Smoking history and breast cancer risk by pathological subtype: MCC-Spain study

Peñalver Argüeso, Belén; García Esquinas, Esther; Castelló, Adela; Fernández de Larrea Baz, Nerea; Castaño Vinyals, Gemma; Amiano, Pilar; Fernández Villa, Tania; Guevara, Marcela; Fernández Tardón, Guillermo; Alguacil, Juan; Obón Santacana, Mireia; Gómez Acebo, Inés; Pinto Carbó, Marina; Marcos Gragera, Rafael; Aragonés, Nuria; Aizpurua, Amaia; Martín Sánchez, Vicente; Ardanaz, Eva; Dierssen Sotos, Trinidad; Jiménez Moleón, Jose Juan; Kogevinas, Manolis; Pollán, Marina; Pérez Gómez, Beatriz

Smoking history and breast cancer risk by pathological subtype: MCC-Spain study

INTRODUCTION The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action.METHODS In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903...

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Authors:	Peñalver Argüeso, Belén, García Esquinas, Esther, Castelló, Adela, Fernández de Larrea Baz, Nerea, Castaño Vinyals, Gemma, Amiano, Pilar, Fernández Villa, Tania, Guevara, Marcela, Fernández Tardón, Guillermo, Alguacil, Juan, Obón Santacana, Mireia, Gómez Acebo, Inés, Pinto Carbó, Marina, Marcos Gragera, Rafael, Aragonés, Nuria, Aizpurua, Amaia, Martín Sánchez, Vicente, Ardanaz, Eva, Dierssen Sotos, Trinidad, Jiménez Moleón, Jose Juan, Kogevinas, Manolis, Pollán, Marina, Pérez Gómez, Beatriz
Format:	article
Status:	Published version
Publication Date:	2023
Country:	España
Institution:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/205382
Online Access:	https://hdl.handle.net/2445/205382
Access Level:	Open access
Keyword:	Hàbit de fumar Càncer de mama Smoking Breast cancer

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spelling	Smoking history and breast cancer risk by pathological subtype: MCC-Spain studyPeñalver Argüeso, BelénGarcía Esquinas, EstherCastelló, AdelaFernández de Larrea Baz, NereaCastaño Vinyals, GemmaAmiano, PilarFernández Villa, TaniaGuevara, MarcelaFernández Tardón, GuillermoAlguacil, JuanObón Santacana, MireiaGómez Acebo, InésPinto Carbó, MarinaMarcos Gragera, RafaelAragonés, NuriaAizpurua, AmaiaMartín Sánchez, VicenteArdanaz, EvaDierssen Sotos, TrinidadJiménez Moleón, Jose JuanKogevinas, ManolisPollán, MarinaPérez Gómez, BeatrizHàbit de fumarCàncer de mamaSmokingBreast cancerINTRODUCTION The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action.METHODS In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models.RESULTS Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked >= 30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking >= 10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11-0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47-0.98) or 10-25 pack-years (AOR=0.62; 95% CI: 0.42-0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk.CONCLUSIONS Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.E.U. European Publishing2024202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfhttps://hdl.handle.net/2445/205382Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.18332/tid/174132Tobacco Induced Diseases, 2023, vol. 21, issue. 11, p. 1-16https://doi.org/10.18332/tid/174132cc by (c) Peñalver Argüeso, Belén et al, 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2053822026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title	Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
spellingShingle	Smoking history and breast cancer risk by pathological subtype: MCC-Spain study Peñalver Argüeso, Belén Hàbit de fumar Càncer de mama Smoking Breast cancer
title_short	Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_full	Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_fullStr	Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_full_unstemmed	Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_sort	Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
dc.creator.none.fl_str_mv	Peñalver Argüeso, Belén García Esquinas, Esther Castelló, Adela Fernández de Larrea Baz, Nerea Castaño Vinyals, Gemma Amiano, Pilar Fernández Villa, Tania Guevara, Marcela Fernández Tardón, Guillermo Alguacil, Juan Obón Santacana, Mireia Gómez Acebo, Inés Pinto Carbó, Marina Marcos Gragera, Rafael Aragonés, Nuria Aizpurua, Amaia Martín Sánchez, Vicente Ardanaz, Eva Dierssen Sotos, Trinidad Jiménez Moleón, Jose Juan Kogevinas, Manolis Pollán, Marina Pérez Gómez, Beatriz
author	Peñalver Argüeso, Belén
author_facet	Peñalver Argüeso, Belén García Esquinas, Esther Castelló, Adela Fernández de Larrea Baz, Nerea Castaño Vinyals, Gemma Amiano, Pilar Fernández Villa, Tania Guevara, Marcela Fernández Tardón, Guillermo Alguacil, Juan Obón Santacana, Mireia Gómez Acebo, Inés Pinto Carbó, Marina Marcos Gragera, Rafael Aragonés, Nuria Aizpurua, Amaia Martín Sánchez, Vicente Ardanaz, Eva Dierssen Sotos, Trinidad Jiménez Moleón, Jose Juan Kogevinas, Manolis Pollán, Marina Pérez Gómez, Beatriz
author_role	author
author2	García Esquinas, Esther Castelló, Adela Fernández de Larrea Baz, Nerea Castaño Vinyals, Gemma Amiano, Pilar Fernández Villa, Tania Guevara, Marcela Fernández Tardón, Guillermo Alguacil, Juan Obón Santacana, Mireia Gómez Acebo, Inés Pinto Carbó, Marina Marcos Gragera, Rafael Aragonés, Nuria Aizpurua, Amaia Martín Sánchez, Vicente Ardanaz, Eva Dierssen Sotos, Trinidad Jiménez Moleón, Jose Juan Kogevinas, Manolis Pollán, Marina Pérez Gómez, Beatriz
author2_role	author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Hàbit de fumar Càncer de mama Smoking Breast cancer
topic	Hàbit de fumar Càncer de mama Smoking Breast cancer
description	INTRODUCTION The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action.METHODS In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models.RESULTS Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked >= 30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking >= 10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11-0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47-0.98) or 10-25 pack-years (AOR=0.62; 95% CI: 0.42-0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk.CONCLUSIONS Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.
publishDate	2023
dc.date.none.fl_str_mv	2023 2024 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/205382
url	https://hdl.handle.net/2445/205382
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.18332/tid/174132 Tobacco Induced Diseases, 2023, vol. 21, issue. 11, p. 1-16 https://doi.org/10.18332/tid/174132
dc.rights.none.fl_str_mv	cc by (c) Peñalver Argüeso, Belén et al, 2023 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by (c) Peñalver Argüeso, Belén et al, 2023 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	16 p. application/pdf
dc.publisher.none.fl_str_mv	E.U. European Publishing
publisher.none.fl_str_mv	E.U. European Publishing
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Smoking history and breast cancer risk by pathological subtype: MCC-Spain study

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