Inhaled Loxapine for Agitation in Intoxicated Patients

Episodes of agitation are frequent in intoxicated patients who have a substance use disorder, a psychiatric disorder or both (dual diagnosis). For managing the agitation, it is necessary to act promptly in a safe environment and addressing any underlying etiology. Inhaled loxapine improves symptoms...

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Authors: Roncero, Carlos|||0000-0003-1421-7385, Ros-Cucurull, Elena, Palma-Álvarez, Raúl Felipe|||0000-0002-6428-9865, Abad, Alfonso Carlos|||0000-0001-5706-7693, Fadeuilhe, Christian|||0000-0001-5821-347X, Casas Brugué, Miquel|||0000-0003-3496-8522, Grau-López, Lara|||0000-0003-1297-1819
Format: article
Publication Date:2017
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:186355
Online Access:https://ddd.uab.cat/record/186355
https://dx.doi.org/urn:doi:10.1097/WNF.0000000000000252
Access Level:Open access
Keyword:Agitation
Inhaled loxapine
Emergency
Substance use disorders
Mental disorders
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spelling Inhaled Loxapine for Agitation in Intoxicated PatientsA Case SeriesRoncero, Carlos|||0000-0003-1421-7385Ros-Cucurull, ElenaPalma-Álvarez, Raúl Felipe|||0000-0002-6428-9865Abad, Alfonso Carlos|||0000-0001-5706-7693Fadeuilhe, Christian|||0000-0001-5821-347XCasas Brugué, Miquel|||0000-0003-3496-8522Grau-López, Lara|||0000-0003-1297-1819AgitationInhaled loxapineEmergencySubstance use disordersMental disordersEpisodes of agitation are frequent in intoxicated patients who have a substance use disorder, a psychiatric disorder or both (dual diagnosis). For managing the agitation, it is necessary to act promptly in a safe environment and addressing any underlying etiology. Inhaled loxapine improves symptoms of agitation in adults with psychiatric disorders (eg, schizophrenia) within 10 minutes of administration. Recently, some reports have documented the usefulness of loxapine in dual diagnoses patients with agitation. However, the efficacy of loxapine in intoxicated patients has not been deeply addressed. This report describes a case series of 12 patients (with addiction or dual disorder) who received inhaled loxapine for symptoms of psychomotor agitation during intoxication with different substances (eg, alcohol, cannabis, or cocaine) at 1 center in Spain. Data from 12 patients were reviewed, 5 patients were attended at the emergency room, 4 at the addiction and dual diagnosis unit, and 3 were treated during hospitalization for detoxification. All patients were under effects of substances. They had substance use disorder (including cannabis, cocaine, alcohol, hypnotics, and hallucinogens), and almost all (90%) presented 1 or more psychiatric disorders. One dose of inhaled loxapine was effective in 9 patients (75%), and in 3 patients, a second dose was required. Only mild dizziness was reported in 1 patient after the second dose. The acute agitation was effectively and quickly managed with inhaled loxapine in all intoxicated patients and enabled the appropriate clinical evaluation of the agitated state and the patient's management.Universitat Autònoma de Barcelona 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/186355https://dx.doi.org/urn:doi:10.1097/WNF.0000000000000252reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1863552026-06-06T12:50:31Z
dc.title.none.fl_str_mv Inhaled Loxapine for Agitation in Intoxicated Patients
A Case Series
title Inhaled Loxapine for Agitation in Intoxicated Patients
spellingShingle Inhaled Loxapine for Agitation in Intoxicated Patients
Roncero, Carlos|||0000-0003-1421-7385
Agitation
Inhaled loxapine
Emergency
Substance use disorders
Mental disorders
title_short Inhaled Loxapine for Agitation in Intoxicated Patients
title_full Inhaled Loxapine for Agitation in Intoxicated Patients
title_fullStr Inhaled Loxapine for Agitation in Intoxicated Patients
title_full_unstemmed Inhaled Loxapine for Agitation in Intoxicated Patients
title_sort Inhaled Loxapine for Agitation in Intoxicated Patients
dc.creator.none.fl_str_mv Roncero, Carlos|||0000-0003-1421-7385
Ros-Cucurull, Elena
Palma-Álvarez, Raúl Felipe|||0000-0002-6428-9865
Abad, Alfonso Carlos|||0000-0001-5706-7693
Fadeuilhe, Christian|||0000-0001-5821-347X
Casas Brugué, Miquel|||0000-0003-3496-8522
Grau-López, Lara|||0000-0003-1297-1819
author Roncero, Carlos|||0000-0003-1421-7385
author_facet Roncero, Carlos|||0000-0003-1421-7385
Ros-Cucurull, Elena
Palma-Álvarez, Raúl Felipe|||0000-0002-6428-9865
Abad, Alfonso Carlos|||0000-0001-5706-7693
Fadeuilhe, Christian|||0000-0001-5821-347X
Casas Brugué, Miquel|||0000-0003-3496-8522
Grau-López, Lara|||0000-0003-1297-1819
author_role author
author2 Ros-Cucurull, Elena
Palma-Álvarez, Raúl Felipe|||0000-0002-6428-9865
Abad, Alfonso Carlos|||0000-0001-5706-7693
Fadeuilhe, Christian|||0000-0001-5821-347X
Casas Brugué, Miquel|||0000-0003-3496-8522
Grau-López, Lara|||0000-0003-1297-1819
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Agitation
Inhaled loxapine
Emergency
Substance use disorders
Mental disorders
topic Agitation
Inhaled loxapine
Emergency
Substance use disorders
Mental disorders
description Episodes of agitation are frequent in intoxicated patients who have a substance use disorder, a psychiatric disorder or both (dual diagnosis). For managing the agitation, it is necessary to act promptly in a safe environment and addressing any underlying etiology. Inhaled loxapine improves symptoms of agitation in adults with psychiatric disorders (eg, schizophrenia) within 10 minutes of administration. Recently, some reports have documented the usefulness of loxapine in dual diagnoses patients with agitation. However, the efficacy of loxapine in intoxicated patients has not been deeply addressed. This report describes a case series of 12 patients (with addiction or dual disorder) who received inhaled loxapine for symptoms of psychomotor agitation during intoxication with different substances (eg, alcohol, cannabis, or cocaine) at 1 center in Spain. Data from 12 patients were reviewed, 5 patients were attended at the emergency room, 4 at the addiction and dual diagnosis unit, and 3 were treated during hospitalization for detoxification. All patients were under effects of substances. They had substance use disorder (including cannabis, cocaine, alcohol, hypnotics, and hallucinogens), and almost all (90%) presented 1 or more psychiatric disorders. One dose of inhaled loxapine was effective in 9 patients (75%), and in 3 patients, a second dose was required. Only mild dizziness was reported in 1 patient after the second dose. The acute agitation was effectively and quickly managed with inhaled loxapine in all intoxicated patients and enabled the appropriate clinical evaluation of the agitated state and the patient's management.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/186355
https://dx.doi.org/urn:doi:10.1097/WNF.0000000000000252
url https://ddd.uab.cat/record/186355
https://dx.doi.org/urn:doi:10.1097/WNF.0000000000000252
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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