Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles

Understanding how molecular features dictate the self-assembly of amphiphilic block copolymers into well-defined nanostructures is essential for the rational design of advanced soft materials. However, the large number of interdependent parameters involved, such as particle size, aggregation number,...

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Detalhes bibliográficos
Autores: Muñoz-López, José, Tuveri, Gian Marco, Barbieri, Valentino, Basile, Marco, Cosenza, V., Lorenz, Christian D., Ruiz-Perez, Lorena, Battaglia, Giuseppe
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2026
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/228329
Acesso em linha:https://hdl.handle.net/2445/228329
Access Level:Acceso aberto
Palavra-chave:Biopolímers
Polímers
Biopolymers
Polymers
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spelling Decoding the Conformation of Polylactic Acid in Block Copolymer MicellesMuñoz-López, JoséTuveri, Gian MarcoBarbieri, ValentinoBasile, MarcoCosenza, V.Lorenz, Christian D.Ruiz-Perez, LorenaBattaglia, GiuseppeBiopolímersPolímersBiopolymersPolymersUnderstanding how molecular features dictate the self-assembly of amphiphilic block copolymers into well-defined nanostructures is essential for the rational design of advanced soft materials. However, the large number of interdependent parameters involved, such as particle size, aggregation number, interfacial curvature, and molecular weight, makes it challenging to establish general design principles. Here we establish a scaling-based framework for PEG-b-PLA micelles with a fixed hydrophilic−hydrophobic ratio. Systematic variation of molecular weights enables precise control of micelle size and aggregation number, quantified by DLS, cryo-TEM, and MALS.American Chemical Society2026202620262026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5 p.application/pdfhttps://hdl.handle.net/2445/228329Articles publicats en revistes (Física Aplicada)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1021/jacs.5c19227JACS Au, 2026, vol. 148, p. A-Ehttps://doi.org/10.1021/jacs.5c19227cc-by (c) J. Muñoz-López et al., 2026http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2283292026-05-29T05:05:01Z
dc.title.none.fl_str_mv Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
title Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
spellingShingle Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
Muñoz-López, José
Biopolímers
Polímers
Biopolymers
Polymers
title_short Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
title_full Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
title_fullStr Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
title_full_unstemmed Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
title_sort Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
dc.creator.none.fl_str_mv Muñoz-López, José
Tuveri, Gian Marco
Barbieri, Valentino
Basile, Marco
Cosenza, V.
Lorenz, Christian D.
Ruiz-Perez, Lorena
Battaglia, Giuseppe
author Muñoz-López, José
author_facet Muñoz-López, José
Tuveri, Gian Marco
Barbieri, Valentino
Basile, Marco
Cosenza, V.
Lorenz, Christian D.
Ruiz-Perez, Lorena
Battaglia, Giuseppe
author_role author
author2 Tuveri, Gian Marco
Barbieri, Valentino
Basile, Marco
Cosenza, V.
Lorenz, Christian D.
Ruiz-Perez, Lorena
Battaglia, Giuseppe
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biopolímers
Polímers
Biopolymers
Polymers
topic Biopolímers
Polímers
Biopolymers
Polymers
description Understanding how molecular features dictate the self-assembly of amphiphilic block copolymers into well-defined nanostructures is essential for the rational design of advanced soft materials. However, the large number of interdependent parameters involved, such as particle size, aggregation number, interfacial curvature, and molecular weight, makes it challenging to establish general design principles. Here we establish a scaling-based framework for PEG-b-PLA micelles with a fixed hydrophilic−hydrophobic ratio. Systematic variation of molecular weights enables precise control of micelle size and aggregation number, quantified by DLS, cryo-TEM, and MALS.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/228329
url https://hdl.handle.net/2445/228329
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1021/jacs.5c19227
JACS Au, 2026, vol. 148, p. A-E
https://doi.org/10.1021/jacs.5c19227
dc.rights.none.fl_str_mv cc-by (c) J. Muñoz-López et al., 2026
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) J. Muñoz-López et al., 2026
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5 p.
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Física Aplicada)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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