Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and Virulence

https://portalciencia.ull.es/documentos/5e3c386429995246bbf5ece5

Bibliographic Details
Authors: González Carracedo, Mario Andrés, Brito, Nélida, Frías, Marcos, González, Celedonio
Format: article
Publication Date:2013
Country:España
Institution:Universidad de La Laguna (ULL)
Repository:RIULL. Repositorio Institucional de la Universidad de La Laguna
OAI Identifier:oai:riull.ull.es:915/41761
Online Access:http://riull.ull.es/xmlui/handle/915/41761
Access Level:Open access
Keyword:Protein O-glycosylation
Botrytis cinerea
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spelling Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and VirulenceGonzález Carracedo, Mario AndrésBrito, NélidaFrías, MarcosGonzález, CeledonioProtein O-glycosylationBotrytis cinereahttps://portalciencia.ull.es/documentos/5e3c386429995246bbf5ece5Protein O-glycosylation is crucial in determining the structure and function of numerous secreted and membrane-bound proteins. In fungi, this process begins with the addition of a mannose residue by protein O-mannosyltransferases (PMTs) in the lumen side of the ER membrane. We have generated mutants of the three Botrytis cinerea pmt genes to study their role in the virulence of this wide-range plant pathogen. B. cinerea PMTs, especially PMT2, are critical for the stability of the cell wall and are necessary for sporulation and for the generation of the extracellular matrix. PMTs are also individually required for full virulence in a variety of hosts, with a special role in the penetration of intact plant leaves. The most significant case is that of grapevine leaves, whose penetration requires the three functional PMTs. Furthermore, PMT2 also contributes significantly to fungal adherence on grapevine and tobacco leaves. Analysis of extracellular and membrane proteins showed significant changes in the pattern of protein secretion and glycosylation by the pmt mutants, and allowed the identification of new protein substrates putatively glycosylated by specific PMTs. Since plants do no possess these enzymes, PMTs constitute a promising target in the development of novel control strategies against B. cinerea.Bioquímica, Microbiología, Biología Celular y Genética202520252013info:eu-repo/semantics/articleapplication/pdfhttp://riull.ull.es/xmlui/handle/915/41761reponame:RIULL. Repositorio Institucional de la Universidad de La Lagunainstname:Universidad de La Laguna (ULL)InglésPLoS ONE June 2013, Volume 8, Issue 6, e65924Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ESoai:riull.ull.es:915/417612026-06-22T13:13:57Z
dc.title.none.fl_str_mv Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and Virulence
title Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and Virulence
spellingShingle Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and Virulence
González Carracedo, Mario Andrés
Protein O-glycosylation
Botrytis cinerea
title_short Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and Virulence
title_full Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and Virulence
title_fullStr Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and Virulence
title_full_unstemmed Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and Virulence
title_sort Botrytis cinerea Protein O-Mannosyltransferases Play Critical Roles in Morphogenesis, Growth, and Virulence
dc.creator.none.fl_str_mv González Carracedo, Mario Andrés
Brito, Nélida
Frías, Marcos
González, Celedonio
author González Carracedo, Mario Andrés
author_facet González Carracedo, Mario Andrés
Brito, Nélida
Frías, Marcos
González, Celedonio
author_role author
author2 Brito, Nélida
Frías, Marcos
González, Celedonio
author2_role author
author
author
dc.contributor.none.fl_str_mv Bioquímica, Microbiología, Biología Celular y Genética
dc.subject.none.fl_str_mv Protein O-glycosylation
Botrytis cinerea
topic Protein O-glycosylation
Botrytis cinerea
description https://portalciencia.ull.es/documentos/5e3c386429995246bbf5ece5
publishDate 2013
dc.date.none.fl_str_mv 2013
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://riull.ull.es/xmlui/handle/915/41761
url http://riull.ull.es/xmlui/handle/915/41761
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS ONE June 2013, Volume 8, Issue 6, e65924
dc.rights.none.fl_str_mv Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
rights_invalid_str_mv Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIULL. Repositorio Institucional de la Universidad de La Laguna
instname:Universidad de La Laguna (ULL)
instname_str Universidad de La Laguna (ULL)
reponame_str RIULL. Repositorio Institucional de la Universidad de La Laguna
collection RIULL. Repositorio Institucional de la Universidad de La Laguna
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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