Gut epithelial barrier markers in patients with obstructive sleep apnea
Background: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic sy...
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/20314 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/20314 |
| Access Level: | acceso abierto |
| Palabra clave: | Zonulin Fatty acid binding protein (I-FABP) Intestinal wall Sleep apnea Biomarcadores Síndrome Metabólico Femenino Enfermedad del Hígado Graso no Alcohólico Masculino Circunferencia de la Cintura Toxina del Cólera Apnea Obstructiva del Sueño Humanos Persona de Mediana Edad Obesidad Alanina Transaminasa Mucosa Intestinal Proteínas de Unión a ácidos Grasos Estudios Retrospectivos Adulto Absorción Intestinal Estudios de Casos y Controles Metabolic Syndrome Case-Control Studies Adult Intestinal Absorption Sleep Apnea, Obstructive Cholera Toxin Humans Alanine Transaminase Intestinal Mucosa Middle Aged Non-alcoholic Fatty Liver Disease Obesity Male Biomarkers Female Fatty Acid-Binding Proteins Waist Circumference Retrospective Studies |
| Sumario: | Background: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: The results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA. |
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