Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients

BACKGROUND There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and...

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Autores: Milman A, Gourraud JB, Andorin A, Postema PG, Sacher F, Mabo P, Conte G, Giustetto C, Sarquella-Brugada G, Hochstadt A, Kim SH, Juang JJ, Maeda S, Takahashi Y, Kamakura T, Aiba T, Leshem E, Michowitz Y, Rahkovich M, Mizusawa Y, Arbelo E, Huang Z, Denjoy I, Wijeyeratne YD, Napolitano C, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Tfelt-Hansen J, Priori SG, Takagi M, Veltmann C, Delise P, Corrado D, Behr ER, Gaita F, Yan GX, Brugada J, Leenhardt A, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p14546
Acesso em linha:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14546
Access Level:acceso abierto
Palavra-chave:Brugada ECG
Ethnicity
Implantable cardioverter-de-fibrillator Ethnicity
SCN5A mutation
Sudden cardiac death
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spelling Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patientsMilman AGourraud JBAndorin APostema PGSacher FMabo PConte GGiustetto CSarquella-Brugada GHochstadt AKim SHJuang JJMaeda STakahashi YKamakura TAiba TLeshem EMichowitz YRahkovich MMizusawa YArbelo EHuang ZDenjoy IWijeyeratne YDNapolitano CBrugada RCasado-Arroyo RChampagne JCalo LTfelt-Hansen JPriori SGTakagi MVeltmann CDelise PCorrado DBehr ERGaita FYan GXBrugada JLeenhardt AWilde AAMBrugada PKusano KFHirao KNam GBProbst VBelhassen BBrugada ECGEthnicityImplantable cardioverter-de-fibrillator EthnicitySCN5A mutationSudden cardiac deathBACKGROUND There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients with BrS with their first AE. METHODS The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 patients with BrS including 619 males (91.3%) and 59 females (8.7%) aged 0.27-84 years (mean age 42.5 +/- 14.1 years) at the time of AE occurrence. RESULTS After excluding pediatric patients, it was found that females were older than males (49.5 +/- 14.4 years vs 43 +/- 12.7 years, respectively; P = .001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, the male to female ratio for AEs was approximate to 9-fold higher than that in White. Spontaneous type 1 BrS ECG was associated with an earlier onset of AEs in pediatric females. A similar prevalence (approximate to 65%) of spontaneous type 1 BrS ECG was present in males and females above the age of 60 years. Females less frequently showed spontaneous type 1 BrS ECG (41% vs 69%; P < .001) or arrhythmia inducibility at electrophysiology study (36% vs 66%; P < .001). An SCN5A mutation was more frequently found in females (48% vs 28% in males; P = .007). CONCLUSION This study confirms that female patients with BrS are much rarer, display less type 1 Brugada ECG, and exhibit lower inducibility rates than domales. It shows for the first time that female patients with BrS with AE have higher SCN5A mutation rates as well as the relationship between gender vs age at the onset of AEs and ethnicity. (C) 2018 Heart Rhythm Society. All rights reserved.ELSEVIER SCIENCE INC2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14546HEART RHYTHMISSN: 15475271ISSNe: 15563871reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p145462026-05-27T12:37:41Z
dc.title.none.fl_str_mv Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
title Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
spellingShingle Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
Milman A
Brugada ECG
Ethnicity
Implantable cardioverter-de-fibrillator Ethnicity
SCN5A mutation
Sudden cardiac death
title_short Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
title_full Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
title_fullStr Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
title_full_unstemmed Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
title_sort Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
dc.creator.none.fl_str_mv Milman A
Gourraud JB
Andorin A
Postema PG
Sacher F
Mabo P
Conte G
Giustetto C
Sarquella-Brugada G
Hochstadt A
Kim SH
Juang JJ
Maeda S
Takahashi Y
Kamakura T
Aiba T
Leshem E
Michowitz Y
Rahkovich M
Mizusawa Y
Arbelo E
Huang Z
Denjoy I
Wijeyeratne YD
Napolitano C
Brugada R
Casado-Arroyo R
Champagne J
Calo L
Tfelt-Hansen J
Priori SG
Takagi M
Veltmann C
Delise P
Corrado D
Behr ER
Gaita F
Yan GX
Brugada J
Leenhardt A
Wilde AAM
Brugada P
Kusano KF
Hirao K
Nam GB
Probst V
Belhassen B
author Milman A
author_facet Milman A
Gourraud JB
Andorin A
Postema PG
Sacher F
Mabo P
Conte G
Giustetto C
Sarquella-Brugada G
Hochstadt A
Kim SH
Juang JJ
Maeda S
Takahashi Y
Kamakura T
Aiba T
Leshem E
Michowitz Y
Rahkovich M
Mizusawa Y
Arbelo E
Huang Z
Denjoy I
Wijeyeratne YD
Napolitano C
Brugada R
Casado-Arroyo R
Champagne J
Calo L
Tfelt-Hansen J
Priori SG
Takagi M
Veltmann C
Delise P
Corrado D
Behr ER
Gaita F
Yan GX
Brugada J
Leenhardt A
Wilde AAM
Brugada P
Kusano KF
Hirao K
Nam GB
Probst V
Belhassen B
author_role author
author2 Gourraud JB
Andorin A
Postema PG
Sacher F
Mabo P
Conte G
Giustetto C
Sarquella-Brugada G
Hochstadt A
Kim SH
Juang JJ
Maeda S
Takahashi Y
Kamakura T
Aiba T
Leshem E
Michowitz Y
Rahkovich M
Mizusawa Y
Arbelo E
Huang Z
Denjoy I
Wijeyeratne YD
Napolitano C
Brugada R
Casado-Arroyo R
Champagne J
Calo L
Tfelt-Hansen J
Priori SG
Takagi M
Veltmann C
Delise P
Corrado D
Behr ER
Gaita F
Yan GX
Brugada J
Leenhardt A
Wilde AAM
Brugada P
Kusano KF
Hirao K
Nam GB
Probst V
Belhassen B
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Brugada ECG
Ethnicity
Implantable cardioverter-de-fibrillator Ethnicity
SCN5A mutation
Sudden cardiac death
topic Brugada ECG
Ethnicity
Implantable cardioverter-de-fibrillator Ethnicity
SCN5A mutation
Sudden cardiac death
description BACKGROUND There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients with BrS with their first AE. METHODS The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 patients with BrS including 619 males (91.3%) and 59 females (8.7%) aged 0.27-84 years (mean age 42.5 +/- 14.1 years) at the time of AE occurrence. RESULTS After excluding pediatric patients, it was found that females were older than males (49.5 +/- 14.4 years vs 43 +/- 12.7 years, respectively; P = .001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, the male to female ratio for AEs was approximate to 9-fold higher than that in White. Spontaneous type 1 BrS ECG was associated with an earlier onset of AEs in pediatric females. A similar prevalence (approximate to 65%) of spontaneous type 1 BrS ECG was present in males and females above the age of 60 years. Females less frequently showed spontaneous type 1 BrS ECG (41% vs 69%; P < .001) or arrhythmia inducibility at electrophysiology study (36% vs 66%; P < .001). An SCN5A mutation was more frequently found in females (48% vs 28% in males; P = .007). CONCLUSION This study confirms that female patients with BrS are much rarer, display less type 1 Brugada ECG, and exhibit lower inducibility rates than domales. It shows for the first time that female patients with BrS with AE have higher SCN5A mutation rates as well as the relationship between gender vs age at the onset of AEs and ethnicity. (C) 2018 Heart Rhythm Society. All rights reserved.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14546
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14546
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv HEART RHYTHM
ISSN: 15475271
ISSNe: 15563871
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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