Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance

The thalamocortical projections are part of the most important higher level processing connections in the vertebrates and follow a highly ordered pathway from their origin in the thalamus to the cerebral cortex. Their functional complexities are not only due to an extremely elaborate axon guidance p...

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Autores: Callejas-Marin, A, Moreno-Bravo, JA, Company, V, Madrigal, MP, Almagro-Garcia, F, Martinez, S, Puelles, E
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p8571
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones8571
Access Level:acceso abierto
Palabra clave:thalamocortical axons
guidance
Gli2
Slit1
Slit2
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spelling Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection GuidanceCallejas-Marin, AMoreno-Bravo, JACompany, VMadrigal, MPAlmagro-Garcia, FMartinez, SPuelles, Ethalamocortical axonsguidanceGli2Slit1Slit2The thalamocortical projections are part of the most important higher level processing connections in the vertebrates and follow a highly ordered pathway from their origin in the thalamus to the cerebral cortex. Their functional complexities are not only due to an extremely elaborate axon guidance process but also due to activity-dependent mechanisms. Gli2 is an intermediary transcription factor in the Sonic hedgehog (Shh) pathway. During neural early development, Shh has an important role in dorsoventral patterning, diencephalic anteroposterior patterning, and many later developmental processes, such as axon guidance and cell migration. Using a Gli2 knockout mouse line, we have studied the role of Shh signaling mediated by Gli2 in the development of the thalamocortical projections during embryonic development. In wild-type brains, we have described the normal trajectory of the thalamocortical axons into the context of the prosomeric model. Then, we have compared it with the altered thalamocortical axons course in Gli2 homozygous embryos. The thalamocortical axons followed different trajectories and were misdirected to other territories probably due to alterations in the Robo/Slit signaling mechanism. In conclusion, the alteration of Gli2-mediated Shh signaling produces an erroneous specification of several territories related with the thalamocortical axons. This is translated into a huge modification in the pathfinding signaling mechanisms needed for the correct wiring of the thalamocortical axons.FRONTIERS MEDIA SA2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones8571Frontiers in NeuroanatomyISSN: 16625129reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p85712026-06-12T10:20:37Z
dc.title.none.fl_str_mv Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
title Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
spellingShingle Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
Callejas-Marin, A
thalamocortical axons
guidance
Gli2
Slit1
Slit2
title_short Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
title_full Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
title_fullStr Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
title_full_unstemmed Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
title_sort Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
dc.creator.none.fl_str_mv Callejas-Marin, A
Moreno-Bravo, JA
Company, V
Madrigal, MP
Almagro-Garcia, F
Martinez, S
Puelles, E
author Callejas-Marin, A
author_facet Callejas-Marin, A
Moreno-Bravo, JA
Company, V
Madrigal, MP
Almagro-Garcia, F
Martinez, S
Puelles, E
author_role author
author2 Moreno-Bravo, JA
Company, V
Madrigal, MP
Almagro-Garcia, F
Martinez, S
Puelles, E
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv thalamocortical axons
guidance
Gli2
Slit1
Slit2
topic thalamocortical axons
guidance
Gli2
Slit1
Slit2
description The thalamocortical projections are part of the most important higher level processing connections in the vertebrates and follow a highly ordered pathway from their origin in the thalamus to the cerebral cortex. Their functional complexities are not only due to an extremely elaborate axon guidance process but also due to activity-dependent mechanisms. Gli2 is an intermediary transcription factor in the Sonic hedgehog (Shh) pathway. During neural early development, Shh has an important role in dorsoventral patterning, diencephalic anteroposterior patterning, and many later developmental processes, such as axon guidance and cell migration. Using a Gli2 knockout mouse line, we have studied the role of Shh signaling mediated by Gli2 in the development of the thalamocortical projections during embryonic development. In wild-type brains, we have described the normal trajectory of the thalamocortical axons into the context of the prosomeric model. Then, we have compared it with the altered thalamocortical axons course in Gli2 homozygous embryos. The thalamocortical axons followed different trajectories and were misdirected to other territories probably due to alterations in the Robo/Slit signaling mechanism. In conclusion, the alteration of Gli2-mediated Shh signaling produces an erroneous specification of several territories related with the thalamocortical axons. This is translated into a huge modification in the pathfinding signaling mechanisms needed for the correct wiring of the thalamocortical axons.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones8571
url https://isabial.portalinvestigacion.com/publicaciones8571
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Neuroanatomy
ISSN: 16625129
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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