Stereoselective oxidation of titanium(IV) enolates with oxygen

A novel approach to synthesize enantiomerically pure α-hydroxy carboxylic derivatives is reported. A highly stereoselective oxidation of titanium(IV) enolates from chiral N-acyloxazolidinones is performed with oxygen under simple experimental conditions that do not require any reducing steps. The su...

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Detalles Bibliográficos
Autores: Gómez Palomino, Alejandro, Romea, Pedro, Urpí Tubella, Fèlix
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/128156
Acceso en línea:https://hdl.handle.net/2445/128156
Access Level:acceso abierto
Palabra clave:Titani
Estereoquímica
Quiralitat
Titanium
Stereochemistry
Chirality
Descripción
Sumario:A novel approach to synthesize enantiomerically pure α-hydroxy carboxylic derivatives is reported. A highly stereoselective oxidation of titanium(IV) enolates from chiral N-acyloxazolidinones is performed with oxygen under simple experimental conditions that do not require any reducing steps. The success of this approach depends on the biradical character of titanium(IV) enolates.