Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats

We tested whether the administration procedure of quercetin affects its metabolite profile and antihypertensive activity. Spontaneously hypertensive rats (SHR) were randomly assigned to four experimental treatments: (1) 1 mL of 1% methylcellulose by oral gavage and 2% DMSO i.p. (control group); (2)...

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Autores: Galindo, P., González-Manzano, S., Zarzuelo, M. J., Gómez-Guzmán, M., Quintela, A. M., González-Paramás, A., Santos-Buelga, C., Pérez-Vizcaíno, F., Duarte, J., Jiménez, R.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/165844
Acceso en línea:http://hdl.handle.net/10366/165844
Access Level:acceso abierto
Palabra clave:Metabolite profile, Antihypertensive activity, Endothelial dysfunction, Vascular oxidative stress
3209 Farmacología
2411.03 Fisiología Cardiovascular
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spelling Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive ratsGalindo, P.González-Manzano, S.Zarzuelo, M. J.Gómez-Guzmán, M.Quintela, A. M.González-Paramás, A.Santos-Buelga, C.Pérez-Vizcaíno, F.Duarte, J.Jiménez, R.Metabolite profile, Antihypertensive activity, Endothelial dysfunction, Vascular oxidative stress3209 Farmacología2411.03 Fisiología CardiovascularWe tested whether the administration procedure of quercetin affects its metabolite profile and antihypertensive activity. Spontaneously hypertensive rats (SHR) were randomly assigned to four experimental treatments: (1) 1 mL of 1% methylcellulose by oral gavage and 2% DMSO i.p. (control group); (2) 10 mg kg-1 quercetin by oral gavage once daily and 2% DMSO i.p.; (3) 10 mg kg-1 quercetin by oral gavage divided in two daily doses (5 + 5 at 12 h intervals) and 2% DMSO i.p.; (4) 1 mL of 1% methylcellulose by oral gavage and 10 mg kg-1 quercetin i.p. injection. Rats were treated daily for 5 weeks. Single dose and two daily doses, in a long-term oral treatment were equally efficient, both restoring the impaired aortic endothelium-dependent vasodilatation and reducing mesenteric contractile response to phenylephrine, systolic blood pressure, heart rate, and heart and kidney hypertrophy. Attenuation of vascular NADPH oxidase-driven O2- production was also found in orally treated rats. Intraperitoneal administration reduced, to lesser extent than oral administration, the increased systolic blood pressure, being without effect to the endothelial dysfunction and vascular oxidative stress. In contrast, greater levels of metabolites were quantified following intraperitoneal compared to oral administration at any time point, except for higher plasma methylated quercetin aglycone in oral as compared to intraperitoneal administration at 2 but not at 8 h. In conclusion, oral quercetin was superior to intraperitoneal administration for the protection from cardiovascular complications in SHR. No differences were found between the oral administration as a single daily dose or divided into two daily doses.202520252012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/165844reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAGL2007-66108info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1658442026-06-07T06:28:51Z
dc.title.none.fl_str_mv Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
title Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
spellingShingle Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
Galindo, P.
Metabolite profile, Antihypertensive activity, Endothelial dysfunction, Vascular oxidative stress
3209 Farmacología
2411.03 Fisiología Cardiovascular
title_short Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
title_full Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
title_fullStr Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
title_full_unstemmed Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
title_sort Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
dc.creator.none.fl_str_mv Galindo, P.
González-Manzano, S.
Zarzuelo, M. J.
Gómez-Guzmán, M.
Quintela, A. M.
González-Paramás, A.
Santos-Buelga, C.
Pérez-Vizcaíno, F.
Duarte, J.
Jiménez, R.
author Galindo, P.
author_facet Galindo, P.
González-Manzano, S.
Zarzuelo, M. J.
Gómez-Guzmán, M.
Quintela, A. M.
González-Paramás, A.
Santos-Buelga, C.
Pérez-Vizcaíno, F.
Duarte, J.
Jiménez, R.
author_role author
author2 González-Manzano, S.
Zarzuelo, M. J.
Gómez-Guzmán, M.
Quintela, A. M.
González-Paramás, A.
Santos-Buelga, C.
Pérez-Vizcaíno, F.
Duarte, J.
Jiménez, R.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Metabolite profile, Antihypertensive activity, Endothelial dysfunction, Vascular oxidative stress
3209 Farmacología
2411.03 Fisiología Cardiovascular
topic Metabolite profile, Antihypertensive activity, Endothelial dysfunction, Vascular oxidative stress
3209 Farmacología
2411.03 Fisiología Cardiovascular
description We tested whether the administration procedure of quercetin affects its metabolite profile and antihypertensive activity. Spontaneously hypertensive rats (SHR) were randomly assigned to four experimental treatments: (1) 1 mL of 1% methylcellulose by oral gavage and 2% DMSO i.p. (control group); (2) 10 mg kg-1 quercetin by oral gavage once daily and 2% DMSO i.p.; (3) 10 mg kg-1 quercetin by oral gavage divided in two daily doses (5 + 5 at 12 h intervals) and 2% DMSO i.p.; (4) 1 mL of 1% methylcellulose by oral gavage and 10 mg kg-1 quercetin i.p. injection. Rats were treated daily for 5 weeks. Single dose and two daily doses, in a long-term oral treatment were equally efficient, both restoring the impaired aortic endothelium-dependent vasodilatation and reducing mesenteric contractile response to phenylephrine, systolic blood pressure, heart rate, and heart and kidney hypertrophy. Attenuation of vascular NADPH oxidase-driven O2- production was also found in orally treated rats. Intraperitoneal administration reduced, to lesser extent than oral administration, the increased systolic blood pressure, being without effect to the endothelial dysfunction and vascular oxidative stress. In contrast, greater levels of metabolites were quantified following intraperitoneal compared to oral administration at any time point, except for higher plasma methylated quercetin aglycone in oral as compared to intraperitoneal administration at 2 but not at 8 h. In conclusion, oral quercetin was superior to intraperitoneal administration for the protection from cardiovascular complications in SHR. No differences were found between the oral administration as a single daily dose or divided into two daily doses.
publishDate 2012
dc.date.none.fl_str_mv 2012
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/165844
url http://hdl.handle.net/10366/165844
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv AGL2007-66108
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
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