Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study

Background: Cardiac amyloidosis (CA) could be a common cause of heart failure (HF). The objective of the study was to estimate the prevalence of CA in patients with HF. Methods: Observational, prospective, and multicenter study involving 30 Spanish hospitals. A total of 453 patients ≥ 65 years with...

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Autores: Ruiz-Hueso, Rocío, Salamanca-Bautista, Prado, Quesada-Simón, Maria Angustias, Yun, Sergi, Conde-Martel, Alicia, Morales Rull, José Luis, Suárez-Gil, Roi, García-García, José Ángel, Llàcer, Pau, Fonseca-Aizpuru, Eva María, Amores-Arriaga, Beatriz, Martínez-González, Ángel, Armengou-Arxe, Arola, Peña-Somovilla, José Luis, López-Reboiro, Manuel Lorenzo, Aramburu-Bodas, Óscar, PREVAMIC Investigators Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/464341
Acceso en línea:https://doi.org/10.3390/jcm12062273
https://hdl.handle.net/10459.1/464341
Access Level:acceso abierto
Palabra clave:Cardiac amyloidosis
Epidemiology
Heart failure
Prevalence
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spelling Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC StudyRuiz-Hueso, RocíoSalamanca-Bautista, PradoQuesada-Simón, Maria AngustiasYun, SergiConde-Martel, AliciaMorales Rull, José LuisSuárez-Gil, RoiGarcía-García, José ÁngelLlàcer, PauFonseca-Aizpuru, Eva MaríaAmores-Arriaga, BeatrizMartínez-González, ÁngelArmengou-Arxe, ArolaPeña-Somovilla, José LuisLópez-Reboiro, Manuel LorenzoAramburu-Bodas, ÓscarPREVAMIC Investigators GroupCardiac amyloidosisEpidemiologyHeart failurePrevalenceBackground: Cardiac amyloidosis (CA) could be a common cause of heart failure (HF). The objective of the study was to estimate the prevalence of CA in patients with HF. Methods: Observational, prospective, and multicenter study involving 30 Spanish hospitals. A total of 453 patients ≥ 65 years with HF and an interventricular septum or posterior wall thickness > 12 mm were included. All patients underwent a 99mTc-DPD/PYP/HMDP scintigraphy and monoclonal bands were studied, following the current criteria for non-invasive diagnosis. In inconclusive cases, biopsies were performed. Results: The vast majority of CA were diagnosed non-invasively. The prevalence was 20.1%. Most of the CA were transthyretin (ATTR-CM, 84.6%), with a minority of cardiac light-chain amyloidosis (AL-CM, 2.2%). The remaining (13.2%) was untyped. The prevalence was significantly higher in men (60.1% vs 39.9%, p = 0.019). Of the patients with CA, 26.5% had a left ventricular ejection fraction less than 50%. Conclusions: CA was the cause of HF in one out of five patients and should be screened in the elderly with HF and myocardial thickening, regardless of sex and LVEF. Few transthyretin-gene-sequencing studies were performed in older patients. In many patients, it was not possible to determine the amyloid subtype.This research is sponsored by the Heart Failure and Atrial Fibrillation Working Group of the Spanish Society of Internal Medicine and is funded through the Pfizer Independent Research Grants Program (grant number 545277739)MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/jcm12062273https://hdl.handle.net/10459.1/464341reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.3390/jcm12062273Journal of Clinical Medicine, 2023, vol. 12, núm. 6, 2273cc-by (c) Rocío Ruiz-Hueso et al., 2023Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/4643412026-05-29T05:05:01Z
dc.title.none.fl_str_mv Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
spellingShingle Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
Ruiz-Hueso, Rocío
Cardiac amyloidosis
Epidemiology
Heart failure
Prevalence
title_short Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title_full Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title_fullStr Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title_full_unstemmed Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title_sort Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
dc.creator.none.fl_str_mv Ruiz-Hueso, Rocío
Salamanca-Bautista, Prado
Quesada-Simón, Maria Angustias
Yun, Sergi
Conde-Martel, Alicia
Morales Rull, José Luis
Suárez-Gil, Roi
García-García, José Ángel
Llàcer, Pau
Fonseca-Aizpuru, Eva María
Amores-Arriaga, Beatriz
Martínez-González, Ángel
Armengou-Arxe, Arola
Peña-Somovilla, José Luis
López-Reboiro, Manuel Lorenzo
Aramburu-Bodas, Óscar
PREVAMIC Investigators Group
author Ruiz-Hueso, Rocío
author_facet Ruiz-Hueso, Rocío
Salamanca-Bautista, Prado
Quesada-Simón, Maria Angustias
Yun, Sergi
Conde-Martel, Alicia
Morales Rull, José Luis
Suárez-Gil, Roi
García-García, José Ángel
Llàcer, Pau
Fonseca-Aizpuru, Eva María
Amores-Arriaga, Beatriz
Martínez-González, Ángel
Armengou-Arxe, Arola
Peña-Somovilla, José Luis
López-Reboiro, Manuel Lorenzo
Aramburu-Bodas, Óscar
PREVAMIC Investigators Group
author_role author
author2 Salamanca-Bautista, Prado
Quesada-Simón, Maria Angustias
Yun, Sergi
Conde-Martel, Alicia
Morales Rull, José Luis
Suárez-Gil, Roi
García-García, José Ángel
Llàcer, Pau
Fonseca-Aizpuru, Eva María
Amores-Arriaga, Beatriz
Martínez-González, Ángel
Armengou-Arxe, Arola
Peña-Somovilla, José Luis
López-Reboiro, Manuel Lorenzo
Aramburu-Bodas, Óscar
PREVAMIC Investigators Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cardiac amyloidosis
Epidemiology
Heart failure
Prevalence
topic Cardiac amyloidosis
Epidemiology
Heart failure
Prevalence
description Background: Cardiac amyloidosis (CA) could be a common cause of heart failure (HF). The objective of the study was to estimate the prevalence of CA in patients with HF. Methods: Observational, prospective, and multicenter study involving 30 Spanish hospitals. A total of 453 patients ≥ 65 years with HF and an interventricular septum or posterior wall thickness > 12 mm were included. All patients underwent a 99mTc-DPD/PYP/HMDP scintigraphy and monoclonal bands were studied, following the current criteria for non-invasive diagnosis. In inconclusive cases, biopsies were performed. Results: The vast majority of CA were diagnosed non-invasively. The prevalence was 20.1%. Most of the CA were transthyretin (ATTR-CM, 84.6%), with a minority of cardiac light-chain amyloidosis (AL-CM, 2.2%). The remaining (13.2%) was untyped. The prevalence was significantly higher in men (60.1% vs 39.9%, p = 0.019). Of the patients with CA, 26.5% had a left ventricular ejection fraction less than 50%. Conclusions: CA was the cause of HF in one out of five patients and should be screened in the elderly with HF and myocardial thickening, regardless of sex and LVEF. Few transthyretin-gene-sequencing studies were performed in older patients. In many patients, it was not possible to determine the amyloid subtype.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm12062273
https://hdl.handle.net/10459.1/464341
url https://doi.org/10.3390/jcm12062273
https://hdl.handle.net/10459.1/464341
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/jcm12062273
Journal of Clinical Medicine, 2023, vol. 12, núm. 6, 2273
dc.rights.none.fl_str_mv cc-by (c) Rocío Ruiz-Hueso et al., 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Rocío Ruiz-Hueso et al., 2023
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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