Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain

Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas dia...

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Autores: Román, Marta, Caicoya, Martin, Espinàs, Josep Alfons, Sala i Serra, Maria, Torá Rocamora, Isabel, 1979-, Quinta, Maria J., Vernet-Tomás, Maria, Saladié, Francina, Romero, Anabel, Sánchez, Mar, Baré, Marisa, Vidal, Carmen, Servitja Tormo, Sonia, Natal, Carmen, Corominas Torres, Josep Maria, Ferrer, Joana, Rodríguez Arana, Ana Maria, Castells, Xavier, BELE Study Group
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/36493
Acceso en línea:http://hdl.handle.net/10230/36493
http://dx.doi.org/10.1111/tbj.13003
Access Level:acceso abierto
Palabra clave:Mama -- Malalties
Mama -- Càncer
Benign breast disease
Breast neoplasm
Prognostic factors
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spelling Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in SpainRomán, MartaCaicoya, MartinEspinàs, Josep AlfonsSala i Serra, MariaTorá Rocamora, Isabel, 1979-Quinta, Maria J.Vernet-Tomás, MariaSaladié, FrancinaRomero, AnabelSánchez, MarBaré, MarisaVidal, CarmenServitja Tormo, SoniaNatal, CarmenCorominas Torres, Josep MariaFerrer, JoanaRodríguez Arana, Ana MariaCastells, XavierBELE Study GroupMama -- MalaltiesMama -- CàncerBenign breast diseaseBreast neoplasmPrognostic factorsWomen with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.Wiley-Blackwell20192018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/36493http://dx.doi.org/10.1111/tbj.13003reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésThe Breast Journal. 2018 Jul;24(4):509-18This is the pre-peer reviewed version of the following article: Román M, Caicoya M, Espinàs J, Sala M, Torá-Rocamora I, Quinta MJ. et al. Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain. Breast J. 2018 Jul;24(4):509-518, which has been published in final form at http://dx.doi.org/10.1111/tbj.13003. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/364932026-05-29T05:05:01Z
dc.title.none.fl_str_mv Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
title Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
spellingShingle Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
Román, Marta
Mama -- Malalties
Mama -- Càncer
Benign breast disease
Breast neoplasm
Prognostic factors
title_short Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
title_full Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
title_fullStr Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
title_full_unstemmed Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
title_sort Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
dc.creator.none.fl_str_mv Román, Marta
Caicoya, Martin
Espinàs, Josep Alfons
Sala i Serra, Maria
Torá Rocamora, Isabel, 1979-
Quinta, Maria J.
Vernet-Tomás, Maria
Saladié, Francina
Romero, Anabel
Sánchez, Mar
Baré, Marisa
Vidal, Carmen
Servitja Tormo, Sonia
Natal, Carmen
Corominas Torres, Josep Maria
Ferrer, Joana
Rodríguez Arana, Ana Maria
Castells, Xavier
BELE Study Group
author Román, Marta
author_facet Román, Marta
Caicoya, Martin
Espinàs, Josep Alfons
Sala i Serra, Maria
Torá Rocamora, Isabel, 1979-
Quinta, Maria J.
Vernet-Tomás, Maria
Saladié, Francina
Romero, Anabel
Sánchez, Mar
Baré, Marisa
Vidal, Carmen
Servitja Tormo, Sonia
Natal, Carmen
Corominas Torres, Josep Maria
Ferrer, Joana
Rodríguez Arana, Ana Maria
Castells, Xavier
BELE Study Group
author_role author
author2 Caicoya, Martin
Espinàs, Josep Alfons
Sala i Serra, Maria
Torá Rocamora, Isabel, 1979-
Quinta, Maria J.
Vernet-Tomás, Maria
Saladié, Francina
Romero, Anabel
Sánchez, Mar
Baré, Marisa
Vidal, Carmen
Servitja Tormo, Sonia
Natal, Carmen
Corominas Torres, Josep Maria
Ferrer, Joana
Rodríguez Arana, Ana Maria
Castells, Xavier
BELE Study Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mama -- Malalties
Mama -- Càncer
Benign breast disease
Breast neoplasm
Prognostic factors
topic Mama -- Malalties
Mama -- Càncer
Benign breast disease
Breast neoplasm
Prognostic factors
description Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/36493
http://dx.doi.org/10.1111/tbj.13003
url http://hdl.handle.net/10230/36493
http://dx.doi.org/10.1111/tbj.13003
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The Breast Journal. 2018 Jul;24(4):509-18
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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