Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes

Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies in...

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Autores: Ribasés Haro, Marta, Mitjans Niubó, Marina, Hartman, C.A., Soler Artigas, María, Demontis, D., Larsson, H., Ramos-Quiroga, Josep Antoni, Kuntsi, J., Faraone, S.V., Børglum, A.D., Reif, A., Franke, B., Cormand Rifà, Bru
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/209907
Acesso em linha:https://hdl.handle.net/2445/209907
Access Level:acceso abierto
Palavra-chave:Trastorns per dèficit d'atenció amb hiperactivitat en els adults
Trastorns per dèficit d'atenció amb hiperactivitat en els infants
Genètica
Attention deficit disorder with hyperactivity in adults
Attention deficit disorder with hyperactivity in children
Genetics
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spelling Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related PhenotypesRibasés Haro, MartaMitjans Niubó, MarinaHartman, C.A.Soler Artigas, MaríaDemontis, D.Larsson, H.Ramos-Quiroga, Josep AntoniKuntsi, J.Faraone, S.V.Børglum, A.D.Reif, A.Franke, B.Cormand Rifà, BruTrastorns per dèficit d'atenció amb hiperactivitat en els adultsTrastorns per dèficit d'atenció amb hiperactivitat en els infantsGenèticaAttention deficit disorder with hyperactivity in adultsAttention deficit disorder with hyperactivity in childrenGeneticsAttention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.Elsevier2024202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion20 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/209907Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.neubiorev.2023.105313Neuroscience and Biobehavioral Reviews, 2023, vol. 153, p. 1-20https://doi.org/10.1016/j.neubiorev.2023.105313cc-by-nc-nd (c) Ribasés Haro, Marta et al., 2023http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2099072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
title Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
spellingShingle Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
Ribasés Haro, Marta
Trastorns per dèficit d'atenció amb hiperactivitat en els adults
Trastorns per dèficit d'atenció amb hiperactivitat en els infants
Genètica
Attention deficit disorder with hyperactivity in adults
Attention deficit disorder with hyperactivity in children
Genetics
title_short Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
title_full Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
title_fullStr Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
title_full_unstemmed Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
title_sort Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
dc.creator.none.fl_str_mv Ribasés Haro, Marta
Mitjans Niubó, Marina
Hartman, C.A.
Soler Artigas, María
Demontis, D.
Larsson, H.
Ramos-Quiroga, Josep Antoni
Kuntsi, J.
Faraone, S.V.
Børglum, A.D.
Reif, A.
Franke, B.
Cormand Rifà, Bru
author Ribasés Haro, Marta
author_facet Ribasés Haro, Marta
Mitjans Niubó, Marina
Hartman, C.A.
Soler Artigas, María
Demontis, D.
Larsson, H.
Ramos-Quiroga, Josep Antoni
Kuntsi, J.
Faraone, S.V.
Børglum, A.D.
Reif, A.
Franke, B.
Cormand Rifà, Bru
author_role author
author2 Mitjans Niubó, Marina
Hartman, C.A.
Soler Artigas, María
Demontis, D.
Larsson, H.
Ramos-Quiroga, Josep Antoni
Kuntsi, J.
Faraone, S.V.
Børglum, A.D.
Reif, A.
Franke, B.
Cormand Rifà, Bru
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trastorns per dèficit d'atenció amb hiperactivitat en els adults
Trastorns per dèficit d'atenció amb hiperactivitat en els infants
Genètica
Attention deficit disorder with hyperactivity in adults
Attention deficit disorder with hyperactivity in children
Genetics
topic Trastorns per dèficit d'atenció amb hiperactivitat en els adults
Trastorns per dèficit d'atenció amb hiperactivitat en els infants
Genètica
Attention deficit disorder with hyperactivity in adults
Attention deficit disorder with hyperactivity in children
Genetics
description Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/209907
url https://hdl.handle.net/2445/209907
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.neubiorev.2023.105313
Neuroscience and Biobehavioral Reviews, 2023, vol. 153, p. 1-20
https://doi.org/10.1016/j.neubiorev.2023.105313
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Ribasés Haro, Marta et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Ribasés Haro, Marta et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 20 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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