Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progression

This article belongs to the Special Issue Cell Methods: Molecular Events in the Progression of Human Tumor Cell Lines.

Detalhes bibliográficos
Autores: Pombero, Ana, García López, Raquel, Martínez, Salvador
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/353176
Acesso em linha:http://hdl.handle.net/10261/353176
Access Level:acceso abierto
Palavra-chave:Cell–cell contact
High-grade glial neoplasm
Filopodia
Glioblastoma
Pericytes
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spelling Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progressionPombero, AnaGarcía López, RaquelMartínez, SalvadorCell–cell contactHigh-grade glial neoplasmFilopodiaGlioblastomaPericytesThis article belongs to the Special Issue Cell Methods: Molecular Events in the Progression of Human Tumor Cell Lines.Multiple biological processes rely on direct intercellular interactions to regulate cell proliferation and migration in embryonic development and cancer processes. Tumor development and growth depends on close interactions between cancer cells and cells in the tumor microenvironment. During embryonic development, morphogenetic signals and direct cell contacts control cell proliferation, polarity, and morphogenesis. Cancer cells communicate with cells in the tumor niche through molecular signals and intercellular contacts, thereby modifying the vascular architecture and antitumor surveillance processes and consequently enabling tumor growth and survival. While looking for cell-to-cell signaling mechanisms that are common to both brain development and cancer progression, we have studied the infiltration process in glioblastoma multiforme (GBM), which is the most malignant primary brain tumor and with the worst prognosis. Cell-to-cell contacts, by means of filopodia-like structures, between GBM cells and brain pericytes (PCs) are necessary for adequate cell signaling during cancer infiltration; similarly, contacts between embryonic regions, via cytonemes, are required for embryo regionalization and development. This GBM–PC interaction provokes two important changes in the physiological function of these perivascular cells, namely, (i) vascular co-option with changes in cell contractility and vascular malformation, and (ii) changes in the PC transcriptome, modifying the microvesicles and protein secretome, which leads to the development of an immunosuppressive phenotype that promotes tumor immune tolerance. Moreover, the GTPase Cdc42 regulates cell polarity across organisms, from yeast to humans, playing a central role in GBM cell–PC interaction and maintaining vascular co-option. As such, a review of the molecular and cellular mechanisms underlying the development and maintenance of the physical interactions between cancer cells and PCs is of particular interest.This research was funded by MINECO/AEI/FEDER UE (grant number SAF2017-83702-R), ISCIII co-funded by ERDF/ESF (grant number RD16/001/0010), MCIN/AEI/10.13039/501100011033 (grant number PID2020-118171RB-100), the Valencian Regional Government (grant number PROMETEO CIPROM/2021/018), and by RICORS: Terapias avanzadas (TERAV) (grant number RD21/0017/0017).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Generalitat ValencianaEuropean CommissionAgencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)Instituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/353176reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83702-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118171RB-I00https://doi.org/10.3390/cells12091324Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3531762026-05-22T06:33:51Z
dc.title.none.fl_str_mv Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progression
title Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progression
spellingShingle Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progression
Pombero, Ana
Cell–cell contact
High-grade glial neoplasm
Filopodia
Glioblastoma
Pericytes
title_short Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progression
title_full Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progression
title_fullStr Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progression
title_full_unstemmed Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progression
title_sort Pericyte–glioblastoma cell interaction: A key target to prevent glioblastoma progression
dc.creator.none.fl_str_mv Pombero, Ana
García López, Raquel
Martínez, Salvador
author Pombero, Ana
author_facet Pombero, Ana
García López, Raquel
Martínez, Salvador
author_role author
author2 García López, Raquel
Martínez, Salvador
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Generalitat Valenciana
European Commission
Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cell–cell contact
High-grade glial neoplasm
Filopodia
Glioblastoma
Pericytes
topic Cell–cell contact
High-grade glial neoplasm
Filopodia
Glioblastoma
Pericytes
description This article belongs to the Special Issue Cell Methods: Molecular Events in the Progression of Human Tumor Cell Lines.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/353176
url http://hdl.handle.net/10261/353176
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83702-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118171RB-I00
https://doi.org/10.3390/cells12091324
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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