The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis

Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistan...

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Autores: van Gils, Veerle, Rizzo, Marianna, Côté, Jade, Viechtbauer, Wofgang, Fanelli, Giuseppe, Salas Salvadó, Jordi, Wimberley, Theresa, Bulló, Mònica, Fernández Aranda, Fernando, Dalsgaard, Søren, Visser, Pieter Jelle, Jansen, Willemijn J., Vos, Stephanie J.B.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/214252
Acesso em linha:https://hdl.handle.net/2445/214252
Access Level:acceso abierto
Palavra-chave:Malaltia d'Alzheimer
Glucosa
Diabetis
Marcadors bioquímics
Alzheimer's disease
Glucose
Diabetes
Biochemical markers
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spelling The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysisvan Gils, VeerleRizzo, MariannaCôté, JadeViechtbauer, WofgangFanelli, GiuseppeSalas Salvadó, JordiWimberley, TheresaBulló, MònicaFernández Aranda, FernandoDalsgaard, SørenVisser, Pieter JelleJansen, Willemijn J.Vos, Stephanie J.B.Malaltia d'AlzheimerGlucosaDiabetisMarcadors bioquímicsAlzheimer's diseaseGlucoseDiabetesBiochemical markersConflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-β and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0.11[0.03-0.18], p=0.008; I2=68%), but were not associated with amyloid-β biomarkers (r=-0.06[-0.13-0.01], p=0.08; I2=81%). Meta-regression revealed that glucose metabolism and DM were specifically associated with tau biomarkers in population settings (p=0.001). Furthermore, more impaired glucose metabolism and DM status were associated with lower amyloid-β biomarkers in memory clinic settings (p=0.004), and in studies with a higher prevalence of dementia (p<0.001) or lower cognitive scores (p=0.04). These findings indicate that DM is associated with biomarkers of tau but not with amyloid-β. This knowledge is valuable for improving dementia and DM diagnostics and treatment.Elsevier2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/214252Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.neubiorev.2024.105604Neuroscience and Biobehavioral Reviews, 2024, vol. 159https://doi.org/10.1016/j.neubiorev.2024.105604cc-by (c) van Gils, Veerle et al., 2024https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2142522026-05-29T05:05:01Z
dc.title.none.fl_str_mv The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis
title The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis
spellingShingle The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis
van Gils, Veerle
Malaltia d'Alzheimer
Glucosa
Diabetis
Marcadors bioquímics
Alzheimer's disease
Glucose
Diabetes
Biochemical markers
title_short The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis
title_full The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis
title_fullStr The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis
title_full_unstemmed The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis
title_sort The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis
dc.creator.none.fl_str_mv van Gils, Veerle
Rizzo, Marianna
Côté, Jade
Viechtbauer, Wofgang
Fanelli, Giuseppe
Salas Salvadó, Jordi
Wimberley, Theresa
Bulló, Mònica
Fernández Aranda, Fernando
Dalsgaard, Søren
Visser, Pieter Jelle
Jansen, Willemijn J.
Vos, Stephanie J.B.
author van Gils, Veerle
author_facet van Gils, Veerle
Rizzo, Marianna
Côté, Jade
Viechtbauer, Wofgang
Fanelli, Giuseppe
Salas Salvadó, Jordi
Wimberley, Theresa
Bulló, Mònica
Fernández Aranda, Fernando
Dalsgaard, Søren
Visser, Pieter Jelle
Jansen, Willemijn J.
Vos, Stephanie J.B.
author_role author
author2 Rizzo, Marianna
Côté, Jade
Viechtbauer, Wofgang
Fanelli, Giuseppe
Salas Salvadó, Jordi
Wimberley, Theresa
Bulló, Mònica
Fernández Aranda, Fernando
Dalsgaard, Søren
Visser, Pieter Jelle
Jansen, Willemijn J.
Vos, Stephanie J.B.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Glucosa
Diabetis
Marcadors bioquímics
Alzheimer's disease
Glucose
Diabetes
Biochemical markers
topic Malaltia d'Alzheimer
Glucosa
Diabetis
Marcadors bioquímics
Alzheimer's disease
Glucose
Diabetes
Biochemical markers
description Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-β and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0.11[0.03-0.18], p=0.008; I2=68%), but were not associated with amyloid-β biomarkers (r=-0.06[-0.13-0.01], p=0.08; I2=81%). Meta-regression revealed that glucose metabolism and DM were specifically associated with tau biomarkers in population settings (p=0.001). Furthermore, more impaired glucose metabolism and DM status were associated with lower amyloid-β biomarkers in memory clinic settings (p=0.004), and in studies with a higher prevalence of dementia (p<0.001) or lower cognitive scores (p=0.04). These findings indicate that DM is associated with biomarkers of tau but not with amyloid-β. This knowledge is valuable for improving dementia and DM diagnostics and treatment.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214252
url https://hdl.handle.net/2445/214252
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.neubiorev.2024.105604
Neuroscience and Biobehavioral Reviews, 2024, vol. 159
https://doi.org/10.1016/j.neubiorev.2024.105604
dc.rights.none.fl_str_mv cc-by (c) van Gils, Veerle et al., 2024
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) van Gils, Veerle et al., 2024
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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