Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine

Studies designed to assess persistent postoperative pain (PPP) incidence after hepatectomies are lacking. Our aim was to assess PPP incidence 6 months after hepatectomies with intravenous (IV) or epidural (EPI) analgesia containing ketamine. Prospective observational comparative study between 2 coho...

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Autores: Masgoret, Paula, Gomar, Carmen, Tena, Beatriz|||0000-0001-9325-0858, Taurá, Pilar, Ríos, José|||0000-0002-0716-8784, Coca-Martinez, Miquel|||0000-0001-9180-2006
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253863
Acceso en línea:https://ddd.uab.cat/record/253863
https://dx.doi.org/urn:doi:10.1097/MD.0000000000006624
Access Level:acceso abierto
Palabra clave:Hepatectomy
Ketamine
Neuropathic pain
Persistent postoperative pain
Quantitative sensorial testing
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spelling Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamineMasgoret, PaulaGomar, CarmenTena, Beatriz|||0000-0001-9325-0858Taurá, PilarRíos, José|||0000-0002-0716-8784Coca-Martinez, Miquel|||0000-0001-9180-2006HepatectomyKetamineNeuropathic painPersistent postoperative painQuantitative sensorial testingStudies designed to assess persistent postoperative pain (PPP) incidence after hepatectomies are lacking. Our aim was to assess PPP incidence 6 months after hepatectomies with intravenous (IV) or epidural (EPI) analgesia containing ketamine. Prospective observational comparative study between 2 cohorts of patients submitted to hepatectomy. Patients received 1 of 2 analgesic regimes containing ketamine: EPI group or IV group. Visual analog scale (VAS), Neuropathic Pain Symptom Inventory (NPSI), Pain Catastrophizing Scale (PCS), and quantitative sensorial testing (QST: to determine area of hyperalgesia/allodynia) were assessed preoperatively and postoperatively at 2 h, 24 h, 7 days, 1 month, and 6 months. VAS ≥ 1 at 1 and 6 months was considered indicative of PPP and VAS > 3 was considered as not controlled pain. Side effects and complications were registered. Forty-four patients were included: 23 in EPI group and 21 in IV group. Patients in IV group were older and had more comorbidities. No patient presented VAS > 3 at 1 or 6 months. VAS ≥ 1 at 1 and 6 months was 36.4% and 22.7%, respectively. No differences in VAS, NPSI, or PCS were found between groups. Allodynia/hyperalgesia area did not differ between groups and was infrequent and slight. Pain pressure threshold in the wound vertical component was significantly higher in EPI group after 7 days. IV group showed more cognitive side effects. Incidence of PPP at 6 months after open hepatectomies with EPI or IV analgesia containing ketamine was lower than previously reported for other abdominal surgeries. Ketamine influence on low PPP incidence and hyperalgesia cannot be discarded. 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253863https://dx.doi.org/urn:doi:10.1097/MD.0000000000006624reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució i la comunicació pública de l'obra, sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2538632026-06-06T12:50:31Z
dc.title.none.fl_str_mv Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine
title Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine
spellingShingle Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine
Masgoret, Paula
Hepatectomy
Ketamine
Neuropathic pain
Persistent postoperative pain
Quantitative sensorial testing
title_short Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine
title_full Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine
title_fullStr Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine
title_full_unstemmed Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine
title_sort Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine
dc.creator.none.fl_str_mv Masgoret, Paula
Gomar, Carmen
Tena, Beatriz|||0000-0001-9325-0858
Taurá, Pilar
Ríos, José|||0000-0002-0716-8784
Coca-Martinez, Miquel|||0000-0001-9180-2006
author Masgoret, Paula
author_facet Masgoret, Paula
Gomar, Carmen
Tena, Beatriz|||0000-0001-9325-0858
Taurá, Pilar
Ríos, José|||0000-0002-0716-8784
Coca-Martinez, Miquel|||0000-0001-9180-2006
author_role author
author2 Gomar, Carmen
Tena, Beatriz|||0000-0001-9325-0858
Taurá, Pilar
Ríos, José|||0000-0002-0716-8784
Coca-Martinez, Miquel|||0000-0001-9180-2006
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hepatectomy
Ketamine
Neuropathic pain
Persistent postoperative pain
Quantitative sensorial testing
topic Hepatectomy
Ketamine
Neuropathic pain
Persistent postoperative pain
Quantitative sensorial testing
description Studies designed to assess persistent postoperative pain (PPP) incidence after hepatectomies are lacking. Our aim was to assess PPP incidence 6 months after hepatectomies with intravenous (IV) or epidural (EPI) analgesia containing ketamine. Prospective observational comparative study between 2 cohorts of patients submitted to hepatectomy. Patients received 1 of 2 analgesic regimes containing ketamine: EPI group or IV group. Visual analog scale (VAS), Neuropathic Pain Symptom Inventory (NPSI), Pain Catastrophizing Scale (PCS), and quantitative sensorial testing (QST: to determine area of hyperalgesia/allodynia) were assessed preoperatively and postoperatively at 2 h, 24 h, 7 days, 1 month, and 6 months. VAS ≥ 1 at 1 and 6 months was considered indicative of PPP and VAS > 3 was considered as not controlled pain. Side effects and complications were registered. Forty-four patients were included: 23 in EPI group and 21 in IV group. Patients in IV group were older and had more comorbidities. No patient presented VAS > 3 at 1 or 6 months. VAS ≥ 1 at 1 and 6 months was 36.4% and 22.7%, respectively. No differences in VAS, NPSI, or PCS were found between groups. Allodynia/hyperalgesia area did not differ between groups and was infrequent and slight. Pain pressure threshold in the wound vertical component was significantly higher in EPI group after 7 days. IV group showed more cognitive side effects. Incidence of PPP at 6 months after open hepatectomies with EPI or IV analgesia containing ketamine was lower than previously reported for other abdominal surgeries. Ketamine influence on low PPP incidence and hyperalgesia cannot be discarded.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253863
https://dx.doi.org/urn:doi:10.1097/MD.0000000000006624
url https://ddd.uab.cat/record/253863
https://dx.doi.org/urn:doi:10.1097/MD.0000000000006624
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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