Osteosarcoma: correlation between radiological and histological changes after intra-arterial chemotherapy

The statistical correlation between three different radiological methods (conventional radiography, computed tomography and angiography) and tumor necrosis (TN) of the resected specimen have been studied in a series of 31 patients diagnosed with osteosarcoma (OS). They were treated with a multidisci...

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Detalles Bibliográficos
Autores: Bilbao, J.I. (José I.)|||/items/bd708ce9-03bf-41e5-96f2-0d6ce8b6fe88, Martin-Algarra, S. (Salvador)|||/items/2fba8e8b-e087-4ab0-82e3-a4d157f1e0cc, Martinez-de-Negri, J. (J.)|||/items/44c5ab76-5dd6-4b21-ae91-a30c340af1a0, Lecumberri, F. (F.)|||/items/726592a1-73ab-431c-b151-dc5aad3681ec, Longo, J. (J.)|||/items/39c572a3-2a4b-411b-b30e-3a2232147064, Sierrasesumaga, L. (Luis)|||/items/64d1f030-95e5-4055-a33a-920166ac53a3, Cañadell, J.M. (J. M.)|||/items/2becc2e2-213a-4695-91cf-07a6340692c8
Tipo de recurso: artículo
Fecha de publicación:1990
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/23153
Acceso en línea:https://hdl.handle.net/10171/23153
Access Level:acceso abierto
Palabra clave:Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Bone Neoplasms/drug therapy/pathology/radiography
Extremities/radiography
Descripción
Sumario:The statistical correlation between three different radiological methods (conventional radiography, computed tomography and angiography) and tumor necrosis (TN) of the resected specimen have been studied in a series of 31 patients diagnosed with osteosarcoma (OS). They were treated with a multidisciplinary approach including intraarterial and intravenous chemotherapy followed by limb salvage procedures, plus intraoperative radiotherapy and adjuvant chemotherapy. A clear statistical correlation has been obtained between TN and angiography (p = 0.02) and between TN and two specific radiological signs: 'tumoral stain and neovascularity' (p = 0.02) and 'peritumoral fat planes' (p = 0.05). Conventional radiography, computed tomography and other radiological signs studied (nutrient vessel, soft tissue mass and central peripheral calcifications) did not show any significant correlation with TN. These results seem to suggest that angiography is a method to evaluate TN preoperatively and also to define the efficacy of neoadjuvant chemotherapy in OS.

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