem
Alzheimer's disease
Basal forebrain
Biomarkers
Cholinergic
Down syndrome
Magnetic resonance imaging
Neuroimaging
Volumetry
title_short Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title_full Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title_fullStr Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title_full_unstemmed Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title_sort Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
dc.creator.none.fl_str_mv Aranha, Mateus Rozalem
Iulita, Maria Florencia
Montal, Victor
Pegueroles, Jordi
Bejanin, Alexandre
Vaqué-Alcázar, Lídia
Grothe, Michel J.
Carmona-Iragui, Maria
Videla, Laura
Benejam, Bessy
Arranz, Javier
Padilla, Concepción
Valldeneu, Sílvia
Barroeta, Isabel
Altuna, Miren
Fernández, Susana
Ribas, Laia
Valle-Tamayo, Natalia
Alcolea, Daniel
González-Ortiz, Sofía
Bargalló, Núria
Zetterberg, Henrik
Blennow, Kaj
Blesa, Rafael
Wisniewski, Thomas
Busciglio, Jorge
Cuello, A. Claudio
Lleó, Alberto
Fortea, Juan
author Aranha, Mateus Rozalem
author_facet Aranha, Mateus Rozalem
Iulita, Maria Florencia
Montal, Victor
Pegueroles, Jordi
Bejanin, Alexandre
Vaqué-Alcázar, Lídia
Grothe, Michel J.
Carmona-Iragui, Maria
Videla, Laura
Benejam, Bessy
Arranz, Javier
Padilla, Concepción
Valldeneu, Sílvia
Barroeta, Isabel
Altuna, Miren
Fernández, Susana
Ribas, Laia
Valle-Tamayo, Natalia
Alcolea, Daniel
González-Ortiz, Sofía
Bargalló, Núria
Zetterberg, Henrik
Blennow, Kaj
Blesa, Rafael
Wisniewski, Thomas
Busciglio, Jorge
Cuello, A. Claudio
Lleó, Alberto
Fortea, Juan
author_role author
author2 Iulita, Maria Florencia
Montal, Victor
Pegueroles, Jordi
Bejanin, Alexandre
Vaqué-Alcázar, Lídia
Grothe, Michel J.
Carmona-Iragui, Maria
Videla, Laura
Benejam, Bessy
Arranz, Javier
Padilla, Concepción
Valldeneu, Sílvia
Barroeta, Isabel
Altuna, Miren
Fernández, Susana
Ribas, Laia
Valle-Tamayo, Natalia
Alcolea, Daniel
González-Ortiz, Sofía
Bargalló, Núria
Zetterberg, Henrik
Blennow, Kaj
Blesa, Rafael
Wisniewski, Thomas
Busciglio, Jorge
Cuello, A. Claudio
Lleó, Alberto
Fortea, Juan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)
National Institutes of Health (US)
Generalitat de Catalunya
Fundación Tatiana Pérez de Guzmán el Bueno
European Commission
Alzheimer's Association
Societat Catalana de Neurologia
Swedish Research Council
European Research Council
Alzheimer Drug Discovery Foundation
Olav Thon Foundation
The Erling-Persson Family Foundation
Gamla Tjänarinnor Foundation
Dementia Research Institute (UK)
Hjärnfonden
Government of Sweden
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Alzheimer's disease
Basal forebrain
Biomarkers
Cholinergic
Down syndrome
Magnetic resonance imaging
Neuroimaging
Volumetry
topic Alzheimer's disease
Basal forebrain
Biomarkers
Cholinergic
Down syndrome
Magnetic resonance imaging
Neuroimaging
Volumetry
description [Background] Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/353534
url http://hdl.handle.net/10261/353534
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1002/alz.12999
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dc.publisher.none.fl_str_mv Alzheimer’s Association
publisher.none.fl_str_mv Alzheimer’s Association
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
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instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndromeAranha, Mateus RozalemIulita, Maria FlorenciaMontal, VictorPegueroles, JordiBejanin, AlexandreVaqué-Alcázar, LídiaGrothe, Michel J.Carmona-Iragui, MariaVidela, LauraBenejam, BessyArranz, JavierPadilla, ConcepciónValldeneu, SílviaBarroeta, IsabelAltuna, MirenFernández, SusanaRibas, LaiaValle-Tamayo, NataliaAlcolea, DanielGonzález-Ortiz, SofíaBargalló, NúriaZetterberg, HenrikBlennow, KajBlesa, RafaelWisniewski, ThomasBusciglio, JorgeCuello, A. ClaudioLleó, AlbertoFortea, JuanAlzheimer's diseaseBasal forebrainBiomarkersCholinergicDown syndromeMagnetic resonance imagingNeuroimagingVolumetry[Background] Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS.[Methods] We included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T-weighted magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid/tau/neurodegeneration biomarkers, and hippocampal volume.[Results] In DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance.[Discussion] BF atrophy is a potentially valuable neuroimaging biomarker of AD-related cholinergic neurodegeneration in DS.This study was supported by the Fondo de Investigaciones Sanitario, Carlos III Health Institute (PI20/01473 to JF, PI13/01532, PI16/01825 to RB, PI18/00335 to MCI, PI18/00435 to DA, PI14/1561, PI20/01330 to AL, PI20/00613 to MJG) and the CIBERNED Program 1. This work was also supported by the National Institutes of Health (NIH) grants (1R01AG056850-01A1; 3RF1AG056850-01S1; AG056850, R21AG056974, and R01AG061566 to JF; P30AG066512 and P01AG060882 to TW), Departament de Salut de la Generalitat de Catalunya, Fundación Tatiana Pérez de Guzmán el Bueno (IIBSP-DOW-2020-151 to JF), and the European Union's Horizon 2020, ‘MES-CoBraD’ (H2020-SC1-BHC-2018-2020 / GA 965422 to JF). MRA acknowledges support from the Alzheimer's Association Research Fellowship to Promote Diversity (AARF-D) Program (AARFD-21-852492). MFI acknowledges support from the Jérôme Lejeune postdoctoral award and pilot grant (#1941). AB acknowledges support from a Miguel Servet grant (CP20/00038) from the Carlos III Health Institute. MJG acknowledges support from a Miguel Servet grant (CP19/00031) from the Carlos III Health Institute. MCI acknowledges support from the Alzheimer's Association and Global Brain Health Institute (GBHI_ALZ-18-543740), the Jérôme Lejeune Foundation (#1913 Cycle 2019B), and the Societat Catalana de Neurologia (Premi Beca Fundació SCN 2020). LVA was supported by Margarita Salas junior postdoctoral fellowship (UNI/551/2021, NextGenerationUE). VM and NVT acknowledge support from predoctoral grants from the Carlos III Health Institute (FI18/00275 to VM and FI22/00077 to NVT). MA and JA were supported by the Río Hortega Fellowship from Carlos III Health Institute (CM19/00066 to MA and CM21/00243 to JA). CP acknowledges support from a Sara Borrell Fellowship (CP20/00133) from the Carlos III Health Institute. HZ is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2018-02532), the European Research Council (#681712 and #101053962), Swedish State Support for Clinical Research (#ALFGBG-71320), the Alzheimer Drug Discovery Foundation (ADDF), USA (#201809-2016862), the AD Strategic Fund and the Alzheimer's Association (#ADSF-21-831376-C, #ADSF-21-831381-C and #ADSF-21-831377-C), the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen för Gamla Tjänarinnor, Hjärnfonden, Sweden (#FO2022-0270), the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860197 (MIRIADE), the European Union Joint Programme – Neurodegenerative Disease Research (JPND2021-00694), and the UK Dementia Research Institute at UCL (UKDRI-1003). KB is supported by the Swedish Research Council (#2017-00915), the Swedish Alzheimer Foundation (#AF-930351, #AF-939721 and #AF-968270), Hjärnfonden, Sweden (#FO2017-0243 and #ALZ2022-0006), the Swedish state under the agreement between the Swedish government and the County Councils, the ALF-agreement (#ALFGBG-715986 and #ALFGBG-965240), and the Alzheimer's Association 2021 Zenith Award (ZEN-21-848495).Peer reviewedAlzheimer’s AssociationInstituto de Salud Carlos IIICentro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)National Institutes of Health (US)Generalitat de CatalunyaFundación Tatiana Pérez de Guzmán el BuenoEuropean CommissionAlzheimer's AssociationSocietat Catalana de NeurologiaSwedish Research CouncilEuropean Research CouncilAlzheimer Drug Discovery FoundationOlav Thon FoundationThe Erling-Persson Family FoundationGamla Tjänarinnor FoundationDementia Research Institute (UK)HjärnfondenGovernment of SwedenConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/353534reponame:DIGITAL.CSIC. 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