Liver transplantation in metastatic colorectal cancer

Colorectal cancer (CRC) is a prevalent disease worldwide, with more than 50% of patients developing metastases to the liver. Five-year overall survival remains modest among patients with metastatic CRC (mCRC) treated with conventional therapies however, liver transplantation in a highly selected pop...

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Autores: Ros-Montañá, Francisco Javier|||0000-0002-8137-5415, Salvà, Francesc|||0000-0001-9240-4907, Dopazo, Cristina|||0000-0001-6274-5911, López, Daniel, Saoudi, Nadia, Baraibar, Iosune|||0000-0002-3500-9641, Charco, Ramon|||0000-0001-9709-6288, Tabernero, Josep|||0000-0002-2495-8139, Elez, Elena|||0000-0002-4653-6324
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:281642
Acceso en línea:https://ddd.uab.cat/record/281642
https://dx.doi.org/urn:doi:10.1038/s41416-023-02213-1
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Surgical oncology
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spelling Liver transplantation in metastatic colorectal cancerare we ready for it?Ros-Montañá, Francisco Javier|||0000-0002-8137-5415Salvà, Francesc|||0000-0001-9240-4907Dopazo, Cristina|||0000-0001-6274-5911López, DanielSaoudi, NadiaBaraibar, Iosune|||0000-0002-3500-9641Charco, Ramon|||0000-0001-9709-6288Tabernero, Josep|||0000-0002-2495-8139Elez, Elena|||0000-0002-4653-6324Colorectal cancerSurgical oncologyColorectal cancer (CRC) is a prevalent disease worldwide, with more than 50% of patients developing metastases to the liver. Five-year overall survival remains modest among patients with metastatic CRC (mCRC) treated with conventional therapies however, liver transplantation in a highly selected population can improve clinical outcomes with an impressive 5-year overall survival of 83%. Despite liver transplantation appearing to be a promising therapeutical option for well-selected patients with mCRC with the liver-limited disease, these data come from small monocentric trials which included a heterogeneous population. Currently, several clinical trials are evaluating liver transplantation in this scenario, aiming for a more accurate patient selection by integrating liquid biopsy, tissue profiling, and nuclear medicine to the already known clinical biomarkers that eventually may lead to a survival improvement. In this paper, the clinical outcomes and inclusion criteria from the most relevant clinical trials and clinical series involving liver transplantation in patients with liver-limited disease colorectal cancer are reviewed as well as the trials currently recruiting.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/281642https://dx.doi.org/urn:doi:10.1038/s41416-023-02213-1reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2816422026-06-06T12:50:31Z
dc.title.none.fl_str_mv Liver transplantation in metastatic colorectal cancer
are we ready for it?
title Liver transplantation in metastatic colorectal cancer
spellingShingle Liver transplantation in metastatic colorectal cancer
Ros-Montañá, Francisco Javier|||0000-0002-8137-5415
Colorectal cancer
Surgical oncology
title_short Liver transplantation in metastatic colorectal cancer
title_full Liver transplantation in metastatic colorectal cancer
title_fullStr Liver transplantation in metastatic colorectal cancer
title_full_unstemmed Liver transplantation in metastatic colorectal cancer
title_sort Liver transplantation in metastatic colorectal cancer
dc.creator.none.fl_str_mv Ros-Montañá, Francisco Javier|||0000-0002-8137-5415
Salvà, Francesc|||0000-0001-9240-4907
Dopazo, Cristina|||0000-0001-6274-5911
López, Daniel
Saoudi, Nadia
Baraibar, Iosune|||0000-0002-3500-9641
Charco, Ramon|||0000-0001-9709-6288
Tabernero, Josep|||0000-0002-2495-8139
Elez, Elena|||0000-0002-4653-6324
author Ros-Montañá, Francisco Javier|||0000-0002-8137-5415
author_facet Ros-Montañá, Francisco Javier|||0000-0002-8137-5415
Salvà, Francesc|||0000-0001-9240-4907
Dopazo, Cristina|||0000-0001-6274-5911
López, Daniel
Saoudi, Nadia
Baraibar, Iosune|||0000-0002-3500-9641
Charco, Ramon|||0000-0001-9709-6288
Tabernero, Josep|||0000-0002-2495-8139
Elez, Elena|||0000-0002-4653-6324
author_role author
author2 Salvà, Francesc|||0000-0001-9240-4907
Dopazo, Cristina|||0000-0001-6274-5911
López, Daniel
Saoudi, Nadia
Baraibar, Iosune|||0000-0002-3500-9641
Charco, Ramon|||0000-0001-9709-6288
Tabernero, Josep|||0000-0002-2495-8139
Elez, Elena|||0000-0002-4653-6324
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Colorectal cancer
Surgical oncology
topic Colorectal cancer
Surgical oncology
description Colorectal cancer (CRC) is a prevalent disease worldwide, with more than 50% of patients developing metastases to the liver. Five-year overall survival remains modest among patients with metastatic CRC (mCRC) treated with conventional therapies however, liver transplantation in a highly selected population can improve clinical outcomes with an impressive 5-year overall survival of 83%. Despite liver transplantation appearing to be a promising therapeutical option for well-selected patients with mCRC with the liver-limited disease, these data come from small monocentric trials which included a heterogeneous population. Currently, several clinical trials are evaluating liver transplantation in this scenario, aiming for a more accurate patient selection by integrating liquid biopsy, tissue profiling, and nuclear medicine to the already known clinical biomarkers that eventually may lead to a survival improvement. In this paper, the clinical outcomes and inclusion criteria from the most relevant clinical trials and clinical series involving liver transplantation in patients with liver-limited disease colorectal cancer are reviewed as well as the trials currently recruiting.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/281642
https://dx.doi.org/urn:doi:10.1038/s41416-023-02213-1
url https://ddd.uab.cat/record/281642
https://dx.doi.org/urn:doi:10.1038/s41416-023-02213-1
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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