Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh

Excess weight, smoking and risky drinking are preventable risk factors for colorectal cancer (CRC). However, several studies have reported a protective association between aspirin and the risk of CRC. This article looks deeper into the relationships between risk factors and aspirin use with the risk...

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Autores: Florensa Cazorla, Dídac, Mateo Fornés, Jordi, Solsona Tehàs, Francesc, Galván, Leonardo, Mesas, Miquel, Piñol, Ramon, Espinosa-Leal, Leonardo, Godoy i García, Pere
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/463146
Acceso en línea:https://doi.org/10.3390/ijerph20054104
https://hdl.handle.net/10459.1/463146
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Aspirin use
Excess weight
Smoking
Risky drinking
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spelling Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess WeighFlorensa Cazorla, DídacMateo Fornés, JordiSolsona Tehàs, FrancescGalván, LeonardoMesas, MiquelPiñol, RamonEspinosa-Leal, LeonardoGodoy i García, PereColorectal cancerAspirin useExcess weightSmokingRisky drinkingExcess weight, smoking and risky drinking are preventable risk factors for colorectal cancer (CRC). However, several studies have reported a protective association between aspirin and the risk of CRC. This article looks deeper into the relationships between risk factors and aspirin use with the risk of developing CRC. We performed a retrospective cohort study of CRC risk factors and aspirin use in persons aged >50 years in Lleida province. The participants were inhabitants with some medication prescribed between 2007 and 2016 that were linked to the Population-Based Cancer Registry to detect CRC diagnosed between 2012 and 2016. Risk factors and aspirin use were studied using the adjusted HR (aHR) with 95% confidence intervals (CI) using a Cox proportional hazard model. We included 154,715 inhabitants of Lleida (Spain) aged >50 years. Of patients with CRC, 62% were male (HR = 1.8; 95% CI: 1.6–2.2), 39.5% were overweight (HR = 2.8; 95% CI: 2.3–3.4) and 47.3% were obese (HR = 3.0; 95% CI: 2.6–3.6). Cox regression showed an association between aspirin and CRC (aHR = 0.7; 95% CI: 0.6–0.8), confirming a protective effect against CRC and an association between the risk of CRC and excess weight (aHR = 1.4; 95% CI: 1.2–1.7), smoking (aHR = 1.4; 95% CI: 1.3–1.7) and risky drinking (aHR = 1.6; 95% CI: 1.2–2.0). Our results show that aspirin use decreased the risk of CRC and corroborate the relationship between overweight, smoking and risky drinking and the risk of CRC.his work was supported by contract 2019-DI-43 of the Industrial Doctorate Program of the Government of Catalonia. Project PID2020-113614RB-C22 was funded by the Spanish Ministry of Science and Innovation. Some authors are members of the 2014-SGR163 research group, funded by the Generalitat de Catalunya.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/ijerph20054104https://hdl.handle.net/10459.1/463146reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113614RB-C22Reproducció del document publicat a https://doi.org/10.3390/ijerph20054104International Journal of Environmental Research and Public Health, 2023, vol. 20, núm. 5, 4104cc-by (c) Florensa et al., 2023Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/4631462026-05-29T05:05:01Z
dc.title.none.fl_str_mv Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
title Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
spellingShingle Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
Florensa Cazorla, Dídac
Colorectal cancer
Aspirin use
Excess weight
Smoking
Risky drinking
title_short Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
title_full Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
title_fullStr Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
title_full_unstemmed Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
title_sort Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
dc.creator.none.fl_str_mv Florensa Cazorla, Dídac
Mateo Fornés, Jordi
Solsona Tehàs, Francesc
Galván, Leonardo
Mesas, Miquel
Piñol, Ramon
Espinosa-Leal, Leonardo
Godoy i García, Pere
author Florensa Cazorla, Dídac
author_facet Florensa Cazorla, Dídac
Mateo Fornés, Jordi
Solsona Tehàs, Francesc
Galván, Leonardo
Mesas, Miquel
Piñol, Ramon
Espinosa-Leal, Leonardo
Godoy i García, Pere
author_role author
author2 Mateo Fornés, Jordi
Solsona Tehàs, Francesc
Galván, Leonardo
Mesas, Miquel
Piñol, Ramon
Espinosa-Leal, Leonardo
Godoy i García, Pere
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Colorectal cancer
Aspirin use
Excess weight
Smoking
Risky drinking
topic Colorectal cancer
Aspirin use
Excess weight
Smoking
Risky drinking
description Excess weight, smoking and risky drinking are preventable risk factors for colorectal cancer (CRC). However, several studies have reported a protective association between aspirin and the risk of CRC. This article looks deeper into the relationships between risk factors and aspirin use with the risk of developing CRC. We performed a retrospective cohort study of CRC risk factors and aspirin use in persons aged >50 years in Lleida province. The participants were inhabitants with some medication prescribed between 2007 and 2016 that were linked to the Population-Based Cancer Registry to detect CRC diagnosed between 2012 and 2016. Risk factors and aspirin use were studied using the adjusted HR (aHR) with 95% confidence intervals (CI) using a Cox proportional hazard model. We included 154,715 inhabitants of Lleida (Spain) aged >50 years. Of patients with CRC, 62% were male (HR = 1.8; 95% CI: 1.6–2.2), 39.5% were overweight (HR = 2.8; 95% CI: 2.3–3.4) and 47.3% were obese (HR = 3.0; 95% CI: 2.6–3.6). Cox regression showed an association between aspirin and CRC (aHR = 0.7; 95% CI: 0.6–0.8), confirming a protective effect against CRC and an association between the risk of CRC and excess weight (aHR = 1.4; 95% CI: 1.2–1.7), smoking (aHR = 1.4; 95% CI: 1.3–1.7) and risky drinking (aHR = 1.6; 95% CI: 1.2–2.0). Our results show that aspirin use decreased the risk of CRC and corroborate the relationship between overweight, smoking and risky drinking and the risk of CRC.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/ijerph20054104
https://hdl.handle.net/10459.1/463146
url https://doi.org/10.3390/ijerph20054104
https://hdl.handle.net/10459.1/463146
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113614RB-C22
Reproducció del document publicat a https://doi.org/10.3390/ijerph20054104
International Journal of Environmental Research and Public Health, 2023, vol. 20, núm. 5, 4104
dc.rights.none.fl_str_mv cc-by (c) Florensa et al., 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Florensa et al., 2023
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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