Engineered graphene material improves the performance of intraneural peripheral nerve electrodes

Limb neuroprostheses aim to restore motor and sensory functions in amputated or severely nerve-injured patients. These devices use neural interfaces to record and stimulate nerve action potentials, creating a bidirectional connection with the nervous system. Most neural interfaces are based on stand...

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Autores: Rodríguez-Meana, Bruno, Valle, Jaume del, Viana, Damià, Walston, Steven T., Ria, Nicola, Masvidal Codina, Eduard, Garrido, Jose A., Navarro, Xavier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/375288
Acceso en línea:http://hdl.handle.net/10261/375288
Access Level:acceso abierto
Palabra clave:Foreign body reaction
Graphene
Intraneural electrode
Neuroprostheses
Recording
Stimulation
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dc.title.none.fl_str_mv Engineered graphene material improves the performance of intraneural peripheral nerve electrodes
title Engineered graphene material improves the performance of intraneural peripheral nerve electrodes
spellingShingle Engineered graphene material improves the performance of intraneural peripheral nerve electrodes
Rodríguez-Meana, Bruno
Foreign body reaction
Graphene
Intraneural electrode
Neuroprostheses
Recording
Stimulation
title_short Engineered graphene material improves the performance of intraneural peripheral nerve electrodes
title_full Engineered graphene material improves the performance of intraneural peripheral nerve electrodes
title_fullStr Engineered graphene material improves the performance of intraneural peripheral nerve electrodes
title_full_unstemmed Engineered graphene material improves the performance of intraneural peripheral nerve electrodes
title_sort Engineered graphene material improves the performance of intraneural peripheral nerve electrodes
dc.creator.none.fl_str_mv Rodríguez-Meana, Bruno
Valle, Jaume del
Viana, Damià
Walston, Steven T.
Ria, Nicola
Masvidal Codina, Eduard
Garrido, Jose A.
Navarro, Xavier
author Rodríguez-Meana, Bruno
author_facet Rodríguez-Meana, Bruno
Valle, Jaume del
Viana, Damià
Walston, Steven T.
Ria, Nicola
Masvidal Codina, Eduard
Garrido, Jose A.
Navarro, Xavier
author_role author
author2 Valle, Jaume del
Viana, Damià
Walston, Steven T.
Ria, Nicola
Masvidal Codina, Eduard
Garrido, Jose A.
Navarro, Xavier
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Instituto de Salud Carlos III
Generalitat de Catalunya
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Foreign body reaction
Graphene
Intraneural electrode
Neuroprostheses
Recording
Stimulation
topic Foreign body reaction
Graphene
Intraneural electrode
Neuroprostheses
Recording
Stimulation
description Limb neuroprostheses aim to restore motor and sensory functions in amputated or severely nerve-injured patients. These devices use neural interfaces to record and stimulate nerve action potentials, creating a bidirectional connection with the nervous system. Most neural interfaces are based on standard metal microelectrodes. In this work, a new generation of neural interfaces which replaces metals with engineered graphene, called EGNITE, is tested. In vitro and in vivo experiments are conducted to assess EGNITE biocompatibility. In vitro tests show that EGNITE does not impact cell viability. In vivo, no significant functional decrease or harmful effects are observed. Furthermore, the foreign body reaction to the intraneural implant is similar compared to other materials previously used in neural interfaces. Regarding functionality, EGNITE devices are able to stimulate nerve fascicles, during two months of implant, producing selective muscle activation with about three times less current compared to larger microelectrodes of standard materials. CNAP elicited by electrical stimuli and ENG evoked by mechanical stimuli are recorded with high resolution but are more affected by decreased functionality over time. This work constitutes further proof that graphene-derived materials, and specifically EGNITE, is a promising conductive material of neural electrodes for advanced neuroprostheses.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/375288
url http://hdl.handle.net/10261/375288
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The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1002/advs.202308689
https://doi.org/10.1002/advs.202308689
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dc.publisher.none.fl_str_mv Wiley-VCH
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spelling Engineered graphene material improves the performance of intraneural peripheral nerve electrodesRodríguez-Meana, BrunoValle, Jaume delViana, DamiàWalston, Steven T.Ria, NicolaMasvidal Codina, EduardGarrido, Jose A.Navarro, XavierForeign body reactionGrapheneIntraneural electrodeNeuroprosthesesRecordingStimulationLimb neuroprostheses aim to restore motor and sensory functions in amputated or severely nerve-injured patients. These devices use neural interfaces to record and stimulate nerve action potentials, creating a bidirectional connection with the nervous system. Most neural interfaces are based on standard metal microelectrodes. In this work, a new generation of neural interfaces which replaces metals with engineered graphene, called EGNITE, is tested. In vitro and in vivo experiments are conducted to assess EGNITE biocompatibility. In vitro tests show that EGNITE does not impact cell viability. In vivo, no significant functional decrease or harmful effects are observed. Furthermore, the foreign body reaction to the intraneural implant is similar compared to other materials previously used in neural interfaces. Regarding functionality, EGNITE devices are able to stimulate nerve fascicles, during two months of implant, producing selective muscle activation with about three times less current compared to larger microelectrodes of standard materials. CNAP elicited by electrical stimuli and ENG evoked by mechanical stimuli are recorded with high resolution but are more affected by decreased functionality over time. This work constitutes further proof that graphene-derived materials, and specifically EGNITE, is a promising conductive material of neural electrodes for advanced neuroprostheses.This research was funded by FLAG-ERA JTC 2017 project GRAFIN and FLAG-ERA JTC 2021 project RESCUEGRAPH, by the Agencia Estatal de Investigación of Spain projects PCI2018-093029 and PCI2021-122075; and by CIBERNED (grant CB06/05/1105) and TERAV (RD21/0017/0008) funds from the Instituto de Salud Carlos III of Spain, co-funded by European Union (NextGenerationEU, Recovery, Transformation and Resilience Plan). ICN2 is supported by the Severo Ochoa Centres of Excellence programme (Grant CEX2021-001214-S), funded by MCIN/AEI/10.13039.501100011033, and by the CERCA Programme of Generalitat de Catalunya; and Project PCI2021-122095-2A financed by MCIN/AEI/10.13039/501 100 011 033 and by the European Union NextGenerationEU/PRTR. The RT97 antibody was obtained from the Developmental Studies Hybridoma Bank, created by the NICHD of the NIH and maintained at the University of Iowa, Department of Biology. E.M.C. acknowledges grant FJC2021-046601-I funded by Agencia Estatal de Investigación of Spain and the European Union NextGenerationEU/PRTR. N.R. acknowledges AyudaPRE2020-093708 provided by MCIN/AEI/10.13039/501 100 011 033 and FSE invierte en tu futuro.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001214-S).Peer reviewedWiley-VCHEuropean CommissionMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Instituto de Salud Carlos IIIGeneralitat de CatalunyaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/375288reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001214-Sinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PCI2018-093029info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PCI2021-122075-2Ainfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PCI2021-122095-2Ainfo:eu-repo/grantAgreement/AEI//FJC2021-046601-Iinfo:eu-repo/grantAgreement/AEI//PRE2020-093708The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1002/advs.202308689https://doi.org/10.1002/advs.202308689Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3752882026-05-22T06:33:51Z
score 15,812429

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