Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment

Objectives Thrombocytosis is more prevalent in pediatric than in adult patients and is associated with complications or worsened outcomes after vascular events. This study aimed to determine the prevalence of thrombocytosis in very preterm infants who had not received human recombinant erythropoieti...

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Autores: Del Rey Hurtado de Mendoza B, Esponera CB, Izquierdo Renau M, Iglesias Platas I
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p15862
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15862
Access Level:acceso abierto
Palabra clave:Thrombocytosis
very preterm infant
retinopathy of prematurity
blood count
human recombinant erythropoietin
platelet
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spelling Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatmentDel Rey Hurtado de Mendoza BEsponera CBIzquierdo Renau MIglesias Platas IThrombocytosisvery preterm infantretinopathy of prematurityblood counthuman recombinant erythropoietinplateletObjectives Thrombocytosis is more prevalent in pediatric than in adult patients and is associated with complications or worsened outcomes after vascular events. This study aimed to determine the prevalence of thrombocytosis in very preterm infants who had not received human recombinant erythropoietin treatment (rHuEPO) and its relationship with other hematological parameters and clinical complications. Methods We performed a retrospective study of hematological and clinical data of very preterm infants who were admitted to our unit in their first 48 hours of life and stayed for longer than 1 week. Results Thrombocytosis was prevalent (32.6% of patients) in very preterm infants (<= 32 weeks of gestational age, n = 193) who had not received rHuEPO. The platelet count was positively correlated with calendar age. Infants with thrombocytosis were significantly more premature (28.0 +/- 2.1 versus 29.6 +/- 2.2 weeks) and had a lower birth weight (1036 +/- 304 versus 1303 +/- 304) than those without thrombocytosis. Thrombocytosis was associated with retinopathy of prematurity after adjusting for gestational age and comorbidities, but not with other prematurity-associated complications. Conclusions Late asymptomatic thrombocytosis is common in very preterm infants at approximately 1 month of postnatal age and it may be associated with retinopathy of prematurity.SAGE PUBLICATIONS LTD2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15862JOURNAL OF INTERNATIONAL MEDICAL RESEARCHISSN: 03000605ISSNe: 14732300reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p158622026-05-27T12:37:41Z
dc.title.none.fl_str_mv Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment
title Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment
spellingShingle Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment
Del Rey Hurtado de Mendoza B
Thrombocytosis
very preterm infant
retinopathy of prematurity
blood count
human recombinant erythropoietin
platelet
title_short Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment
title_full Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment
title_fullStr Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment
title_full_unstemmed Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment
title_sort Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment
dc.creator.none.fl_str_mv Del Rey Hurtado de Mendoza B
Esponera CB
Izquierdo Renau M
Iglesias Platas I
author Del Rey Hurtado de Mendoza B
author_facet Del Rey Hurtado de Mendoza B
Esponera CB
Izquierdo Renau M
Iglesias Platas I
author_role author
author2 Esponera CB
Izquierdo Renau M
Iglesias Platas I
author2_role author
author
author
dc.subject.none.fl_str_mv Thrombocytosis
very preterm infant
retinopathy of prematurity
blood count
human recombinant erythropoietin
platelet
topic Thrombocytosis
very preterm infant
retinopathy of prematurity
blood count
human recombinant erythropoietin
platelet
description Objectives Thrombocytosis is more prevalent in pediatric than in adult patients and is associated with complications or worsened outcomes after vascular events. This study aimed to determine the prevalence of thrombocytosis in very preterm infants who had not received human recombinant erythropoietin treatment (rHuEPO) and its relationship with other hematological parameters and clinical complications. Methods We performed a retrospective study of hematological and clinical data of very preterm infants who were admitted to our unit in their first 48 hours of life and stayed for longer than 1 week. Results Thrombocytosis was prevalent (32.6% of patients) in very preterm infants (<= 32 weeks of gestational age, n = 193) who had not received rHuEPO. The platelet count was positively correlated with calendar age. Infants with thrombocytosis were significantly more premature (28.0 +/- 2.1 versus 29.6 +/- 2.2 weeks) and had a lower birth weight (1036 +/- 304 versus 1303 +/- 304) than those without thrombocytosis. Thrombocytosis was associated with retinopathy of prematurity after adjusting for gestational age and comorbidities, but not with other prematurity-associated complications. Conclusions Late asymptomatic thrombocytosis is common in very preterm infants at approximately 1 month of postnatal age and it may be associated with retinopathy of prematurity.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15862
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15862
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
dc.source.none.fl_str_mv JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
ISSN: 03000605
ISSNe: 14732300
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
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collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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